Identification of Hub Genes and Potential Molecular Pathogenesis in Substantia Nigra in Parkinson's Disease via Bioinformatics Analysis
Parkinsons Dis. 2023 Apr 14;2023:6755569. doi: 10.1155/2023/6755569. eCollection 2023.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease, with significant socioeconomic burdens. One of the crucial pathological features of PD is the loss of dopaminergic neurons in the substantia nigra (SN). However, the exact pathogenesis remains unknown. Moreover, therapies to prevent neurodegenerative progress are still being explored. We performed bioinformatics analysis to identify candidate genes and molecular pathogenesis in the SN of patients with PD. We analyzed the expression profiles, GSE49036 and...
Source: Parkinsons Disease - April 24, 2023 Category: Neurology Authors: Yunan Zhou Zhihui Li Chunling Chi Chunmei Li Meimei Yang Bin Liu Source Type: research
