Activin E is a TGF β ligand that signals specifically through activin receptor-like kinase 7
Biochem J. 2024 Mar 27:BCJ20230404. doi: 10.1042/BCJ20230404. Online ahead of print.ABSTRACTActivins are one of the three distinct subclasses within the greater Transforming Growth Factor β (TGFβ) superfamily. First discovered for their critical roles in reproductive biology, activins have since been shown to alter cellular differentiation and proliferation. At present, members of the activin subclass include activin A (ActA), ActB, ActC, ActE, and the more distant members myostatin and GDF11. While the biological roles and signaling mechanisms of most activins class members have been well-studied, the signaling potentia...
Source: The Biochemical Journal - March 27, 2024 Category: Biochemistry Authors: Kylie A Vestal Chandramohan Kattamuri Muhasin Koyiloth Luisina Ongaro James A Howard Aimee Deaton Simina Ticau Aditi Dubey Daniel J Bernard Thomas B Thompson Source Type: research
Activin E is a TGF β ligand that signals specifically through activin receptor-like kinase 7
Biochem J. 2024 Mar 27:BCJ20230404. doi: 10.1042/BCJ20230404. Online ahead of print.ABSTRACTActivins are one of the three distinct subclasses within the greater Transforming Growth Factor β (TGFβ) superfamily. First discovered for their critical roles in reproductive biology, activins have since been shown to alter cellular differentiation and proliferation. At present, members of the activin subclass include activin A (ActA), ActB, ActC, ActE, and the more distant members myostatin and GDF11. While the biological roles and signaling mechanisms of most activins class members have been well-studied, the signaling potentia...
Source: The Biochemical Journal - March 27, 2024 Category: Biochemistry Authors: Kylie A Vestal Chandramohan Kattamuri Muhasin Koyiloth Luisina Ongaro James A Howard Aimee Deaton Simina Ticau Aditi Dubey Daniel J Bernard Thomas B Thompson Source Type: research
Activin E is a TGF β ligand that signals specifically through activin receptor-like kinase 7
Biochem J. 2024 Mar 27:BCJ20230404. doi: 10.1042/BCJ20230404. Online ahead of print.ABSTRACTActivins are one of the three distinct subclasses within the greater Transforming Growth Factor β (TGFβ) superfamily. First discovered for their critical roles in reproductive biology, activins have since been shown to alter cellular differentiation and proliferation. At present, members of the activin subclass include activin A (ActA), ActB, ActC, ActE, and the more distant members myostatin and GDF11. While the biological roles and signaling mechanisms of most activins class members have been well-studied, the signaling potentia...
Source: The Biochemical Journal - March 27, 2024 Category: Biochemistry Authors: Kylie A Vestal Chandramohan Kattamuri Muhasin Koyiloth Luisina Ongaro James A Howard Aimee Deaton Simina Ticau Aditi Dubey Daniel J Bernard Thomas B Thompson Source Type: research
The deubiquitinase function of ataxin-3 and its role in the pathogenesis of Machado-Joseph disease and other diseases
Biochem J. 2024 Mar 20;481(6):461-480. doi: 10.1042/BCJ20240017.ABSTRACTMachado-Joseph disease (MJD) is a devastating and incurable neurodegenerative disease characterised by progressive ataxia, difficulty speaking and swallowing. Consequently, affected individuals ultimately become wheelchair dependent, require constant care, and face a shortened life expectancy. The monogenic cause of MJD is expansion of a trinucleotide (CAG) repeat region within the ATXN3 gene, which results in polyglutamine (polyQ) expansion within the resultant ataxin-3 protein. While it is well established that the ataxin-3 protein functions as a deu...
Source: The Biochemical Journal - March 18, 2024 Category: Biochemistry Authors: Anastasiya Potapenko Jennilee M Davidson Albert Lee Angela S Laird Source Type: research
The deubiquitinase function of ataxin-3 and its role in the pathogenesis of Machado-Joseph disease and other diseases
Biochem J. 2024 Mar 20;481(6):461-480. doi: 10.1042/BCJ20240017.ABSTRACTMachado-Joseph disease (MJD) is a devastating and incurable neurodegenerative disease characterised by progressive ataxia, difficulty speaking and swallowing. Consequently, affected individuals ultimately become wheelchair dependent, require constant care, and face a shortened life expectancy. The monogenic cause of MJD is expansion of a trinucleotide (CAG) repeat region within the ATXN3 gene, which results in polyglutamine (polyQ) expansion within the resultant ataxin-3 protein. While it is well established that the ataxin-3 protein functions as a deu...
