Sperm induce a secondary increase in ATP levels in mouse eggs that is independent of Ca2+ oscillations
Biochem J. 2023 Nov 28:BCJ20230065. doi: 10.1042/BCJ20230065. Online ahead of print.ABSTRACTEgg activation at fertilization in mouse eggs is caused by a series of cytosolic Ca2+ oscillations that are associated with an increase in ATP concentrations driven by increased mitochondrial activity. We have investigated the role of Ca2+ oscillations in these changes in ATP at fertilization by measuring the dynamics of ATP and Ca2+ in mouse eggs. An initial ATP increase started with the first Ca2+ transient at fertilization and then a secondary increase in ATP occurred about 1 hour later and this preceded a small and temporary inc...
Source: The Biochemical Journal - November 28, 2023 Category: Biochemistry Authors: Cindy Ikie-Eshalomi Elnur Aliyev Sven Hoehn Thomasz Jukowski Karl Swann Source Type: research
Leukotriene B4 receptor 1 (BLT1) does not mediate disease progression in a mouse model of liver fibrosis
Biochem J. 2023 Nov 28:BCJ20230422. doi: 10.1042/BCJ20230422. Online ahead of print.ABSTRACTMASH is a prevalent liver disease that can progress to fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and ultimately death, but there are no approved therapies. Leukotriene B4 (LTB4) is a potent pro-inflammatory chemoattractant that drives macrophage and neutrophil chemotaxis, and genetic loss or inhibition of its high affinity receptor, leukotriene B4 receptor 1 (BLT1), results in improved insulin sensitivity and decreased hepatic steatosis. To validate the therapeutic efficacy of BLT1 inhibition in an inflammatory and pro-fi...
Source: The Biochemical Journal - November 28, 2023 Category: Biochemistry Authors: Erin Coyne Yilin Nie Desiree Abdurrachim Charlene Lin Zhi Ong Yongqi Zhou Asad Abu Bakar Ali Stacey Meyers Jeff Grein Wendy Blumenschein Brendan Gongol Yang Liu Cedric Lorenz Hugelshofer Ester Carballo-Jane Saswata Talukdar Source Type: research
Sperm induce a secondary increase in ATP levels in mouse eggs that is independent of Ca2+ oscillations
Biochem J. 2023 Nov 28:BCJ20230065. doi: 10.1042/BCJ20230065. Online ahead of print.ABSTRACTEgg activation at fertilization in mouse eggs is caused by a series of cytosolic Ca2+ oscillations that are associated with an increase in ATP concentrations driven by increased mitochondrial activity. We have investigated the role of Ca2+ oscillations in these changes in ATP at fertilization by measuring the dynamics of ATP and Ca2+ in mouse eggs. An initial ATP increase started with the first Ca2+ transient at fertilization and then a secondary increase in ATP occurred about 1 hour later and this preceded a small and temporary inc...
Source: The Biochemical Journal - November 28, 2023 Category: Biochemistry Authors: Cindy Ikie-Eshalomi Elnur Aliyev Sven Hoehn Thomasz Jukowski Karl Swann Source Type: research
Leukotriene B4 receptor 1 (BLT1) does not mediate disease progression in a mouse model of liver fibrosis
Biochem J. 2023 Nov 28:BCJ20230422. doi: 10.1042/BCJ20230422. Online ahead of print.ABSTRACTMASH is a prevalent liver disease that can progress to fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and ultimately death, but there are no approved therapies. Leukotriene B4 (LTB4) is a potent pro-inflammatory chemoattractant that drives macrophage and neutrophil chemotaxis, and genetic loss or inhibition of its high affinity receptor, leukotriene B4 receptor 1 (BLT1), results in improved insulin sensitivity and decreased hepatic steatosis. To validate the therapeutic efficacy of BLT1 inhibition in an inflammatory and pro-fi...
