Buspirone Induces Weight Loss and Normalization of Blood Pressure via the Stimulation of PPAR < em > δ < /em > Dependent Energy Producing Pathway in Spontaneously Hypertensive Rats
CONCLUSION: Buspirone may induce the losses of body weight and abdominal fat weight through the activation of PPARδ dependent catabolic metabolism producing energy, and eventually, the ameliorated lipid metabolism could normalize high blood pressure.PMID:37168052 | PMC:PMC10164918 | DOI:10.1155/2023/7550164 (Source: PPAR Research)
Source: PPAR Research - May 11, 2023 Category: Genetics & Stem Cells Authors: Yong-Jik Lee Hyun-Min Kim Yoo-Na Jang Yoon-Mi Han Hong Seog Seo Tae Woo Jung Ji Hoon Jeong Hyun Jung Lee Kyung Oh Jung Source Type: research
Peptide Helix-Y < sup > 12 < /sup > as Potential Effector for Peroxisome Proliferator-Activated Receptors
This study aimed to evaluate some components of the atheroprotective and hepatoprotective HB-ATV-8 nanoparticles [the amphipathic peptide Helix-Y12, thermozeaxanthin, thermozeaxanthin-13, thermozeaxanthin-15, and a set of glycolipids], as possible ligands of PPARs through blind molecular docking. According to the change in free energy upon protein-ligand binding, ∆G b, thermozeaxanthins show a more favorable interaction with PPARs, followed by Helix-Y12. Moreover, Helix-Y12 interacts with most parts of the Y-shaped ligand-binding domain (LBD), surrounding helix 3 of PPARs, and reaching helix 12 of PPARα and PPARγ. As p...
Source: PPAR Research - April 25, 2023 Category: Genetics & Stem Cells Authors: Mauricio Carrillo-Tripp Yair Reyes Blanca Delgado-Coello Jaime Mas-Oliva Roxana Guti érrez-Vidal Source Type: research
