3D Echocardiographic and Computed Tomographic Angiography Guidance for Percutaneous Closure of a Type II (Intermediate) Aortopulmonary Window
This report highlights the importance of a multimodality imaging approach to interventional procedures. (Source: Pediatric Cardiology)
Source: Pediatric Cardiology - March 23, 2024 Category: Cardiology Source Type: research
Impact of Underweight, Overweight, and Obesity on Health-Related Quality of Life in Children with Tetralogy of Fallot Variants
AbstractTraditional cardiovascular risk factors put patients with congenital heart disease (CHD) at increased risk for cardiovascular morbidity and mortality. The aim of this study was to evaluate whether body mass index (BMI) is associated with health-related quality of life (HRQoL) in patients with variants of Tetralogy of Fallot (TOF). Patients and parents of children with variants of TOF –CHD were asked to fill out the PedsQL 4.0 questionnaire and provide weight and length. Patients were categorized into low, normal, and high BMI percentiles. Other demographic data were obtained from the Swedish national registry for...
Source: Pediatric Cardiology - March 20, 2024 Category: Cardiology Source Type: research
Wireless Pulmonary Artery Pressure Monitor Implantation in a Patient with Duchenne Muscular Dystrophy
AbstractAssessing heart failure progression in patients with Duchenne Muscular Dystrophy (DMD) is challenging given the multi-system nature of disease. Herein we describe the first case use of an implantable pulmonary artery pressure monitor and describe the potential clinical utility of this approach in patients with DMD. (Source: Pediatric Cardiology)
Source: Pediatric Cardiology - March 19, 2024 Category: Cardiology Source Type: research
Author Response to Letter to the Editor Re: “Left Ventricular Dysfunction Following Repair of Ventricular Septal Defects in Infants”
(Source: Pediatric Cardiology)
Source: Pediatric Cardiology - March 18, 2024 Category: Cardiology Source Type: research
Risk Factors and Outcomes Associated with Gaps in Care in Children with Congenital Heart Disease
AbstractAdults with congenital heart disease (CHD) benefit from cardiology follow-up at recommended intervals of ≤ 2 years. However, benefit for children is less clear given limited studies and unclear current guidelines. We hypothesize there are identifiable risks for gaps in cardiology follow-up in children with CHD and that gaps in follow-up are associated with differences in healthcare utilization. Our cohort included children < 10 years old with CHD and a healthcare encounter from 2008 to 2013 at one of four North Carolina (NC) hospitals. We assessed associations between cardiology follow-up and demog...
Source: Pediatric Cardiology - March 14, 2024 Category: Cardiology Source Type: research
Analysis of Cytokine Profiles in Pediatric Myocarditis Multicenter Study
This study aims to evaluate the cytokine profiles of acute and fulminant myocarditis in children. Pediatric patients diagnosed with myocarditis were included in the study. Cytokine levels were measured using a multiplexed fluorescent bead-based immunoassay. Statistical analysis was performed to compare patient characteristics and cytokine levels between FM, AM, and healthy control (HC) groups. Principal component analysis (PCA) was applied to cytokine groups that were independent among the FM, AM, and HC groups. The study included 22 patients with FM and 14 with AM patients. We identified four cytokines that were significa...
Source: Pediatric Cardiology - March 13, 2024 Category: Cardiology Source Type: research
Clinical Outcomes and Echocardiographic Predictors of Reintervention After Interrupted Aortic Arch Repair
AbstractLeft ventricular outflow tract obstruction (LVOTO) remains a significant complication after primary repair of interrupted aortic arch with ventricular septal defect (IAA-VSD). Clinical and echocardiographic predictors for LVOTO reoperation are controversial and procedures to prophylactically prevent future LVOTO are not reliable. However, it is important to identify the patients at risk for future LVOTO intervention after repair of IAA-VSD. Patients who underwent single-stage IAA-VSD repair at our center 2006 –2021 were retrospectively reviewed, excluding patients with associated cardiac lesions. Two-dimensional ...
Source: Pediatric Cardiology - March 13, 2024 Category: Cardiology Source Type: research
Differential Regulation of Immune-Related Genes in the Developing Heart
In conclusion, differences exist between the gene expression profiles of RV versus LV with the expression of immune-related genes being significantly different between these two chambers. The pathogenesis of HLHS may involve alterations i n the expression of chromatin and muscle gene organization as well as upregulation of the IL-17 response pathway. (Source: Pediatric Cardiology)
Source: Pediatric Cardiology - March 13, 2024 Category: Cardiology Source Type: research
Cardiac Rhabdomyomas Presenting with Critical Cardiac Obstruction in Neonates and Infants: Treatment Strategies and Outcome, A Single-Center Experience
We present the outcomes of neonates and an infant who received treatment for symptomatic rhabdomyomas at a tertiary cardiology center. Medical records were reviewed to obtain clinical, demographic, and outcome data. Six patients received interventions for symptomatic rhabdomyomas, median age at presentation was 1 day old (range from 1 to 121 days old), and 67% of the patients had a pathogenic mutation in TSC gene. One patient underwent surgical resection of solitary tumor at right ventricular outflow tract (RVOT) successfully. In the four patients with left ventricular outflow tract (LVOT) obstruction, two patients receive...
