A Pilot Study of High-Definition Transcranial Direct Current Stimulation in Refractory Status Epilepticus: The SURESTEP Trial
AbstractRefractory status epilepticus (RSE) is a life-threatening emergency with high mortality and poor functional outcomes in survivors. Treatment is typically limited to intravenous anesthetic infusions and multiple anti-seizure medications. While ongoing seizures can cause permanent neurological damage, medical therapies also pose severe and life-threatening side effects. We tested the feasibility of using high-definition transcranial direct current stimulation (hd-tDCS) in the treatment of RSE. We conducted 20-min hd-tDCS sessions at an outward field orientation, intensity of 2-mA, 4 + 1 channels, and customized ...
Source: Neurotherapeutics - November 2, 2022 Category: Neurology Source Type: research
Correction to: ASENT 2022 Annual Meeting
(Source: Neurotherapeutics)
Source: Neurotherapeutics - November 2, 2022 Category: Neurology Source Type: research
Early Treatment with Metformin Improves Neurological Outcomes in Lafora Disease
AbstractLafora disease is a fatal form of progressive myoclonic epilepsy caused by mutations in theEPM2A orNHLRC1/EPM2B genes that usually appears during adolescence. TheEpm2a−/− andEpm2b−/− knock-out mouse models of the disease develop behavioral and neurological alterations similar to those observed in patients. The aim of this work is to analyze whether early treatment with metformin (from conception to adulthood) ameliorates the formation of Lafora bodies and improves the behavioral and neurological outcomes observed with late treatment (during 2 months at 10 months of age). We also evaluated the benefits of...
Source: Neurotherapeutics - October 27, 2022 Category: Neurology Source Type: research
Clinical and Translational Advances in Glioma Immunotherapy
AbstractGliomas are highly treatment refractory against immune checkpoint blockade, an immunotherapeutic modality that revolutionized therapy for many tumors. At the same time, technological innovation has dramatically accelerated the development of immunotherapeutic approaches such as personalized tumor-specific vaccine production, dendritic cell vaccine manufacture, patient-individual target selection and chimeric antigen receptor, and T cell receptor T cell manufacture. Here we review recent clinical and translational advances in glioma immunotherapy with a focus on targets and their cognate immune receptor derivates as...
Source: Neurotherapeutics - October 27, 2022 Category: Neurology Source Type: research
Commentary on: A Network Approach to Understanding the Effects of Focused Ultrasound for Essential Tremor: Insights into Pathophysiology, Treatment, and Imaging Biomarkers
(Source: Neurotherapeutics)
Source: Neurotherapeutics - October 27, 2022 Category: Neurology Source Type: research
Early Treatment with Metformin Improves Neurological Outcomes in Lafora Disease
AbstractLafora disease is a fatal form of progressive myoclonic epilepsy caused by mutations in theEPM2A orNHLRC1/EPM2B genes that usually appears during adolescence. TheEpm2a−/− andEpm2b−/− knock-out mouse models of the disease develop behavioral and neurological alterations similar to those observed in patients. The aim of this work is to analyze whether early treatment with metformin (from conception to adulthood) ameliorates the formation of Lafora bodies and improves the behavioral and neurological outcomes observed with late treatment (during 2 months at 10 months of age). We also evaluated the benefits of...
Source: Neurotherapeutics - October 27, 2022 Category: Neurology Source Type: research
Clinical and Translational Advances in Glioma Immunotherapy
AbstractGliomas are highly treatment refractory against immune checkpoint blockade, an immunotherapeutic modality that revolutionized therapy for many tumors. At the same time, technological innovation has dramatically accelerated the development of immunotherapeutic approaches such as personalized tumor-specific vaccine production, dendritic cell vaccine manufacture, patient-individual target selection and chimeric antigen receptor, and T cell receptor T cell manufacture. Here we review recent clinical and translational advances in glioma immunotherapy with a focus on targets and their cognate immune receptor derivates as...