Source: The Biochemical Journal - November 28, 2023 Category: Biochemistry Authors: Erin Coyne Yilin Nie Desiree Abdurrachim Charlene Lin Zhi Ong Yongqi Zhou Asad Abu Bakar Ali Stacey Meyers Jeff Grein Wendy Blumenschein Brendan Gongol Yang Liu Cedric Lorenz Hugelshofer Ester Carballo-Jane Saswata Talukdar Source Type: research
Sperm induce a secondary increase in ATP levels in mouse eggs that is independent of Ca2+ oscillations
Biochem J. 2023 Nov 28:BCJ20230065. doi: 10.1042/BCJ20230065. Online ahead of print.ABSTRACTEgg activation at fertilization in mouse eggs is caused by a series of cytosolic Ca2+ oscillations that are associated with an increase in ATP concentrations driven by increased mitochondrial activity. We have investigated the role of Ca2+ oscillations in these changes in ATP at fertilization by measuring the dynamics of ATP and Ca2+ in mouse eggs. An initial ATP increase started with the first Ca2+ transient at fertilization and then a secondary increase in ATP occurred about 1 hour later and this preceded a small and temporary inc...
Source: The Biochemical Journal - November 28, 2023 Category: Biochemistry Authors: Cindy Ikie-Eshalomi Elnur Aliyev Sven Hoehn Thomasz Jukowski Karl Swann Source Type: research
Plant adaptation to climate change
Biochem J. 2023 Nov 29;480(22):1865-1869. doi: 10.1042/BCJ20220580.ABSTRACTPlants are vital to human health and well-being, as well as helping to protect the environment against the negative impacts of climate change. They are an essential part of the 'One Health' strategy that seeks to balance and optimize the health of people, animals and the environment. Crucially, plants are central to nature-based solutions to climate mitigation, not least because soil carbon storage is an attractive strategy for mitigating greenhouse gas emissions and the associated climate change. Agriculture depends on genetically pure, high-qualit...
Source: The Biochemical Journal - November 23, 2023 Category: Biochemistry Authors: Christine H Foyer Ilse Kranner Source Type: research
Plant adaptation to climate change
Biochem J. 2023 Nov 29;480(22):1865-1869. doi: 10.1042/BCJ20220580.ABSTRACTPlants are vital to human health and well-being, as well as helping to protect the environment against the negative impacts of climate change. They are an essential part of the 'One Health' strategy that seeks to balance and optimize the health of people, animals and the environment. Crucially, plants are central to nature-based solutions to climate mitigation, not least because soil carbon storage is an attractive strategy for mitigating greenhouse gas emissions and the associated climate change. Agriculture depends on genetically pure, high-qualit...
Source: The Biochemical Journal - November 23, 2023 Category: Biochemistry Authors: Christine H Foyer Ilse Kranner Source Type: research
Plant adaptation to climate change
Biochem J. 2023 Nov 29;480(22):1865-1869. doi: 10.1042/BCJ20220580.ABSTRACTPlants are vital to human health and well-being, as well as helping to protect the environment against the negative impacts of climate change. They are an essential part of the 'One Health' strategy that seeks to balance and optimize the health of people, animals and the environment. Crucially, plants are central to nature-based solutions to climate mitigation, not least because soil carbon storage is an attractive strategy for mitigating greenhouse gas emissions and the associated climate change. Agriculture depends on genetically pure, high-qualit...
Source: The Biochemical Journal - November 23, 2023 Category: Biochemistry Authors: Christine H Foyer Ilse Kranner Source Type: research
Plant adaptation to climate change
Biochem J. 2023 Nov 29;480(22):1865-1869. doi: 10.1042/BCJ20220580.ABSTRACTPlants are vital to human health and well-being, as well as helping to protect the environment against the negative impacts of climate change. They are an essential part of the 'One Health' strategy that seeks to balance and optimize the health of people, animals and the environment. Crucially, plants are central to nature-based solutions to climate mitigation, not least because soil carbon storage is an attractive strategy for mitigating greenhouse gas emissions and the associated climate change. Agriculture depends on genetically pure, high-qualit...
Source: The Biochemical Journal - November 23, 2023 Category: Biochemistry Authors: Christine H Foyer Ilse Kranner Source Type: research
Enzyme function and evolution through the lens of bioinformatics
Biochem J. 2023 Nov 29;480(22):1845-1863. doi: 10.1042/BCJ20220405.ABSTRACTEnzymes have been shaped by evolution over billions of years to catalyse the chemical reactions that support life on earth. Dispersed in the literature, or organised in online databases, knowledge about enzymes can be structured in distinct dimensions, either related to their quality as biological macromolecules, such as their sequence and structure, or related to their chemical functions, such as the catalytic site, kinetics, mechanism, and overall reaction. The evolution of enzymes can only be understood when each of these dimensions is considered...