Source: The Biochemical Journal - March 18, 2024 Category: Biochemistry Authors: Anastasiya Potapenko Jennilee M Davidson Albert Lee Angela S Laird Source Type: research
The deubiquitinase function of ataxin-3 and its role in the pathogenesis of Machado-Joseph disease and other diseases
Biochem J. 2024 Mar 20;481(6):461-480. doi: 10.1042/BCJ20240017.ABSTRACTMachado-Joseph disease (MJD) is a devastating and incurable neurodegenerative disease characterised by progressive ataxia, difficulty speaking and swallowing. Consequently, affected individuals ultimately become wheelchair dependent, require constant care, and face a shortened life expectancy. The monogenic cause of MJD is expansion of a trinucleotide (CAG) repeat region within the ATXN3 gene, which results in polyglutamine (polyQ) expansion within the resultant ataxin-3 protein. While it is well established that the ataxin-3 protein functions as a deu...
Source: The Biochemical Journal - March 18, 2024 Category: Biochemistry Authors: Anastasiya Potapenko Jennilee M Davidson Albert Lee Angela S Laird Source Type: research
The deubiquitinase function of ataxin-3 and its role in the pathogenesis of Machado-Joseph disease and other diseases
Biochem J. 2024 Mar 20;481(6):461-480. doi: 10.1042/BCJ20240017.ABSTRACTMachado-Joseph disease (MJD) is a devastating and incurable neurodegenerative disease characterised by progressive ataxia, difficulty speaking and swallowing. Consequently, affected individuals ultimately become wheelchair dependent, require constant care, and face a shortened life expectancy. The monogenic cause of MJD is expansion of a trinucleotide (CAG) repeat region within the ATXN3 gene, which results in polyglutamine (polyQ) expansion within the resultant ataxin-3 protein. While it is well established that the ataxin-3 protein functions as a deu...
Source: The Biochemical Journal - March 18, 2024 Category: Biochemistry Authors: Anastasiya Potapenko Jennilee M Davidson Albert Lee Angela S Laird Source Type: research
The deubiquitinase function of ataxin-3 and its role in the pathogenesis of Machado-Joseph disease and other diseases
Biochem J. 2024 Mar 20;481(6):461-480. doi: 10.1042/BCJ20240017.ABSTRACTMachado-Joseph disease (MJD) is a devastating and incurable neurodegenerative disease characterised by progressive ataxia, difficulty speaking and swallowing. Consequently, affected individuals ultimately become wheelchair dependent, require constant care, and face a shortened life expectancy. The monogenic cause of MJD is expansion of a trinucleotide (CAG) repeat region within the ATXN3 gene, which results in polyglutamine (polyQ) expansion within the resultant ataxin-3 protein. While it is well established that the ataxin-3 protein functions as a deu...
Source: The Biochemical Journal - March 18, 2024 Category: Biochemistry Authors: Anastasiya Potapenko Jennilee M Davidson Albert Lee Angela S Laird Source Type: research
The deubiquitinase function of ataxin-3 and its role in the pathogenesis of Machado-Joseph disease and other diseases
Biochem J. 2024 Mar 20;481(6):461-480. doi: 10.1042/BCJ20240017.ABSTRACTMachado-Joseph disease (MJD) is a devastating and incurable neurodegenerative disease characterised by progressive ataxia, difficulty speaking and swallowing. Consequently, affected individuals ultimately become wheelchair dependent, require constant care, and face a shortened life expectancy. The monogenic cause of MJD is expansion of a trinucleotide (CAG) repeat region within the ATXN3 gene, which results in polyglutamine (polyQ) expansion within the resultant ataxin-3 protein. While it is well established that the ataxin-3 protein functions as a deu...
Source: The Biochemical Journal - March 18, 2024 Category: Biochemistry Authors: Anastasiya Potapenko Jennilee M Davidson Albert Lee Angela S Laird Source Type: research
The deubiquitinase function of ataxin-3 and its role in the pathogenesis of Machado-Joseph disease and other diseases
Biochem J. 2024 Mar 20;481(6):461-480. doi: 10.1042/BCJ20240017.ABSTRACTMachado-Joseph disease (MJD) is a devastating and incurable neurodegenerative disease characterised by progressive ataxia, difficulty speaking and swallowing. Consequently, affected individuals ultimately become wheelchair dependent, require constant care, and face a shortened life expectancy. The monogenic cause of MJD is expansion of a trinucleotide (CAG) repeat region within the ATXN3 gene, which results in polyglutamine (polyQ) expansion within the resultant ataxin-3 protein. While it is well established that the ataxin-3 protein functions as a deu...
