Recurrent Syncope Caused by a Dural Arteriovenous Fistula: A Case Report and Review of the Literature
Conclusion:
We present an atypical case of DAVF in a patient presenting with recurrent syncope. Only 4 cases of DAVF causing syncope have been reported, all in combination with other neurological symptoms. In comparison, we report a unique case of DAVF presenting solely with recurrent syncope, a previously undocumented finding in the literature. Our case adds to other reports of nonspecific DAVF presentations and highlights the importance of considering this etiology. (Source: The Neurologist)
Source: The Neurologist - March 1, 2021 Category: Neurology Tags: Case Report/Case Series Source Type: research
Alzheimer Disease Clinical Trials Targeting Amyloid: Lessons Learned From Success in Mice and Failure in Humans
Conclusion:
Lessons learned from clinical trials of amyloid reduction strategies may prove crucial for the leap forward toward novel therapeutic targets to treat AD. (Source: The Neurologist)
Source: The Neurologist - March 1, 2021 Category: Neurology Tags: Review Article Source Type: research
Does General Anesthesia Compared With Conscious Sedation Result in Better Outcomes in Acute Stroke Patients Undergoing Endovascular Therapy?
Conclusions:
GA does not result in worse tissue outcomes or worse clinical outcomes when compared with CS in acute stroke patients with large vessel occlusion undergoing mechanical thrombectomy. (Source: The Neurologist)
Source: The Neurologist - March 1, 2021 Category: Neurology Tags: Critically Appraised Topics Source Type: research
A Novel Fast CT Perfusion Core-Penumbra Mismatch Score: Correlation With Stroke Outcome
Conclusions:
The authors proposed a novel immediate CTP assessment to score perfusion mismatch in emergency settings to guide clinicians’ decision-making for aggressive treatment and to prevent stroke-related disability. (Source: The Neurologist)
Source: The Neurologist - March 1, 2021 Category: Neurology Tags: Original Articles Source Type: research
Neurologists’ Diagnostic Accuracy and Interspecialties’ Diagnostic Concordance of Acute Vertigo: Observational Study at the Emergency Department in a Tertiary Center
Background:
Acute vertigo (AV) is often a challenging condition. Because of its multiple causes, patients are frequently observed by neurologists and physicians from other areas of specialites, particularly Ear, Nose, and Throat (ENT). We aimed to assess the diagnostic accuracy of AV in patients observed by Neurology and other medical specialties.
Materials and Methods:
Retrospective cross-sectional study with the selection of all patients with AV observed by Neurology at the Emergency Department (ED) of a tertiary center in 2019, regarding demographic data, imaging studies, diagnosis by Neurology and ENT at the...
Source: The Neurologist - March 1, 2021 Category: Neurology Tags: Original Articles Source Type: research
Phospholipase A2 and Ischemic Stroke Etiology
Background:
Lipoprotein-associated phospholipase A2 (Lp-PLA2), which is involved in the inflammatory atherosclerotic process, has emerged as an independent risk factor for atheromatous vascular events. Its impact on coronary disease has already been demonstrated, however, its influence in cerebrovascular etiology is still unknown. We aimed to observe and describe the potential association between Lp-PLA2 levels and the etiologic subtype of ischemic stroke.
Methods:
Unicentric, observational, and prospective cohort study of consecutive patients with acute ischemic stroke, admitted in a comprehensive stroke center...
Source: The Neurologist - March 1, 2021 Category: Neurology Tags: Original Articles Source Type: research
Superoxide Dismutase Gene Polymorphism is Associated With Ischemic Stroke Risk in the China Dali Region Han Population
Conclusion:
The SOD3 gene rs7655372 locus polymorphism is a risk factor for IS in the Dali region. (Source: The Neurologist)
Source: The Neurologist - March 1, 2021 Category: Neurology Tags: Original Articles Source Type: research
Acute Fluctuant Neurological Symptoms in Stable Chronic Cryptococcus gattii Cryptococcomas: A Novel Disease Complication
Conclusions:
Central nervous system cryptococcomas are difficult to treat, chronic infections, that in our patient had lasted over 10 years despite treatment compliance. A true cryptococcal meningitis relapse is indicated by positive cell cultures in previously sterile fluid but cryptococcoma progression is measured by serial magnetic resonance imaging or computed tomography scans. In the case of progression or relapse induction and consolidation therapy should be restarted. Our patient demonstrated neither relapse nor progression but presented with a novel disease complication of acute fluctuating neurology in chronic...
