Short chain fatty acids inhibit corneal inflammatory responses to TLR ligands via the ocular G-protein coupled receptor 43
CONCLUSIONS: This is the first report to demonstrate of the protective effect of SCFAs on microbial keratitis, and the dynamic expression and anti-inflammatory function of GPR43 in the eye. SCFAs can modulate inflammation and immunity in the eye through GPR43.PMID:38224777 | DOI:10.1016/j.jtos.2024.01.005 (Source: The Ocular Surface)
Source: The Ocular Surface - January 15, 2024 Category: Opthalmology Authors: Jun Wu Nu Chen Elizabeth Grau Luke Johnson Yongqing Liu Chi Li Patrick A Scott Chang Kim Deming Sun Henry J Kaplan Hui Shao Source Type: research
Self-complementary AAV vector therapy for treating corneal cloudiness of mucopolysaccharidosis type VII (MPS VII)
CONCLUSION: Intrahepatic injection of scAAV-Gusb is efficacious in prolonging the life span of Gusb mice, and intrastromal injection can ameliorate corneal phenotypes. Both strategies can be adapted for treating other MPS.PMID:38218582 | DOI:10.1016/j.jtos.2024.01.002 (Source: The Ocular Surface)
Source: The Ocular Surface - January 13, 2024 Category: Opthalmology Authors: Jhuwala Venkatakrishnan Yong Yuan Jianhua Zhang Yang Yu Yueh-Chiang Hu Winston W-Y Kao Source Type: research
Tissue-targeted and localized AAV5-DCN and AAV5-PEDF combination gene therapy abrogates corneal fibrosis and concurrent neovascularization in rabbit eyes in vivo
CONCLUSION: The combination AAV5-DCN and AAV5-PEDF topical gene therapy effectively reduces corneal fibrosis and CNV with high tolerability in vivo in rabbits. Additional studies are warranted.PMID:38191093 | DOI:10.1016/j.jtos.2024.01.001 (Source: The Ocular Surface)
Source: The Ocular Surface - January 8, 2024 Category: Opthalmology Authors: Rajiv R Mohan Suneel Gupta Rajnish Kumar Nishant R Sinha James Landreneau Prashant R Sinha Ashish Tandon Shyam S Chaurasia Nathan P Hesemann Source Type: research
Tissue-targeted and localized AAV5-DCN and AAV5-PEDF combination gene therapy abrogates corneal fibrosis and concurrent neovascularization in rabbit eyes in vivo
CONCLUSION: The combination AAV5-DCN and AAV5-PEDF topical gene therapy effectively reduces corneal fibrosis and CNV with high tolerability in vivo in rabbits. Additional studies are warranted.PMID:38191093 | DOI:10.1016/j.jtos.2024.01.001 (Source: The Ocular Surface)
Source: The Ocular Surface - January 8, 2024 Category: Opthalmology Authors: Rajiv R Mohan Suneel Gupta Rajnish Kumar Nishant R Sinha James Landreneau Prashant R Sinha Ashish Tandon Shyam S Chaurasia Nathan P Hesemann Source Type: research
Endogenous TSG-6 modulates corneal inflammation following chemical injury
CONCLUSION: TSG-6 is endogenously expressed in the cornea and upregulated after injury where it propagates the inflammatory response following chemical injury.PMID:38151073 | DOI:10.1016/j.jtos.2023.12.007 (Source: The Ocular Surface)
Source: The Ocular Surface - December 27, 2023 Category: Opthalmology Authors: Sudhir Verma Isabel Y Moreno Cassio Prinholato da Silva Mingxia Sun Xuhong Cheng Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Endogenous TSG-6 modulates corneal inflammation following chemical injury
CONCLUSION: TSG-6 is endogenously expressed in the cornea and upregulated after injury where it propagates the inflammatory response following chemical injury.PMID:38151073 | DOI:10.1016/j.jtos.2023.12.007 (Source: The Ocular Surface)
Source: The Ocular Surface - December 27, 2023 Category: Opthalmology Authors: Sudhir Verma Isabel Y Moreno Cassio Prinholato da Silva Mingxia Sun Xuhong Cheng Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Endogenous TSG-6 modulates corneal inflammation following chemical injury
CONCLUSION: TSG-6 is endogenously expressed in the cornea and upregulated after injury where it propagates the inflammatory response following chemical injury.PMID:38151073 | DOI:10.1016/j.jtos.2023.12.007 (Source: The Ocular Surface)
Source: The Ocular Surface - December 27, 2023 Category: Opthalmology Authors: Sudhir Verma Isabel Y Moreno Cassio Prinholato da Silva Mingxia Sun Xuhong Cheng Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Endogenous TSG-6 modulates corneal inflammation following chemical injury
CONCLUSION: TSG-6 is endogenously expressed in the cornea and upregulated after injury where it propagates the inflammatory response following chemical injury.PMID:38151073 | DOI:10.1016/j.jtos.2023.12.007 (Source: The Ocular Surface)
