The Neuroprotective Effect of Isotetrandrine on Parkinson's Disease via Anti-Inflammation and Antiapoptosis < em > In Vitro < /em > and < em > In Vivo < /em >
Parkinsons Dis. 2023 Oct 10;2023:8444153. doi: 10.1155/2023/8444153. eCollection 2023.ABSTRACTParkinson's disease (PD) is one of the most influential diseases in the world, and the current medication only can relieve the clinical symptoms but not slow the progression of PD. Therefore, we intend to examine the neuroprotective activity of plant-derived compound isotetrandrine (ITD) in vitro and in vivo. In vitro, cells were cotreated with ITD and LPS to detect the inflammatory-related protein and mRNA. In vivo, zebrafish were pretreated with ITD and inhibitors prior to 6-OHDA treatment. Then, the behavior was monitored at 5 ...
Source: Parkinsons Disease - October 19, 2023 Category: Neurology Authors: Ching-Hu Wu Kun-Ling Lin Cheng-Yu Long Chien-Wei Feng Source Type: research
Compliance with National and International Guidelines in the Treatment of Nonmotor Symptoms in Late-Stage Parkinson's Disease
CONCLUSIONS: The present analyses suggest a need for clinicians to further screen for and treat NMS. Optimizing treatment of NMS according to the national and international treatment guidelines may improve symptomatology and enhance quality of life in late-stage PD.PMID:37854895 | PMC:PMC10581854 | DOI:10.1155/2023/6667339 (Source: Parkinsons Disease)
Source: Parkinsons Disease - October 19, 2023 Category: Neurology Authors: Kristina Rosqvist Per Odin Source Type: research
The Neuroprotective Effect of Isotetrandrine on Parkinson's Disease via Anti-Inflammation and Antiapoptosis < em > In Vitro < /em > and < em > In Vivo < /em >
Parkinsons Dis. 2023 Oct 10;2023:8444153. doi: 10.1155/2023/8444153. eCollection 2023.ABSTRACTParkinson's disease (PD) is one of the most influential diseases in the world, and the current medication only can relieve the clinical symptoms but not slow the progression of PD. Therefore, we intend to examine the neuroprotective activity of plant-derived compound isotetrandrine (ITD) in vitro and in vivo. In vitro, cells were cotreated with ITD and LPS to detect the inflammatory-related protein and mRNA. In vivo, zebrafish were pretreated with ITD and inhibitors prior to 6-OHDA treatment. Then, the behavior was monitored at 5 ...
Source: Parkinsons Disease - October 19, 2023 Category: Neurology Authors: Ching-Hu Wu Kun-Ling Lin Cheng-Yu Long Chien-Wei Feng Source Type: research
Compliance with National and International Guidelines in the Treatment of Nonmotor Symptoms in Late-Stage Parkinson's Disease
CONCLUSIONS: The present analyses suggest a need for clinicians to further screen for and treat NMS. Optimizing treatment of NMS according to the national and international treatment guidelines may improve symptomatology and enhance quality of life in late-stage PD.PMID:37854895 | PMC:PMC10581854 | DOI:10.1155/2023/6667339 (Source: Parkinsons Disease)
Source: Parkinsons Disease - October 19, 2023 Category: Neurology Authors: Kristina Rosqvist Per Odin Source Type: research
The Neuroprotective Effect of Isotetrandrine on Parkinson's Disease via Anti-Inflammation and Antiapoptosis < em > In Vitro < /em > and < em > In Vivo < /em >
Parkinsons Dis. 2023 Oct 10;2023:8444153. doi: 10.1155/2023/8444153. eCollection 2023.ABSTRACTParkinson's disease (PD) is one of the most influential diseases in the world, and the current medication only can relieve the clinical symptoms but not slow the progression of PD. Therefore, we intend to examine the neuroprotective activity of plant-derived compound isotetrandrine (ITD) in vitro and in vivo. In vitro, cells were cotreated with ITD and LPS to detect the inflammatory-related protein and mRNA. In vivo, zebrafish were pretreated with ITD and inhibitors prior to 6-OHDA treatment. Then, the behavior was monitored at 5 ...
Source: Parkinsons Disease - October 19, 2023 Category: Neurology Authors: Ching-Hu Wu Kun-Ling Lin Cheng-Yu Long Chien-Wei Feng Source Type: research
Compliance with National and International Guidelines in the Treatment of Nonmotor Symptoms in Late-Stage Parkinson's Disease
CONCLUSIONS: The present analyses suggest a need for clinicians to further screen for and treat NMS. Optimizing treatment of NMS according to the national and international treatment guidelines may improve symptomatology and enhance quality of life in late-stage PD.PMID:37854895 | PMC:PMC10581854 | DOI:10.1155/2023/6667339 (Source: Parkinsons Disease)
Source: Parkinsons Disease - October 19, 2023 Category: Neurology Authors: Kristina Rosqvist Per Odin Source Type: research
The Neuroprotective Effect of Isotetrandrine on Parkinson's Disease via Anti-Inflammation and Antiapoptosis < em > In Vitro < /em > and < em > In Vivo < /em >
Parkinsons Dis. 2023 Oct 10;2023:8444153. doi: 10.1155/2023/8444153. eCollection 2023.ABSTRACTParkinson's disease (PD) is one of the most influential diseases in the world, and the current medication only can relieve the clinical symptoms but not slow the progression of PD. Therefore, we intend to examine the neuroprotective activity of plant-derived compound isotetrandrine (ITD) in vitro and in vivo. In vitro, cells were cotreated with ITD and LPS to detect the inflammatory-related protein and mRNA. In vivo, zebrafish were pretreated with ITD and inhibitors prior to 6-OHDA treatment. Then, the behavior was monitored at 5 ...
Source: Parkinsons Disease - October 19, 2023 Category: Neurology Authors: Ching-Hu Wu Kun-Ling Lin Cheng-Yu Long Chien-Wei Feng Source Type: research
Compliance with National and International Guidelines in the Treatment of Nonmotor Symptoms in Late-Stage Parkinson's Disease
CONCLUSIONS: The present analyses suggest a need for clinicians to further screen for and treat NMS. Optimizing treatment of NMS according to the national and international treatment guidelines may improve symptomatology and enhance quality of life in late-stage PD.PMID:37854895 | PMC:PMC10581854 | DOI:10.1155/2023/6667339 (Source: Parkinsons Disease)
Source: Parkinsons Disease - October 19, 2023 Category: Neurology Authors: Kristina Rosqvist Per Odin Source Type: research
Levodopa Prescription Patterns in Patients with Advanced Parkinson's Disease: A Japanese Database Analysis
This study suggests that many Japanese patients with advanced PD could receive more intensive treatment with higher doses of levodopa.PMID:37799489 | PMC:PMC10550461 | DOI:10.1155/2023/9404207 (Source: Parkinsons Disease)
Source: Parkinsons Disease - October 6, 2023 Category: Neurology Authors: Atsushi Takeda Toru Baba Jun Watanabe Masahiko Nakayama Hiroyuki Hozawa Miwako Ishido Source Type: research