Source: The Biochemical Journal - November 22, 2023 Category: Biochemistry Authors: Antonio J M Ribeiro Ioannis G Riziotis Neera Borkakoti Janet M Thornton Source Type: research
Enzyme function and evolution through the lens of bioinformatics
Biochem J. 2023 Nov 29;480(22):1845-1863. doi: 10.1042/BCJ20220405.ABSTRACTEnzymes have been shaped by evolution over billions of years to catalyse the chemical reactions that support life on earth. Dispersed in the literature, or organised in online databases, knowledge about enzymes can be structured in distinct dimensions, either related to their quality as biological macromolecules, such as their sequence and structure, or related to their chemical functions, such as the catalytic site, kinetics, mechanism, and overall reaction. The evolution of enzymes can only be understood when each of these dimensions is considered...
Source: The Biochemical Journal - November 22, 2023 Category: Biochemistry Authors: Antonio J M Ribeiro Ioannis G Riziotis Neera Borkakoti Janet M Thornton Source Type: research
Elevated atmospheric carbon dioxide and plant immunity to fungal pathogens: do the risks outweigh the benefits?
Biochem J. 2023 Nov 29;480(22):1791-1804. doi: 10.1042/BCJ20230152.ABSTRACTAnthropogenic emissions have caused atmospheric carbon dioxide (CO2) concentrations to double since the industrial revolution. Although this could benefit plant growth from the 'CO2 fertilisation' effect, recent studies report conflicting impacts of elevated CO2 (eCO2) on plant-pathogen interactions. Fungal pathogens are the leading cause of plant disease. Since climate change has been shown to affect the distribution and virulence of these pathogens, it is important to understand how their plant hosts may also respond. This review assesses existing...
Source: The Biochemical Journal - November 17, 2023 Category: Biochemistry Authors: Freya Smith Estrella Luna Source Type: research
Elevated atmospheric carbon dioxide and plant immunity to fungal pathogens: do the risks outweigh the benefits?
Biochem J. 2023 Nov 29;480(22):1791-1804. doi: 10.1042/BCJ20230152.ABSTRACTAnthropogenic emissions have caused atmospheric carbon dioxide (CO2) concentrations to double since the industrial revolution. Although this could benefit plant growth from the 'CO2 fertilisation' effect, recent studies report conflicting impacts of elevated CO2 (eCO2) on plant-pathogen interactions. Fungal pathogens are the leading cause of plant disease. Since climate change has been shown to affect the distribution and virulence of these pathogens, it is important to understand how their plant hosts may also respond. This review assesses existing...
Source: The Biochemical Journal - November 17, 2023 Category: Biochemistry Authors: Freya Smith Estrella Luna Source Type: research
Elevated atmospheric carbon dioxide and plant immunity to fungal pathogens: do the risks outweigh the benefits?
Biochem J. 2023 Nov 29;480(22):1791-1804. doi: 10.1042/BCJ20230152.ABSTRACTAnthropogenic emissions have caused atmospheric carbon dioxide (CO2) concentrations to double since the industrial revolution. Although this could benefit plant growth from the 'CO2 fertilisation' effect, recent studies report conflicting impacts of elevated CO2 (eCO2) on plant-pathogen interactions. Fungal pathogens are the leading cause of plant disease. Since climate change has been shown to affect the distribution and virulence of these pathogens, it is important to understand how their plant hosts may also respond. This review assesses existing...
Source: The Biochemical Journal - November 17, 2023 Category: Biochemistry Authors: Freya Smith Estrella Luna Source Type: research
Interactions of mitochondrial and skeletal muscle biology in mitochondrial myopathy
Biochem J. 2023 Nov 15;480(21):1767-1789. doi: 10.1042/BCJ20220233.ABSTRACTMitochondrial dysfunction in skeletal muscle fibres occurs with both healthy aging and a range of neuromuscular diseases. The impact of mitochondrial dysfunction in skeletal muscle and the way muscle fibres adapt to this dysfunction is important to understand disease mechanisms and to develop therapeutic interventions. Furthermore, interactions between mitochondrial dysfunction and skeletal muscle biology, in mitochondrial myopathy, likely have important implications for normal muscle function and physiology. In this review, we will try to give an o...
Source: The Biochemical Journal - November 15, 2023 Category: Biochemistry Authors: Valeria Di Leo Tiago M Bernardino Gomes Amy E Vincent Source Type: research