Source: Pediatric Cardiology - March 13, 2024 Category: Cardiology Source Type: research
Morphology, Clinical Associations, and Pathologic Follow-up of Quadricuspid Aortic Valves in Children
In conclusion, QAV is a rare congenital anomaly and about half of the cases are found in hearts that are otherwise structurally normal. A relatively high prevalence is seen in patients with TOF, pulmonary stenosis, skeletal deformities, and genetic syndromes. Meticulous evaluation of aortic valve morphology should be conducted on echocardiograms performed for these indications. (Source: Pediatric Cardiology)
Source: Pediatric Cardiology - March 13, 2024 Category: Cardiology Source Type: research
Socioeconomic Influences on Outcomes Following Congenital Heart Disease Surgery
We examined the relationship between community-level material deprivation on mortality, readmission, and length of stay (LOS) for children undergoing surgery for CHD. We performed a retrospective cohort study of patients who underwent cardiac surgery at our institution from 2015 to 2018. A community-level deprivation index (DI), a marker of community material deprivation, was generated to contextualize the lived experience of children with CHD. Generalized mixed-effects models were used to assess links between the DI and outcomes of mortality, readmission, and LOS following cardiac surgery. The DI and components were scale...
Source: Pediatric Cardiology - March 12, 2024 Category: Cardiology Source Type: research
Variations in the Evaluation and Management of Vascular Rings: A Survey of American Clinicians
This study identified significant variation between clinicians regarding the evaluation and management of vascular rings. Further research or expert opinions may help to standardize practice, saving costs and improving the quality of care for affected patients. (Source: Pediatric Cardiology)
Source: Pediatric Cardiology - March 11, 2024 Category: Cardiology Source Type: research
Obesity Predisposes Anthracycline-Treated Survivors of Childhood and Adolescent Cancers to Subclinical Cardiac Dysfunction
AbstractAnthracyclines are effective chemotherapeutics used in approximately 60% of pediatric cancer cases but have a well-documented risk of cardiotoxicity. Existing cardiotoxicity risk calculators do not include cardiovascular risk factors present at the time of diagnosis. The goal of this study is to leverage the advanced sensitivity of strain echocardiography to identify pre-existing risk factors for early subclinical cardiac dysfunction among anthracycline-exposed pediatric patients. We identified 115 pediatric patients with cancer who were treated with an anthracycline between 2013 and 2019. Peak longitudinal left ve...
Source: Pediatric Cardiology - March 8, 2024 Category: Cardiology Source Type: research
Postoperative Atrioventricular Block in Pediatric Patients: Impact of Congenital Cardiac Malformations and Medications
AbstractPostoperative atrioventricular block may occur after pediatric cardiac surgery. A small proportion of those who develop atrioventricular block will require pacemaker placement. The primary aim of this study was to determine factors associated with postoperative atrioventricular block. Secondary aims included determining factors associated with pacemaker placement in those with atrioventricular block. Data from the PHIS data were utilized to identify patients under 18 years of age who underwent cardiac surgery. Those who did and did not develop atrioventricular block. Univariable analyses and regression analyses wer...
Source: Pediatric Cardiology - March 1, 2024 Category: Cardiology Source Type: research
Is There a Role for Alcohol Septal Ablation in Young Patients with Medically Refractory Hypertrophic Obstructive Cardiomyopathy?
AbstractSurgical myectomy is recommended for symptomatic hypertrophic obstructive cardiomyopathy (HOCM) after optimal pharmacological therapy. Percutaneous transluminal septal myocardial ablation (PTSMA) is reserved for high-risk adults. Symptomatic patients below 25 years underwent either surgery or PTSMA after heart-team discussion and informed consent. Echocardiography assessed gradients in surgical group. PTSMA group underwent invasive transseptal hemodynamic assessment, selective coronary angiography and super-selective cannulation of septal perforators u sing microcatheters. Contrast echocardiography through the mi...
Source: Pediatric Cardiology - February 28, 2024 Category: Cardiology Source Type: research
