PPAR < em > β < /em > / < em > δ < /em > Agonism with GW501516 Increases Myotube PGC-1 < em > α < /em > Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression

CONCLUSION: These data confirm the ability of GW to increase muscle PGC-1α content and decrease BCAA media content without affecting BCAA catabolic enzymes/transporter. These findings suggest heightened BCAA uptake (and possibly metabolism) may occur without substantial changes in the protein levels of related cell machinery.PMID:37325367 | PMC:PMC10264138 | DOI:10.1155/2023/4779199

Source: PPAR Research - June 16, 2023 Category: Genetics & Stem Cells Authors: Caroline N Rivera Jason S Hinkle Rachel M Watne Trent C Macgowan Andrew J Wommack Roger A Vaughan Source Type: research