Ascorbic Acid 2-Phosphate Releasing Supercritically Foamed Porous Poly-L-Lactide-Co- ε-Caprolactone Scaffold Enhances the Collagen Production of Human Vaginal Stromal Cells: A New Approach for Vaginal Tissue Engineering
Conclusion:This is the first study evaluating the effect of A2P on vaginal tissue engineering, and the results are highly encouraging, indicating that scPLCLA2P has potential as a scaffold for vaginal tissue engineering.Graphical Abstract (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 31, 2023 Category: Biotechnology Source Type: research

Define of Optimal Addition Period of Osteogenic Peptide to Accelerate the Osteogenic Differentiation of Human Pluripotent Stem Cells
Conclusion:The differentiation efficiency of cells could be improved by determining the optimal treatment period. Our study has great value in maximizing the differentiation of hPSCs by adding osteogenesis peptides based on the revealed mechanisms and promoting the application of hPSCs in bone tissue regeneration. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 30, 2023 Category: Biotechnology Source Type: research

Photobiomodulation Facilitates Rat Cutaneous Wound Healing by Promoting Epidermal Stem Cells and Hair Follicle Stem Cells Proliferation
Conclusion:PBM accelerates wound healing by enhancing reepithelialization through promoting ESCs and HFSCs proliferation and elevating the expression of genes associated with stem cells and cell adhesion. This may provide a valuable alternative strategy to promote wound healing and reepithelialization by modulating the proliferation of  skin derived stem cells and regulating genes related to cell adhesion. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 26, 2023 Category: Biotechnology Source Type: research

Three Dimensional Bioprinting for Hepatic Tissue Engineering: From In Vitro Models to Clinical Applications
AbstractFabrication of functional organs is the holy grail of tissue engineering and the possibilities of repairing a partial or complete liver to treat chronic liver disorders are discussed in this review. Liver is the largest gland in the human body and plays a responsible role in majority of metabolic function and processes. Chronic liver disease is one of the leading causes of death globally and the current treatment strategy of organ transplantation holds its own demerits. Hence there is a need to develop anin vitro liver model that mimics the native microenvironment. The developed model should be a reliable to unders...
Source: Tissue Engineering and Regenerative Medicine - October 26, 2023 Category: Biotechnology Source Type: research

PVA/PVP Nanofibres Incorporated with Ecklonia cava Phlorotannins Exhibit Excellent Cytocompatibility and Accelerate Hyperglycaemic Wound Healing
Conclusion:Taken together, our findings show that phlorotannin nanofibres have the potential to be used as a diabetic wound dressing. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 21, 2023 Category: Biotechnology Source Type: research

A Review of the Role of Bioreactors for iPSCs-Based Tissue-Engineered Articular Cartilage
Conclusion:The use of mechanical and electrical stimulation to differentiate iPSCs, and maintain and test chondrocytes are key stimuli influencing hyaline cartilage homeostasis. Incorporating these stimuli to bioreactors can positively impact cartilage TE approaches and their possibility for posterior translation into the clinics. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 20, 2023 Category: Biotechnology Source Type: research

Effect of Silicon Dioxide and Magnesium Oxide on the Printability, Degradability, Mechanical Strength and Bioactivity of 3D Printed Poly (Lactic Acid)-Tricalcium Phosphate Composite Scaffolds
Conclusion:The PLA-10%TCP-10%SiO2 composite presented the most promising results, especially for bone tissue regeneration, due to its intense osteogenic behavior. PLA-10%TCP-10%SiO2 could be used as an alternative implant for bone tissue engineering application. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 19, 2023 Category: Biotechnology Source Type: research

Synovium-Derived Mesenchymal Stem Cell-Based Scaffold-Free Fibrocartilage Engineering for Bone –Tendon Interface Healing in an Anterior Cruciate Ligament Reconstruction Model
Conclusion:Scaffold-free, fibrocartilage engineering together with tendon collagenase treatment enhanced fibrocartilaginous BTI healing in ACL reconstruction. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 19, 2023 Category: Biotechnology Source Type: research

Atelocollagen Scaffold Enhances Cartilage Regeneration in Osteochondral Defects: A Study in Rabbits
Conclusion:The results showed that implantation of the atelocollagen scaffold enhanced cartilage regeneration following osteochondral defects in rabbits. This suggests that the atelocollagen scaffold can be used with Mfx or BMAC for effective regeneration of osteochondral defects. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 18, 2023 Category: Biotechnology Source Type: research

Cassia Angustifolia Primed ASCs Accelerate Burn Wound Healing by Modulation of Inflammatory Response
Conclusion:SM priming effectively enabled ASCs to counter thermal injury by significantly enhancing cell survival and reducing inflammation upon transplantation. This study provides bases for development of effective combinational therapies (natural scaffold, medicine, and stem cells) with clinical prospects for treating burn wounds. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 17, 2023 Category: Biotechnology Source Type: research

Development of an In Vitro Model for Inflammation Mediated Renal Toxicity Using 3D Renal Tubules and Co-Cultured Human Immune Cells
Conclusion:The model demonstrated similar changes in kidney injury markers following polyI:C and LPS treatment, indicating its suitability for detecting immune-associated kidney damage resulting from infections and biopharmaceutical applications. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 16, 2023 Category: Biotechnology Source Type: research

Application of Cartilage Extracellular Matrix to Enhance Therapeutic Efficacy of Methotrexate
CONCLUSION:Using CECM as an adjuvant in RA treatment can augment the therapeutic effects of MTX, reduce existing drug adverse effects, and promote joint tissue regeneration. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 14, 2023 Category: Biotechnology Source Type: research

MiRNA320a Inhibitor-Loaded PLGA-PLL-PEG Nanoparticles Contribute to Bone Regeneration in Trauma-Induced Osteonecrosis Model of the Femoral Head
CONCLUSION:The miR-320a inhibitor-loaded PEG-PLGA-PLL nanoparticle sustained drug release system significantly contributed to bone regeneration in the TIONFH rabbit model, which might be a promising strategy for the treatment of TIONFH. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 12, 2023 Category: Biotechnology Source Type: research

The Effects of Injectable Platelet-Rich Fibrin and Advanced-Platelet Rich Fibrin on Gingival Fibroblast Cell Vitality, Proliferation, Differentiation
Conclusion:Both I-PRF and A-PRF induced a stimulatory biological impact on the proliferation of human gingiva fibroblasts, with the latter demonstrating better capacity in facilitating the release of different growth factors. A-PRF also induced higher gene expression of p-ERK, MMP-1&MMP-3, and the proliferation of fibroblasts. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 12, 2023 Category: Biotechnology Source Type: research

AuNP-Loaded Electrospinning Membrane Cooperated with CDs for Periodontal Tissue Engineering
Conclusion:The synergistic effect of loaded AuNPs electrospun fiber membrane with CDs can promote periodontal bone regeneration and exert antibacterial activity. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 12, 2023 Category: Biotechnology Source Type: research