A Dual GLP-1/GIP Receptor Agonist Is More Effective than Liraglutide in the A53T Mouse Model of Parkinson's Disease
Parkinsons Dis. 2023 Sep 25;2023:7427136. doi: 10.1155/2023/7427136. eCollection 2023.ABSTRACTParkinson's disease (PD) is a complex syndrome with many elements, such as chronic inflammation, oxidative stress, mitochondrial dysfunction, loss of dopaminergic neurons, build-up of alpha-synuclein (α-syn) in cells, and energy depletion in neurons, that drive the disease. We and others have shown that treatment with mimetics of the growth factor glucagon-like peptide 1 (GLP-1) can normalize energy utilization, neuronal survival, and dopamine levels and reduce inflammation. Liraglutide is a GLP-1 analogue that recently showed pr...
Source: Parkinsons Disease - October 4, 2023 Category: Neurology Authors: Zijuan Zhang Ming Shi Zhengmin Li Yuan Ling Luke Zhai Ye Yuan He Ma Li Hao Zhonghua Li Zhenqiang Zhang Christian H ölscher Source Type: research
Mercury and Parkinson's Disease: Promising Leads, but Research Is Needed
Parkinsons Dis. 2023 Sep 16;2023:4709322. doi: 10.1155/2023/4709322. eCollection 2023.ABSTRACTEnvironmental toxicants are thought to play a major role in the pathogenesis of Parkinson's disease. In reviewing the literature on heavy metals known to be toxicants, we noted several recent studies on mercury suggesting a possible role in the etiology of some cases of this disease. We therefore undertook a review of this association, focusing especially on peer-reviewed articles to avoid the bias inherent in much of the literature regarding mercury. For most people, our contemporary exposure to mercury comes from dental amalgam ...
Source: Parkinsons Disease - September 25, 2023 Category: Neurology Authors: E Fuller Torrey Wendy Simmons Source Type: research
Qualitative Analysis of Attitudes, Knowledge, and Interest in Research of People with Parkinson's Disease and Their Care Partners Receiving Accessible Research Education
CONCLUSIONS: While some findings aligned with weekly module topics, others, such as stated learning preferences and knowledge acquisition of older adults in an educational program, were unexpected. TeleDREAMS may increase interest in community engagement, research participation, and advocacy roles in marginalized and underrepresented participants.PMID:37727499 | PMC:PMC10506878 | DOI:10.1155/2023/5519646 (Source: Parkinsons Disease)
Source: Parkinsons Disease - September 20, 2023 Category: Neurology Authors: Maria E Ramos Suraj Pothineni Liang Ni Allison A Bay Todd Prusin Madeleine E Hackney Source Type: research
