TFOS lifestyle report executive summary: A lifestyle epidemic - Ocular surface disease
This article presents an Executive Summary of the evidence-based conclusions and recommendations of the 10-chapter TFOS Lifestyle Workshop report. Lifestyle factors described within the report include contact lenses, cosmetics, digital environment, elective medications and procedures, environmental conditions, lifestyle challenges, nutrition, and societal challenges. Each topic area chapter comprises a narrative-style review of the current literature and seeks to answer a key topic-specific question using systematic review methodology. The TFOS Lifestyle Workshop report was published in its entirety in the April 2023 and J...
Source: The Ocular Surface - September 2, 2023 Category: Opthalmology Authors: Jennifer P Craig Monica Alves James S Wolffsohn Laura E Downie Nathan Efron Anat Galor Jos é Alvaro P Gomes Lyndon Jones Maria Markoulli Fiona Stapleton Christopher E Starr Amy Gallant Sullivan Mark D P Willcox David A Sullivan Source Type: research
TFOS lifestyle report executive summary: A lifestyle epidemic - Ocular surface disease
This article presents an Executive Summary of the evidence-based conclusions and recommendations of the 10-chapter TFOS Lifestyle Workshop report. Lifestyle factors described within the report include contact lenses, cosmetics, digital environment, elective medications and procedures, environmental conditions, lifestyle challenges, nutrition, and societal challenges. Each topic area chapter comprises a narrative-style review of the current literature and seeks to answer a key topic-specific question using systematic review methodology. The TFOS Lifestyle Workshop report was published in its entirety in the April 2023 and J...
Source: The Ocular Surface - September 2, 2023 Category: Opthalmology Authors: Jennifer P Craig Monica Alves James S Wolffsohn Laura E Downie Nathan Efron Anat Galor Jos é Alvaro P Gomes Lyndon Jones Maria Markoulli Fiona Stapleton Christopher E Starr Amy Gallant Sullivan Mark D P Willcox David A Sullivan Source Type: research
Glycosaminoglycans: Roles in wound healing, formation of corneal constructs and synthetic corneas
Ocul Surf. 2023 Aug 30:S1542-0124(23)00116-7. doi: 10.1016/j.jtos.2023.08.008. Online ahead of print.ABSTRACTMaintaining the clarity of the cornea is essential for vision, and is achieved through an exquisite array of collagen fibrils and proteoglycans in the corneal stroma. Alterations in the identity and modifications of the glycosaminoglycans (GAGs) are seen both throughout the normal wound healing process and in pathological conditions resulting in corneal opacity. Understanding these changes has been essential for the development of corneal prostheses and corneal reconstruction. The goal of this review article is to s...
Source: The Ocular Surface - September 1, 2023 Category: Opthalmology Authors: Kristen L Segars Vickery Trinkaus-Randall Source Type: research
A cocktail of small molecules maintains the stemness and differentiation potential of conjunctival epithelial cells
CONCLUSION: Overall, our culture system can expand the conjunctival epithelial cells and retain their potential to differentiate into mature goblet cells, which provided a promising source of seed cells for conjunctival reconstruction. Furthermore, this system provides new insights for the clinical treatment of ocular surface diseases.PMID:37634570 | DOI:10.1016/j.jtos.2023.08.005 (Source: The Ocular Surface)
Source: The Ocular Surface - August 27, 2023 Category: Opthalmology Authors: Lina Xu Guoliang Wang Ruize Shi Baihui Zeng Yan Zhang Zhen Liu Nuo Dong Shurong Wang Cheng Li Source Type: research
TNF is a critical cytokine in age-related dry eye disease
Ocul Surf. 2023 Aug 25:S1542-0124(23)00108-8. doi: 10.1016/j.jtos.2023.08.004. Online ahead of print.ABSTRACTAging is a complex biological process that is characterized by low-grade inflammation, called inflammaging. Aging affects multiple organs including eye and lacrimal gland. Tumor necrosis factor (TNF) is a pleiotropic cytokine that participates in inflammation, activation of proteases such as cathepsin S, and formation of ectopic lymphoid organs. Using genetic and pharmacological approaches, we investigated the role of TNF in age-related dry eye disease, emphasizing the ocular surface and lacrimal gland inflammation....
