Greater adherence to a mediterranean diet is associated with lower C-reactive protein (CRP) levels, but not to lower odds of having dry eye disease
CONCLUSIONS: Stronger adherence to a Mediterranean diet does not appear to be associated with lower odds of having DED in the general population. Furthermore, there was no association between hsCRP and DED in this study. However, the previously described link between a Mediterranean diet and lower hsCRP was confirmed in this large population-based study.PMID:37783428 | DOI:10.1016/j.jtos.2023.09.013 (Source: The Ocular Surface)
Source: The Ocular Surface - October 2, 2023 Category: Opthalmology Authors: Morten Schjerven Magno Emily Moschowits Mathias Kaurstad Morthen Marie Wangen Beining Nomdo M Jansonius Christopher J Hammond Tor P Utheim Jelle Vehof Source Type: research
New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering
CONCLUSION: 3D-CR can be used to study the lacrimal gland microstructure, help fabricate a 3D scaffold for lacrimal gland bioprinting, and serve as guide for transconjunctival lacrimal gland targeted therapies i.e., 2.9 & 9 mm long needle to reach the orbital and palpebral lobe center, respectively.PMID:37774917 | DOI:10.1016/j.jtos.2023.09.010 (Source: The Ocular Surface)
Source: The Ocular Surface - September 29, 2023 Category: Opthalmology Authors: Swati Singh Zoltan Winter Fabian Necker Tobias B äuerle Michael Scholz Lars Br äuer Friedrich Paulsen Source Type: research
New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering
CONCLUSION: 3D-CR can be used to study the lacrimal gland microstructure, help fabricate a 3D scaffold for lacrimal gland bioprinting, and serve as guide for transconjunctival lacrimal gland targeted therapies i.e., 2.9 & 9 mm long needle to reach the orbital and palpebral lobe center, respectively.PMID:37774917 | DOI:10.1016/j.jtos.2023.09.010 (Source: The Ocular Surface)
Source: The Ocular Surface - September 29, 2023 Category: Opthalmology Authors: Swati Singh Zoltan Winter Fabian Necker Tobias B äuerle Michael Scholz Lars Br äuer Friedrich Paulsen Source Type: research
New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering
CONCLUSION: 3D-CR can be used to study the lacrimal gland microstructure, help fabricate a 3D scaffold for lacrimal gland bioprinting, and serve as guide for transconjunctival lacrimal gland targeted therapies i.e., 2.9 & 9 mm long needle to reach the orbital and palpebral lobe center, respectively.PMID:37774917 | DOI:10.1016/j.jtos.2023.09.010 (Source: The Ocular Surface)
Source: The Ocular Surface - September 29, 2023 Category: Opthalmology Authors: Swati Singh Zoltan Winter Fabian Necker Tobias B äuerle Michael Scholz Lars Br äuer Friedrich Paulsen Source Type: research
Genomic DNA activates the AIM2 inflammasome and STING pathways to induce inflammation in lacrimal gland myoepithelial cells
CONCLUSION: Self-gDNA induces a proinflammatory response in lacrimal gland MECs by activating both the AIM2 inflammasome and STING and thus may contribute to the pathogenesis of pSS.PMID:37769964 | DOI:10.1016/j.jtos.2023.09.012 (Source: The Ocular Surface)
Source: The Ocular Surface - September 28, 2023 Category: Opthalmology Authors: Menglu Yang Vanessa Delcroix Anton Lennikov Nicholas Wang Helen P Makarenkova Darlene A Dartt Source Type: research
Genomic DNA activates the AIM2 inflammasome and STING pathways to induce inflammation in lacrimal gland myoepithelial cells
CONCLUSION: Self-gDNA induces a proinflammatory response in lacrimal gland MECs by activating both the AIM2 inflammasome and STING and thus may contribute to the pathogenesis of pSS.PMID:37769964 | DOI:10.1016/j.jtos.2023.09.012 (Source: The Ocular Surface)
Source: The Ocular Surface - September 28, 2023 Category: Opthalmology Authors: Menglu Yang Vanessa Delcroix Anton Lennikov Nicholas Wang Helen P Makarenkova Darlene A Dartt Source Type: research
Intrastromal versus subconjunctival injection of mesenchymal stem/stromal cells for promoting corneal repair
CONCLUSIONS: Although the injection of hBM-MSC using both intrastromal and subconjunctival methods improve wound healing and reduce neovascularization and opacity, the intrastromal approach is superior in terms of corneal healing.PMID:37758115 | DOI:10.1016/j.jtos.2023.09.008 (Source: The Ocular Surface)
Source: The Ocular Surface - September 27, 2023 Category: Opthalmology Authors: Mohammad Soleimani Reza Mirshahi Kasra Cheraqpour Seyed Mahbod Baharnoori Hamed Massoumi Collin Chow Sumaiya Shahjahan Bita Momenaei Mohammad Javad Ashraf Raghuram Koganti Mahmoud Ghassemi Khandaker N Anwar Elmira Jalilian Ali R Djalilian Source Type: research
Evaluation of ocular neuropathic pain
