Transfection of the BDNF Gene in the Surviving Dopamine Neurons in Conjunction with Continuous Administration of Pramipexole Restores Normal Motor Behavior in a Bilateral Rat Model of Parkinson's Disease
Parkinsons Dis. 2024 Feb 21;2024:3885451. doi: 10.1155/2024/3885451. eCollection 2024.ABSTRACTIn Parkinson's disease (PD), progressive degeneration of nigrostriatal innervation leads to atrophy and loss of dendritic spines of striatal medium spiny neurons (MSNs). The loss disrupts corticostriatal transmission, impairs motor behavior, and produces nonmotor symptoms. Nigral neurons express brain-derived neurotropic factor (BDNF) and dopamine D3 receptors, both protecting the dopamine neurons and the spines of MSNs. To restore motor and nonmotor symptoms to normality, we assessed a combined therapy in a bilateral rat Parkinso...
Source: Parkinsons Disease - February 29, 2024 Category: Neurology Authors: Alina Ben ítez-Castañeda Ver ónica Anaya-Martínez Armando de Jes ús Espadas-Alvarez Ana Luisa Gutierrez-V áldez Luis Fernando Razgado-Hern ández Patricia Emmanuelle Reyna-Velazquez Liz Quintero-Macias Daniel Mart ínez-Fong Benjam ín Florán-Gardu Source Type: research
Improvement by Medication Less than Expected in Parkinson's Disease: Blinded Evaluation of Levodopa Response
CONCLUSIONS: We showed an acute effect of levodopa using LDCT that was around 30% improvement. While it lends support to the use of this limit in the MDS diagnostic criteria, an acute effect of less than 30% should be considered acceptable in some patients. Our study highlights a discrepancy in the objective measure of medicine effect on motor symptoms and the patient's subjective evaluation.PMID:38419645 | PMC:PMC10901577 | DOI:10.1155/2024/2649578 (Source: Parkinsons Disease)
Source: Parkinsons Disease - February 29, 2024 Category: Neurology Authors: Mette Niemann Johansen Anna Handberg Mohamed El Haddouchi Josefine Grundtvig Steen Rusborg Jensen Lisette Salvesen Annemette L økkegaard Source Type: research
Preoperative Attention/Memory Problem Affects the Quality of Life of Parkinson's Disease Patients after Deep Brain Stimulation: A Cohort Study
CONCLUSION: Deep brain stimulation (DBS) led to an improvement in the patients' nonmotor symptoms (NMS) at the 1-year follow-up, along with a correlation observed between NMS and the patients' quality of life (QoL). Notably, the severity of preoperative attention/memory problems emerged as the most significant predictor of NMS influencing the QoL outcome after STN-DBS at the 1-year follow-up.PMID:38356939 | PMC:PMC10866634 | DOI:10.1155/2024/3651705 (Source: Parkinsons Disease)
Source: Parkinsons Disease - February 15, 2024 Category: Neurology Authors: Ying Gao Jue Wang Linbin Wang Dianyou Li Bomin Sun Xian Qiu Source Type: research
A Systematic Review and Meta-Analysis of the Efficacy and Safety of Rasagiline or Pramipexole in the Treatment of Early Parkinson's Disease
CONCLUSION: Applying a Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach to summarize the evidence, we found moderate confidence in the body of evidence for the efficacy of rasagiline or pramipexole in early PD, suggesting further well-designed, multicenter comparative RCTs remain needed.PMID:38264500 | PMC:PMC10805557 | DOI:10.1155/2024/8448584 (Source: Parkinsons Disease)
Source: Parkinsons Disease - January 24, 2024 Category: Neurology Authors: Pauli Sepp änen Markus M Forsberg Miia Tiihonen Heikki Laitinen Selena Beal David C Dorman Source Type: research
Alprazolam Reduces Freezing of Gait (FOG) and Improves FOG-Related Gait Deficiencies
Parkinsons Dis. 2024 Jan 9;2024:3447009. doi: 10.1155/2024/3447009. eCollection 2024.ABSTRACTBACKGROUND: Freezing of gait (FOG) is an intractable motor symptom in Parkinson's disease (PD) that increases fall risk and impairs the quality of life. FOG has been associated with anxiety, with experimental support for the notion that anxiety itself provokes FOG. We investigated the effect of acute anxiety reduction via alprazolam on FOG in PD.METHODS: In ten patients with PD, FOG, and normal cognition, we administered 0.25 mg alprazolam in one session and placebo in another, in counterbalanced order. At each session, on separate...
Source: Parkinsons Disease - January 18, 2024 Category: Neurology Authors: Abdullah Al Jaja T éa Sue Margaret Prenger Ken N Seergobin Jessica A Grahn Penny A MacDonald Source Type: research
Single-Cell Analyses Reveal Necroptosis's Potential Role in Neuron Degeneration and Show Enhanced Neuron-Immune Cell Interaction in Parkinson's Disease Progression
Parkinsons Dis. 2023 Dec 19;2023:5057778. doi: 10.1155/2023/5057778. eCollection 2023.ABSTRACTParkinson's disease (PD) is a common neuron degenerative disease among the old, characterized by uncontrollable movements and an impaired posture. Although widely investigated on its pathology and treatment, the disease remains incompletely understood. Single-cell RNA sequencing (scRNA-seq) has been applied to the area of PD, providing valuable data for related research. However, few works have taken deeper insights into the causes of neuron death and cell-cell interaction between the cell types in the brain. Our bioinformatics an...
Source: Parkinsons Disease - December 27, 2023 Category: Neurology Authors: Xiaomei Zeng Zhifen Han Kehan Chen Peng Zeng Yidan Tang Lijuan Li Source Type: research