Source: The Ocular Surface - August 27, 2023 Category: Opthalmology Authors: Yashaswini Kelagere Kaitlin K Scholand Erica N DeJong Andrea I Boyd Zhiyuan Yu Roger A Astley Michelle C Callegan Dawn Me Bowdish Helen P Makarenkova Cintia S de Paiva Source Type: research
A cocktail of small molecules maintains the stemness and differentiation potential of conjunctival epithelial cells
CONCLUSION: Overall, our culture system can expand the conjunctival epithelial cells and retain their potential to differentiate into mature goblet cells, which provided a promising source of seed cells for conjunctival reconstruction. Furthermore, this system provides new insights for the clinical treatment of ocular surface diseases.PMID:37634570 | DOI:10.1016/j.jtos.2023.08.005 (Source: The Ocular Surface)
Source: The Ocular Surface - August 27, 2023 Category: Opthalmology Authors: Lina Xu Guoliang Wang Ruize Shi Baihui Zeng Yan Zhang Zhen Liu Nuo Dong Shurong Wang Cheng Li Source Type: research
TNF is a critical cytokine in age-related dry eye disease
Ocul Surf. 2023 Aug 25:S1542-0124(23)00108-8. doi: 10.1016/j.jtos.2023.08.004. Online ahead of print.ABSTRACTAging is a complex biological process that is characterized by low-grade inflammation, called inflammaging. Aging affects multiple organs including eye and lacrimal gland. Tumor necrosis factor (TNF) is a pleiotropic cytokine that participates in inflammation, activation of proteases such as cathepsin S, and formation of ectopic lymphoid organs. Using genetic and pharmacological approaches, we investigated the role of TNF in age-related dry eye disease, emphasizing the ocular surface and lacrimal gland inflammation....
Source: The Ocular Surface - August 27, 2023 Category: Opthalmology Authors: Yashaswini Kelagere Kaitlin K Scholand Erica N DeJong Andrea I Boyd Zhiyuan Yu Roger A Astley Michelle C Callegan Dawn Me Bowdish Helen P Makarenkova Cintia S de Paiva Source Type: research
A cocktail of small molecules maintains the stemness and differentiation potential of conjunctival epithelial cells
CONCLUSION: Overall, our culture system can expand the conjunctival epithelial cells and retain their potential to differentiate into mature goblet cells, which provided a promising source of seed cells for conjunctival reconstruction. Furthermore, this system provides new insights for the clinical treatment of ocular surface diseases.PMID:37634570 | DOI:10.1016/j.jtos.2023.08.005 (Source: The Ocular Surface)
Source: The Ocular Surface - August 27, 2023 Category: Opthalmology Authors: Lina Xu Guoliang Wang Ruize Shi Baihui Zeng Yan Zhang Zhen Liu Nuo Dong Shurong Wang Cheng Li Source Type: research
TNF is a critical cytokine in age-related dry eye disease
Ocul Surf. 2023 Aug 25:S1542-0124(23)00108-8. doi: 10.1016/j.jtos.2023.08.004. Online ahead of print.ABSTRACTAging is a complex biological process that is characterized by low-grade inflammation, called inflammaging. Aging affects multiple organs including eye and lacrimal gland. Tumor necrosis factor (TNF) is a pleiotropic cytokine that participates in inflammation, activation of proteases such as cathepsin S, and formation of ectopic lymphoid organs. Using genetic and pharmacological approaches, we investigated the role of TNF in age-related dry eye disease, emphasizing the ocular surface and lacrimal gland inflammation....
