PPAR < em > β < /em > / < em > δ < /em > Agonism with GW501516 Increases Myotube PGC-1 < em > α < /em > Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression
CONCLUSION: These data confirm the ability of GW to increase muscle PGC-1α content and decrease BCAA media content without affecting BCAA catabolic enzymes/transporter. These findings suggest heightened BCAA uptake (and possibly metabolism) may occur without substantial changes in the protein levels of related cell machinery.PMID:37325367 | PMC:PMC10264138 | DOI:10.1155/2023/4779199 (Source: PPAR Research)
Source: PPAR Research - June 16, 2023 Category: Genetics & Stem Cells Authors: Caroline N Rivera Jason S Hinkle Rachel M Watne Trent C Macgowan Andrew J Wommack Roger A Vaughan Source Type: research
Development and Validation of the Promising PPAR Signaling Pathway-Based Prognostic Prediction Model in Uterine Cervical Cancer
PPAR Res. 2023 May 31;2023:4962460. doi: 10.1155/2023/4962460. eCollection 2023.ABSTRACTA ligand-activated transcription factor, peroxisome proliferator-activated receptor (PPAR) regulates fatty acid uptake and transport. In several studies, upregulation of PPAR expression/activity by cancer cells has been associated with cancer progression. Worldwide, cancer of the cervix ranks fourth among women's cancers. Angiogenesis inhibitors have improved treatment for recurrent and advanced cervical cancer since their introduction 5 years ago. In spite of that, the median overall survival rate for advanced cervical cancer is 16.8 m...
Source: PPAR Research - June 9, 2023 Category: Genetics & Stem Cells Authors: Yan Zhang Xing Li Jun Zhang Lin Mao Zou Wen Mingliang Cao Xuefeng Mu Source Type: research
Comprehensive Analysis Identifies the PPAR-Targeted Genes Associated with Ovarian Cancer Prognosis and Tumor Microenvironment
CONCLUSIONS: Our study identified a prognosis signature that could effectively indicates patients survival. Meanwhile, our study can provide the direction for future studies focused on the PPARs in OC.PMID:37213709 | PMC:PMC10195182 | DOI:10.1155/2023/6637414 (Source: PPAR Research)
Source: PPAR Research - May 22, 2023 Category: Genetics & Stem Cells Authors: Xiao-Fei Leng Gao-Fa Wang Hao Yin Feng Wei Kang-Kang Zeng Yi-Qun Zhang Source Type: research