Source: The Neurologist - January 1, 2021 Category: Neurology Tags: Case Report/Case Series Source Type: research
Huge Free-Floating Thrombus in the Internal Carotid Artery Under Duplex Ultrasound Surveillance: A Case Report
Conclusions:
Evaluation of the intracranial vessel in the emergency is not enough and early carotid duplex ultrasound can help find of the FFT in time, which help to choose the early intervene by neurosurgeon. Early antithrombotic treatment can be a safe treatment option for reducing huge thrombus based on the nature of thrombus formation. Computed tomography angiography and high-resolution magnetic resonance imaging to certify the character of the plaque are recommended for plaque evaluation. (Source: The Neurologist)
Source: The Neurologist - January 1, 2021 Category: Neurology Tags: Case Report/Case Series Source Type: research
True Restriction in Diffusion-Weighted Imaging in a Mistreated Patient With Phenylketonuria
Discussion:
Cognitive dysfunction and psychiatric disorders can be present in adult patients with PKU who discontinue treatment and have poor PHE metabolic control. The presence of white matter hyperintensities in T2 and fluid-attenuated inversion recovery MRI-sequences is a well-described neuroimaging feature of PKU, but diffusion-weighted imaging sequence may also be reliable in detecting brain lesions in patients with PKU. PKU lesions should be considered in the differential diagnosis of true diffusion restriction in brain MRI of patients with PKU history or those who might have escaped newborn screening diagnosis b...
Source: The Neurologist - January 1, 2021 Category: Neurology Tags: Case Report/Case Series Source Type: research
Neurological Manifestations of SARS-CoV-2: A Narrative Review
Conclusions:
As subacute respiratory syndrome-coronavirus-2 may potentially have lethal implications on the nervous system, it is important that neurologists are better informed about the spectrum of clinical manifestations, radiologic findings, and likely mechanisms of injury. Understanding the symptoms and radiologic imaging allows clinicians to consider brain imaging in any patient with suspected COVID-19 and neurological symptoms. (Source: The Neurologist)
Source: The Neurologist - January 1, 2021 Category: Neurology Tags: Review Article Source Type: research
Comparative Evaluation of Stroke Awareness of Individuals Whose First-Degree Relatives had a Stroke and that of Individuals Whose First-Degree Relatives Did Not
Conclusion:
The present study can serve as a guide in planning training to improve stroke awareness in the future, especially by including individuals whose first-degree relatives had a stroke. (Source: The Neurologist)
Source: The Neurologist - January 1, 2021 Category: Neurology Tags: Original Articles Source Type: research
Effect of Low-Frequency rTMS and Intensive Speech Therapy Treatment on Patients With Nonfluent Aphasia After Stroke
Conclusions:
Low-frequency rTMS combined with conventional ST treatment can effectively improve the language function of patients with nonfluent aphasia after stroke. Two times a day low-frequency rTMS therapy combined with conventional ST treatment can improve the language function of patients with nonfluent aphasia after stroke more effectively and it also promote the expression of BDNF more effectively, thereby improving nerve repair and protecting brain tissue. (Source: The Neurologist)
Source: The Neurologist - January 1, 2021 Category: Neurology Tags: Original Articles Source Type: research
Predictors of Good Outcomes in Stroke Thrombolysis Guided by Tissue-Window
This study aimed to evaluate predictors of good outcomes from thrombolysis in these patients.
Methods:
Acute ischemic stroke patients received thrombolysis guided by computed tomography perfusion (CTP) from October 2018 to August 2019 were reviewed. Baseline characteristics and outcomes were collected. Good outcomes were defined as modified Rankin scale scores of 0 to 2 at 90 days. Logistic regression analysis was performed and the receiver operating characteristics analysis was used to determine cut-off values for the predictors of outcomes.
Results:
Sixty-three patients were enrolled. The median age was 64 ...
Source: The Neurologist - January 1, 2021 Category: Neurology Tags: Original Articles Source Type: research
Hirayama Disease Presenting as 4-Limb Paresthesia
Conclusions:
Laxity of the posterior dura during neck flexion has been postulated to lead to asymmetric lower cervical cord atrophy. Involvement of all 4 limbs is rare, and the condition can be mistaken for progressive multiple sclerosis. (Source: The Neurologist)
Source: The Neurologist - November 1, 2020 Category: Neurology Tags: Case Report/Case Series Source Type: research