CONCLUSION: Ocular pain questionnaires can potentially diagnose ocular neuropathic pain. Disease-specific questionnaires are limited to their target populations, and non-disease-specific ophthalmic questionnaires are unreliable. Further studies are required to determine the most appropriate questionnaire to evaluate ocular neuropathic pain.PMID:37748645 | DOI:10.1016/j.jtos.2023.09.009 (Source: The Ocular Surface)
Source: The Ocular Surface - September 25, 2023 Category: Opthalmology Authors: Damien Tuan-Man Le Himal Kandel Stephanie L Watson Source Type: research
Evaluation of ocular neuropathic pain
CONCLUSION: Ocular pain questionnaires can potentially diagnose ocular neuropathic pain. Disease-specific questionnaires are limited to their target populations, and non-disease-specific ophthalmic questionnaires are unreliable. Further studies are required to determine the most appropriate questionnaire to evaluate ocular neuropathic pain.PMID:37748645 | DOI:10.1016/j.jtos.2023.09.009 (Source: The Ocular Surface)
Source: The Ocular Surface - September 25, 2023 Category: Opthalmology Authors: Damien Tuan-Man Le Himal Kandel Stephanie L Watson Source Type: research
Evaluation of ocular neuropathic pain
CONCLUSION: Ocular pain questionnaires can potentially diagnose ocular neuropathic pain. Disease-specific questionnaires are limited to their target populations, and non-disease-specific ophthalmic questionnaires are unreliable. Further studies are required to determine the most appropriate questionnaire to evaluate ocular neuropathic pain.PMID:37748645 | DOI:10.1016/j.jtos.2023.09.009 (Source: The Ocular Surface)
Source: The Ocular Surface - September 25, 2023 Category: Opthalmology Authors: Damien Tuan-Man Le Himal Kandel Stephanie L Watson Source Type: research
Rational design and synthesis of lumican stapled peptides for promoting corneal wound healing
CONCLUSIONS: Highly stable and non-toxic stapled peptides designed based on LumC13, significantly promote corneal wound healing. As a proof of principle, our data shows that more stable and pharmacologically relevant peptides can be designed based on endogenous peptide sequences for treating various corneal pathologies.PMID:37742739 | DOI:10.1016/j.jtos.2023.09.007 (Source: The Ocular Surface)
Source: The Ocular Surface - September 24, 2023 Category: Opthalmology Authors: Sudhir Verma Fernando T Ogata Isabel Y Moreno Cassio Prinholato da Silva Tainah Dorina Marforio Matteo Calvaresi Mehmet Sen Vivien J Coulson-Thomas Tarsis Ferreira Gesteira Source Type: research
Murine models of graft versus host disease (GVHD): Focus on ocular GVHD
Ocul Surf. 2023 Sep 22:S1542-0124(23)00124-6. doi: 10.1016/j.jtos.2023.09.006. Online ahead of print.ABSTRACTGraft versus host disease (GVHD) remains a major and serious complication of allogeneic hematopoietic stem cell transplantation. Based on the time of onset, clinical phenotypes, progression kinetics, and pathophysiology, GVHD is stratified into acute, chronic, and overlapping types. The eyes are among the most commonly affected organs in GVHD. Mouse models have played an important role in understanding the several key elements of GVHD pathobiology. The current review discusses the immunology, pathology, and key phen...
Source: The Ocular Surface - September 24, 2023 Category: Opthalmology Authors: Philipp Steven Victor L Perez Ajay Sharma Source Type: research
Topical formulations of Aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration
CONCLUSIONS: Aprepitant X formulation is a promising candidate for the treatment of pain associated with inflammation of the ocular surface.PMID:37690516 | DOI:10.1016/j.jtos.2023.09.004 (Source: The Ocular Surface)
Source: The Ocular Surface - September 10, 2023 Category: Opthalmology Authors: Filippo Bonelli Ibrahim Demirsoy Romina Mayra Lasagni Vitar Philippe Fonteyne Giulio Ferrari Source Type: research
Conjunctival transcriptomics in ocular mucous membrane pemphigoid
CONCLUSIONS: NanoString methodology acquired via a simple conjunctival swab identifies profibrotic genes in OcMMP group and differentiates inflamed eyes. Longitudinal sampling and following investigative intervention will further mechanistic insight and development of novel biomarkers to monitor disease progression.PMID:37690517 | DOI:10.1016/j.jtos.2023.09.005 (Source: The Ocular Surface)
Source: The Ocular Surface - September 10, 2023 Category: Opthalmology Authors: Jesse Panthagani Kusy Suleiman Rachel C Vincent Hon Shing Ong Graham R Wallace Saaeha Rauz Source Type: research
Topical formulations of Aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration
CONCLUSIONS: Aprepitant X formulation is a promising candidate for the treatment of pain associated with inflammation of the ocular surface.PMID:37690516 | DOI:10.1016/j.jtos.2023.09.004 (Source: The Ocular Surface)
Source: The Ocular Surface - September 10, 2023 Category: Opthalmology Authors: Filippo Bonelli Ibrahim Demirsoy Romina Mayra Lasagni Vitar Philippe Fonteyne Giulio Ferrari Source Type: research
