Genomic DNA activates the AIM2 inflammasome and STING pathways to induce inflammation in lacrimal gland myoepithelial cells

CONCLUSION: Self-gDNA induces a proinflammatory response in lacrimal gland MECs by activating both the AIM2 inflammasome and STING and thus may contribute to the pathogenesis of pSS.PMID:37769964 | DOI:10.1016/j.jtos.2023.09.012

Source: The Ocular Surface - September 28, 2023 Category: Opthalmology Authors: Menglu Yang Vanessa Delcroix Anton Lennikov Nicholas Wang Helen P Makarenkova Darlene A Dartt Source Type: research