Source: Neurotherapeutics - October 27, 2022 Category: Neurology Source Type: research
Commentary on: A Network Approach to Understanding the Effects of Focused Ultrasound for Essential Tremor: Insights into Pathophysiology, Treatment, and Imaging Biomarkers
(Source: Neurotherapeutics)
Source: Neurotherapeutics - October 27, 2022 Category: Neurology Source Type: research
CSF IL-8 Associated with Response to Gene Therapy in a Case Series of Spinal Muscular Atrophy
AbstractGene therapies have greatly changed the outlook in spinal muscular atrophy (SMA), and this disorder provides a rare opportunity to study longitudinal biomarker changes correlated with reduced disease burden and improved clinical outcomes. Recent work suggests clinical response to correlate with declining cerebrospinal fluid (CSF) levels of the neurodegenerative marker neurofilament light chain (NfL) in children receiving serial anti-sense oligonucleotide therapy. However, change in CSF NfL levels is no longer a practical biomarker as more children undergo single-dose gene replacement therapy. Here we leverage seria...
Source: Neurotherapeutics - October 26, 2022 Category: Neurology Source Type: research
Novel Cross-Correction –Enabled Gene Therapy for CDKL5-Deficiency Disorder
(Source: Neurotherapeutics)
Source: Neurotherapeutics - October 20, 2022 Category: Neurology Source Type: research
Better Fields or Currents? A Head-to-Head Comparison of Transcranial Magnetic (rTMS) Versus Direct Current Stimulation (tDCS) for Neuropathic Pain
AbstractWhile high-frequency transcranial magnetic stimulation (HF-rTMS) is now included in the armamentarium to treat chronic neuropathic pain (NP), direct-current anodal stimulation (a-tDCS) to the same cortical targets may represent a valuable alternative in terms of feasibility and cost. Here we performed a head-to-head, randomized, single-blinded, cross-over comparison of HF-rTMS versus a-tDCS over the motor cortex in 56 patients with drug-resistant NP, who received 5 daily sessions of each procedure, with a washout of at least 4 weeks. Daily scores of pain, sleep, and fatigue were obtained during 5 consecutive week...
Source: Neurotherapeutics - October 20, 2022 Category: Neurology Source Type: research
Novel Cross-Correction –Enabled Gene Therapy for CDKL5-Deficiency Disorder
(Source: Neurotherapeutics)
Source: Neurotherapeutics - October 20, 2022 Category: Neurology Source Type: research
Better Fields or Currents? A Head-to-Head Comparison of Transcranial Magnetic (rTMS) Versus Direct Current Stimulation (tDCS) for Neuropathic Pain
AbstractWhile high-frequency transcranial magnetic stimulation (HF-rTMS) is now included in the armamentarium to treat chronic neuropathic pain (NP), direct-current anodal stimulation (a-tDCS) to the same cortical targets may represent a valuable alternative in terms of feasibility and cost. Here we performed a head-to-head, randomized, single-blinded, cross-over comparison of HF-rTMS versus a-tDCS over the motor cortex in 56 patients with drug-resistant NP, who received 5 daily sessions of each procedure, with a washout of at least 4 weeks. Daily scores of pain, sleep, and fatigue were obtained during 5 consecutive week...
Source: Neurotherapeutics - October 20, 2022 Category: Neurology Source Type: research
Through the Looking Glass: The Paradoxical Evolution of Targeted Temperature Management for Comatose Survivors of Cardiac Arrest
AbstractFor the past two decades, targeted temperature management (TTM) has been a staple in the care of comatose survivors following cardiac arrest. However, recent clinical trials have failed to replicate the benefit seen in earlier studies, bringing into question the very existence of such clinical practice. In this review, we explore clinical scenarios within critical care that appeared to share a similar fate, but in actuality changed the landscape of practice in a modern world. Accordingly, clinicians may apply these lessons to the utilization of TTM among comatose survivors following cardiac arrest, potentially pavi...
Source: Neurotherapeutics - October 17, 2022 Category: Neurology Source Type: research