Source: The Ocular Surface - August 27, 2023 Category: Opthalmology Authors: Yashaswini Kelagere Kaitlin K Scholand Erica N DeJong Andrea I Boyd Zhiyuan Yu Roger A Astley Michelle C Callegan Dawn Me Bowdish Helen P Makarenkova Cintia S de Paiva Source Type: research
A cocktail of small molecules maintains the stemness and differentiation potential of conjunctival epithelial cells
CONCLUSION: Overall, our culture system can expand the conjunctival epithelial cells and retain their potential to differentiate into mature goblet cells, which provided a promising source of seed cells for conjunctival reconstruction. Furthermore, this system provides new insights for the clinical treatment of ocular surface diseases.PMID:37634570 | DOI:10.1016/j.jtos.2023.08.005 (Source: The Ocular Surface)
Source: The Ocular Surface - August 27, 2023 Category: Opthalmology Authors: Lina Xu Guoliang Wang Ruize Shi Baihui Zeng Yan Zhang Zhen Liu Nuo Dong Shurong Wang Cheng Li Source Type: research
TNF is a critical cytokine in age-related dry eye disease
Ocul Surf. 2023 Aug 25:S1542-0124(23)00108-8. doi: 10.1016/j.jtos.2023.08.004. Online ahead of print.ABSTRACTAging is a complex biological process that is characterized by low-grade inflammation, called inflammaging. Aging affects multiple organs including eye and lacrimal gland. Tumor necrosis factor (TNF) is a pleiotropic cytokine that participates in inflammation, activation of proteases such as cathepsin S, and formation of ectopic lymphoid organs. Using genetic and pharmacological approaches, we investigated the role of TNF in age-related dry eye disease, emphasizing the ocular surface and lacrimal gland inflammation....
Source: The Ocular Surface - August 27, 2023 Category: Opthalmology Authors: Yashaswini Kelagere Kaitlin K Scholand Erica N DeJong Andrea I Boyd Zhiyuan Yu Roger A Astley Michelle C Callegan Dawn Me Bowdish Helen P Makarenkova Cintia S de Paiva Source Type: research
A cocktail of small molecules maintains the stemness and differentiation potential of conjunctival epithelial cells
CONCLUSION: Overall, our culture system can expand the conjunctival epithelial cells and retain their potential to differentiate into mature goblet cells, which provided a promising source of seed cells for conjunctival reconstruction. Furthermore, this system provides new insights for the clinical treatment of ocular surface diseases.PMID:37634570 | DOI:10.1016/j.jtos.2023.08.005 (Source: The Ocular Surface)
Source: The Ocular Surface - August 27, 2023 Category: Opthalmology Authors: Lina Xu Guoliang Wang Ruize Shi Baihui Zeng Yan Zhang Zhen Liu Nuo Dong Shurong Wang Cheng Li Source Type: research
TNF is a critical cytokine in age-related dry eye disease
Ocul Surf. 2023 Aug 25:S1542-0124(23)00108-8. doi: 10.1016/j.jtos.2023.08.004. Online ahead of print.ABSTRACTAging is a complex biological process that is characterized by low-grade inflammation, called inflammaging. Aging affects multiple organs including eye and lacrimal gland. Tumor necrosis factor (TNF) is a pleiotropic cytokine that participates in inflammation, activation of proteases such as cathepsin S, and formation of ectopic lymphoid organs. Using genetic and pharmacological approaches, we investigated the role of TNF in age-related dry eye disease, emphasizing the ocular surface and lacrimal gland inflammation....
Source: The Ocular Surface - August 27, 2023 Category: Opthalmology Authors: Yashaswini Kelagere Kaitlin K Scholand Erica N DeJong Andrea I Boyd Zhiyuan Yu Roger A Astley Michelle C Callegan Dawn Me Bowdish Helen P Makarenkova Cintia S de Paiva Source Type: research
Dry eye disease sustainability
Ocul Surf. 2023 Aug 22:S1542-0124(23)00114-3. doi: 10.1016/j.jtos.2023.08.006. Online ahead of print.NO ABSTRACTPMID:37619668 | DOI:10.1016/j.jtos.2023.08.006 (Source: The Ocular Surface)
Source: The Ocular Surface - August 24, 2023 Category: Opthalmology Authors: Francesc March de Ribot Jose M Benitez Del Castillo Gerd Geerling Elisabeth Messmer Christophe Baudouin Monica Alves Source Type: research
Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction
CONCLUSIONS: In this study, a stable organotypic culture model of the MGs was established. The organotypic culture model offers a valuable tool to investigate the pathophysiological mechanisms and facilitate drug screening for MG-related diseases.PMID:37619669 | DOI:10.1016/j.jtos.2023.08.007 (Source: The Ocular Surface)
Source: The Ocular Surface - August 24, 2023 Category: Opthalmology Authors: Guoliang Wang Lina Xu Ruize Shi Yingyue Ye Baihui Zeng Xiuqin Yang Zeyu Liu Zhen Liu Shurong Wang Yuhua Xue Cheng Li Source Type: research