Source: The Biochemical Journal - March 18, 2024 Category: Biochemistry Authors: Anastasiya Potapenko Jennilee M Davidson Albert Lee Angela S Laird Source Type: research
The deubiquitinase function of ataxin-3 and its role in the pathogenesis of Machado-Joseph disease and other diseases
Biochem J. 2024 Mar 20;481(6):461-480. doi: 10.1042/BCJ20240017.ABSTRACTMachado-Joseph disease (MJD) is a devastating and incurable neurodegenerative disease characterised by progressive ataxia, difficulty speaking and swallowing. Consequently, affected individuals ultimately become wheelchair dependent, require constant care, and face a shortened life expectancy. The monogenic cause of MJD is expansion of a trinucleotide (CAG) repeat region within the ATXN3 gene, which results in polyglutamine (polyQ) expansion within the resultant ataxin-3 protein. While it is well established that the ataxin-3 protein functions as a deu...
Source: The Biochemical Journal - March 18, 2024 Category: Biochemistry Authors: Anastasiya Potapenko Jennilee M Davidson Albert Lee Angela S Laird Source Type: research
Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2 α phosphorylation
Biochem J. 2024 Mar 5:BCJ20220531. doi: 10.1042/BCJ20220531. Online ahead of print.ABSTRACTThe protein kinase Gcn2 and its effector protein Gcn1 are part of the General Amino Acid Control signalling (GAAC) pathway best known in yeast for its function in maintaining amino acid homeostasis. Under amino acid limitation, Gcn2 becomes activated, subsequently increasing the levels of phosphorylated eIF2α (eIF2α-P). This leads to the increased translation of transcriptional regulators, such as Gcn4 in yeast and ATF4 in mammals, and subsequent re-programming of the cell's gene transcription profile, thereby allowing cells to cop...
Source: The Biochemical Journal - March 5, 2024 Category: Biochemistry Authors: Renuka Shanmugam Reuben Anderson Anja H Schiemann Evelyn Sattlegger Source Type: research
Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2 α phosphorylation
Biochem J. 2024 Mar 5:BCJ20220531. doi: 10.1042/BCJ20220531. Online ahead of print.ABSTRACTThe protein kinase Gcn2 and its effector protein Gcn1 are part of the General Amino Acid Control signalling (GAAC) pathway best known in yeast for its function in maintaining amino acid homeostasis. Under amino acid limitation, Gcn2 becomes activated, subsequently increasing the levels of phosphorylated eIF2α (eIF2α-P). This leads to the increased translation of transcriptional regulators, such as Gcn4 in yeast and ATF4 in mammals, and subsequent re-programming of the cell's gene transcription profile, thereby allowing cells to cop...
Source: The Biochemical Journal - March 5, 2024 Category: Biochemistry Authors: Renuka Shanmugam Reuben Anderson Anja H Schiemann Evelyn Sattlegger Source Type: research
Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2 α phosphorylation
Biochem J. 2024 Mar 5:BCJ20220531. doi: 10.1042/BCJ20220531. Online ahead of print.ABSTRACTThe protein kinase Gcn2 and its effector protein Gcn1 are part of the General Amino Acid Control signalling (GAAC) pathway best known in yeast for its function in maintaining amino acid homeostasis. Under amino acid limitation, Gcn2 becomes activated, subsequently increasing the levels of phosphorylated eIF2α (eIF2α-P). This leads to the increased translation of transcriptional regulators, such as Gcn4 in yeast and ATF4 in mammals, and subsequent re-programming of the cell's gene transcription profile, thereby allowing cells to cop...
Source: The Biochemical Journal - March 5, 2024 Category: Biochemistry Authors: Renuka Shanmugam Reuben Anderson Anja H Schiemann Evelyn Sattlegger Source Type: research
Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2 α phosphorylation
Biochem J. 2024 Mar 5:BCJ20220531. doi: 10.1042/BCJ20220531. Online ahead of print.ABSTRACTThe protein kinase Gcn2 and its effector protein Gcn1 are part of the General Amino Acid Control signalling (GAAC) pathway best known in yeast for its function in maintaining amino acid homeostasis. Under amino acid limitation, Gcn2 becomes activated, subsequently increasing the levels of phosphorylated eIF2α (eIF2α-P). This leads to the increased translation of transcriptional regulators, such as Gcn4 in yeast and ATF4 in mammals, and subsequent re-programming of the cell's gene transcription profile, thereby allowing cells to cop...
Source: The Biochemical Journal - March 5, 2024 Category: Biochemistry Authors: Renuka Shanmugam Reuben Anderson Anja H Schiemann Evelyn Sattlegger Source Type: research
