Significance of PPARA as a Treatment Target for Chronic Lymphocytic Leukemia
In this study, we analyzed DNA next-generation sequencing (NGS) data and clinical information from 86 CLL patients to identify gene markers related to treatment-free survival (TFS) length. We then constructed a genetic network that includes CLL promoters, treatment targets, and TFS-related marker genes. To assess the significance of PPARA within the network, we utilized degree centrality (DC) and pathway enrichment score (EScore). Clinical and NGS data revealed 10 TFS length-related gene markers, including RPS15, FOXO1, FBXW7, KMT2A, NOTCH1, GNA12, EGR2, GNA13, KDM6A, and ATM. Through literature data mining, 83 genes were ...
Source: PPAR Research - July 5, 2023 Category: Genetics & Stem Cells Authors: Xixi Xiang Fu Li Sha Zhou Yunjing Zeng Xiaojuan Deng Hongyang Zhang Jiali Li Hongyun Liu Jun Rao Lei Gao Cheng Zhang Qin Wen Li Gao Xi Zhang Source Type: research