Source: The Ocular Surface - December 27, 2023 Category: Opthalmology Authors: Sudhir Verma Isabel Y Moreno Cassio Prinholato da Silva Mingxia Sun Xuhong Cheng Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Endogenous TSG-6 modulates corneal inflammation following chemical injury
CONCLUSION: TSG-6 is endogenously expressed in the cornea and upregulated after injury where it propagates the inflammatory response following chemical injury.PMID:38151073 | DOI:10.1016/j.jtos.2023.12.007 (Source: The Ocular Surface)
Source: The Ocular Surface - December 27, 2023 Category: Opthalmology Authors: Sudhir Verma Isabel Y Moreno Cassio Prinholato da Silva Mingxia Sun Xuhong Cheng Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Endogenous TSG-6 modulates corneal inflammation following chemical injury
CONCLUSION: TSG-6 is endogenously expressed in the cornea and upregulated after injury where it propagates the inflammatory response following chemical injury.PMID:38151073 | DOI:10.1016/j.jtos.2023.12.007 (Source: The Ocular Surface)
Source: The Ocular Surface - December 27, 2023 Category: Opthalmology Authors: Sudhir Verma Isabel Y Moreno Cassio Prinholato da Silva Mingxia Sun Xuhong Cheng Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Endogenous TSG-6 modulates corneal inflammation following chemical injury
CONCLUSION: TSG-6 is endogenously expressed in the cornea and upregulated after injury where it propagates the inflammatory response following chemical injury.PMID:38151073 | DOI:10.1016/j.jtos.2023.12.007 (Source: The Ocular Surface)
Source: The Ocular Surface - December 27, 2023 Category: Opthalmology Authors: Sudhir Verma Isabel Y Moreno Cassio Prinholato da Silva Mingxia Sun Xuhong Cheng Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Endogenous TSG-6 modulates corneal inflammation following chemical injury
CONCLUSION: TSG-6 is endogenously expressed in the cornea and upregulated after injury where it propagates the inflammatory response following chemical injury.PMID:38151073 | DOI:10.1016/j.jtos.2023.12.007 (Source: The Ocular Surface)
Source: The Ocular Surface - December 27, 2023 Category: Opthalmology Authors: Sudhir Verma Isabel Y Moreno Cassio Prinholato da Silva Mingxia Sun Xuhong Cheng Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Endogenous TSG-6 modulates corneal inflammation following chemical injury
CONCLUSION: TSG-6 is endogenously expressed in the cornea and upregulated after injury where it propagates the inflammatory response following chemical injury.PMID:38151073 | DOI:10.1016/j.jtos.2023.12.007 (Source: The Ocular Surface)
Source: The Ocular Surface - December 27, 2023 Category: Opthalmology Authors: Sudhir Verma Isabel Y Moreno Cassio Prinholato da Silva Mingxia Sun Xuhong Cheng Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
A closer look into the cellular and molecular biology of myoepithelial cells across various exocrine glands
Ocul Surf. 2023 Dec 21:S1542-0124(23)00153-2. doi: 10.1016/j.jtos.2023.12.003. Online ahead of print.ABSTRACTMyoepithelial cells (MECs) are a unique subset of epithelial cells that possess several smooth muscle cell characteristics, such as a high number of actin-myosin filaments and the ability to contract. These cells are primarily located around the secretory cells of exocrine glands, including the salivary, mammary, lacrimal, and sweat glands. Their primary functions involve the construction of the basement membrane and help with secretion of gland products through contraction. So far, no comparative analysis of MECs i...
Source: The Ocular Surface - December 23, 2023 Category: Opthalmology Authors: Olivier Mauduit Vanessa Delcroix Andrew Wong Anastasiia Ivanova Hyun Soo Lee Helen Makarenkova Source Type: research
Ocular surface changes in mice with streptozotocin-induced diabetes and diabetic polyneuropathy
CONCLUSION: The early ocular changes in DM Mice only affect the lacrimal gland. Which, is reflected in the tear film composition of DPN mice. Due to the high protein concentration in tear fluid in humans, proteomic analysis in addition to noninvasive investigation of goblet cells and cornea can serve as a tools for the early diagnosis of DPN, DED in clinical practice. Early treatment could delay or even prevent the ocular complications of DM such as DED and PN.PMID:38141818 | DOI:10.1016/j.jtos.2023.12.006 (Source: The Ocular Surface)
Source: The Ocular Surface - December 23, 2023 Category: Opthalmology Authors: Martin Schicht Jessica Farger Saskia Wedel Marco Sisignano Klaus Scholich Gerd Geisslinger Natarajan Perumal Franz H Grus Swati Singh Afsun Sahin Friedrich Paulsen Elke L ütjen-Drecoll Source Type: research
