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Genome Sequencing and Apoptotic Markers to Assess Treatment Response of Lacrimal Gland Adenoid Cystic Carcinoma to Intra-Arterial Cytoreductive Chemotherapy
We report the case of a 30-year-old male with lacrimal gland adenoid cystic carcinoma treated with neoadjuvant intra-arterial chemotherapy through the internal carotid artery, followed by orbital exenteration and chemoradiation. Treatment response was evaluated using a novel combination of pre- and posttreatment genome sequencing coupled with immunohistochemical evaluation, which showed diffuse tumor apoptosis. A posttreatment decrease in variant allele frequency of the NOTCH1 mutation, and robust tumor cytoreduction on imaging, supports exploration of NOTCH1 analysis as a potential marker of cisplatin sensitivity. The use...
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Case Reports Source Type: research

Rifle Blast Exacerbating Hearing Loss in a Patient Treated With Teprotumumab for Thyroid Eye Disease
Teprotumumab is a promising new immunomodulatory therapy for thyroid eye disease. One unique adverse effect observed in clinical trials was hearing impairment; however, all adverse auditory effects in prior clinical trials resolved spontaneously after completion of teprotumumab therapy. The authors present a case of a patient on teprotumumab for thyroid eye disease who experienced sustained hearing loss secondary to shooting a rifle without ear protection. In this case, it is suspected the teprotumumab infusions resulted in increased susceptibility of the inner ear hair cells to noise-induced trauma secondary to IGF-IR inh...
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Case Reports Source Type: research

Pediatric Subcutaneous Panniculitis-like T-cell Lymphoma of the Orbit
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare and distinct subtype of peripheral T-cell lymphoma, representing (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Case Reports Source Type: research

Congenital Eyelid Imbrication and Floppy Eyelid Syndrome in a Patient With Cat Eye Syndrome
A newborn male with cat eye syndrome presented with progressively worsening bilateral upper eyelid imbrication, floppy eyelids, and ptosis. Despite conservative management, he remained unable to open his eyelids. Surgical correction was planned to prevent bilateral sensory deprivation amblyopia and was delayed until 5 months of age due to systemic health concerns. Bilateral full-thickness wedge excision and frontalis suspension with silicone rods in a double rhomboid fashion was performed. Postoperatively, the patient demonstrated spontaneous eyelid opening, resolution of spastic eversion of the upper eyelids, and adequate...
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Case Reports Source Type: research

Oculoplastic Abstracts
No abstract available (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Abstracts Source Type: research

Aesthetic Abstracts
No abstract available (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Abstracts Source Type: research

Effect of Timing of Intravenous Ketorolac Administration on Pain in Orbitotomy Surgery: Erratum
No abstract available (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Erratum Source Type: research

Primary Low-grade Myofibroblastic Sarcoma of the Orbit
No abstract available (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply Re: “A New Surgical Technique for Postoperative Trachomatous Trichiasis”
No abstract available (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Re: “A New Surgical Technique for Postoperative Trachomatous Trichiasis”
No abstract available (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply Re: “Clinical Outcomes of IgG4-Related Ophthalmic Disease and Idiopathic Sclerosing Orbital Inflammation”
No abstract available (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Re: “Clinical Outcomes of IgG4-Related Ophthalmic Disease and Idiopathic Sclerosing Orbital Inflammation”
No abstract available (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Reply Re: “Direct Injection of 5-Fluorouracil Improves Outcomes in Cicatrizing Conjunctival Disorders Secondary to Systemic Disease”
No abstract available (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Re: “Direct Injection of 5-Fluorouracil Improves Outcomes in Cicatrizing Conjunctival Disorders Secondary to Systemic Disease”
No abstract available (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Techniques in Corneal Neurotization
No abstract available (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2022 Category: Opthalmology Tags: Book Review Source Type: research