Commentary: Modern Hearing Preservation Outcomes After Vestibular Schwannoma Stereotactic Radiosurgery
No abstract available (Source: Neurosurgery)
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Commentary: Radiation Oncology Source Type: research
Commentary: Time to Follow Commands in Severe Traumatic Brain Injury Survivors With Favorable Recovery at 2 Years
No abstract available (Source: Neurosurgery)
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Commentary: Neurotrauma Source Type: research
Commentary: Prognostic Significance of Baseline Frailty Status in Traumatic Spinal Cord Injury
No abstract available (Source: Neurosurgery)
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Commentary: Spine Source Type: research
Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol
DISCUSSION:
A successful trial will support the decision to proceed to advanced phase trials. Any tumor penetration by PCZ, with concomitant effect on glycolysis, warrants further in-depth analysis, as therapeutic options for these deadly tumors are currently limited. (Source: Neurosurgery)
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Research—Human—Study Protocols: Tumor Source Type: research
Modern Hearing Preservation Outcomes After Vestibular Schwannoma Stereotactic Radiosurgery
CONCLUSION:
Hearing preservation after SRS for patients with VS with serviceable hearing is correlated to the specific baseline GR score (1 or 2), age, cochlear dose, and biological effective dose. Increased tumor-free canal space correlates with better outcomes. The most durable hearing preservation correlates with factors commonly associated with smaller tumors away from the cochlea. (Source: Neurosurgery)
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Radiation Oncology Source Type: research
Matched Comparison of Hearing Outcomes in Patients With Vestibular Schwannoma Treated With Stereotactic Radiosurgery or Observation
CONCLUSION:
When controlling for potential confounders, there was no significant difference in loss of class A or serviceable hearing between patients managed with SRS or with observation alone. (Source: Neurosurgery)
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Tumor Source Type: research
Time to Follow Commands in Severe Traumatic Brain Injury Survivors With Favorable Recovery at 2 Years
BACKGROUND:
The recovery of severe traumatic brain injury (TBI) survivors with long-term favorable outlook is understudied. Time to follow commands varies widely in this patient population but has important clinical implications.
OBJECTIVE:
To (1) evaluate time to follow commands in severe patients with TBI with favorable outcomes, (2) characterize their trajectory of recovery, and (3) identify predictors associated with delayed cognitive improvement.
METHODS:
Participants were recruited prospectively at a Level I trauma center through the Brain Trauma Research Center from 2003 to 2018. Inclusion criteria...
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Neurotrauma Source Type: research
Multinational Genome-Wide Association Study and Functional Genomics Analysis Implicates Decreased SIRT3 Expression Underlying Intracranial Aneurysm Risk
CONCLUSION:
We perform a multinational GWAS of IA and identify 4 genetic risk loci, including 2 novel IA risk loci (SIRT3 and AL359922.1). Identification of high-risk genetic loci across ancestries will enable population-genetic screening approaches to identify patients with IA. (Source: Neurosurgery)
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Cerebrovascular Source Type: research
Not Just an Anchor: The Human Filum Terminale Contains Stretch Sensitive and Nociceptive Nerve Endings and Responds to Electrical Stimulation With Paraspinal Muscle Activation
CONCLUSION:
Morphological and electrophysiological results indicate the presence of functional sensory nerve endings in the FT. Like other spine ligaments, the FT may serve as a proprioceptive element but may also contribute to back pain in spine disorders. (Source: Neurosurgery)
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Spine Source Type: research
Responder Analysis of Pain Relief After Surgery for the Treatment of Spinal Metastatic Tumors
CONCLUSION:
Although patients with milder preoperative symptoms are likely to achieve better pain relief after surgery, patients with worse preoperative symptom also benefit from surgery with adequate pain relief with an improvement in physical function. (Source: Neurosurgery)
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Spine Source Type: research
Endovascular Recanalization for Acute Internal Carotid Artery Terminus Occlusion: A Subgroup Analysis From the Direct-MT Trial
BACKGROUND:
The efficacy of endovascular recanalization for internal carotid artery (ICA) terminus occlusion has not been completely evaluated.
OBJECTIVE:
To investigate the efficacy of endovascular recanalization for ICA terminus occlusion.
METHODS:
Data from Direct-MT, a randomized controlled trial, were applied. ICA terminus occlusions were diagnosed with preprocedure computed tomography angiography by the core laboratory. We dichotomized the ICA terminus occlusions into 2 groups (non-T and T) and analyzed the differences between them. Single-factor analysis and multiple logistic regression were applie...
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Endovascular Source Type: research
Association of Language Barriers With Process Outcomes After Craniotomy for Brain Tumor
BACKGROUND:
Little is known about the independent association of language barriers on postoperative process outcomes after craniotomies.
OBJECTIVE:
To evaluate the association of limited English proficiency (LEP) with length of stay (LOS), discharge disposition, hospitalization costs, and rate of 30-day readmission after craniotomy for brain tumor.
METHODS:
This is a retrospective cohort study of adult patients who underwent craniotomies for brain tumor from 2015 to 2019 at a high-volume neurosurgical center. Multivariable logistic regression was used to evaluate the association of LEP with discharge disp...
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Socioeconomics, Health Policy and Law Source Type: research
Interictal Connectivity Revealed by Granger Analysis of Stereoelectroencephalography: Association With Ictal Onset Zone, Resection, and Outcome
BACKGROUND:
Stereoelectroencephalography (sEEG) facilitates electrical sampling and evaluation of complex deep-seated, dispersed, and multifocal locations. Granger causality (GC), previously used to study seizure networks using interictal data from subdural grids, may help identify the seizure-onset zone from interictal sEEG recordings.
OBJECTIVE:
To examine whether statistical analysis of interictal sEEG helps identify surgical target sites and whether surgical resection of highly ranked nodes correspond to favorable outcomes.
METHODS:
Ten minutes of extraoperative recordings from sequential patients who...
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Stereotactic Functional Source Type: research
Prognostic Significance of Baseline Frailty Status in Traumatic Spinal Cord Injury
BACKGROUND:
Literature evaluating frailty in traumatic spinal cord injury (tSCI) is limited.
OBJECTIVE:
To evaluate the prognostic significance of baseline frailty status in tSCI.
METHODS:
Patients with tSCI were identified in the National Inpatient Sample from 2015 to 2018 and stratified according to frailty status, which was quantified using the 11-point modified frailty index (mFI).
RESULTS:
Among 8825 operatively managed patients with tSCI identified (mean age 57.9 years, 27.6% female), 3125 (35.4%) were robust (mFI = 0), 2530 (28.7%) were prefrail (mFI = 1), 1670 (18.9%) were frail (mFI = 2), ...
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Neurotrauma Source Type: research
Facial Nerve Massage for the Treatment of Hemifacial Spasm Refractory to Microvascular Decompression: Outcomes and Complications
BACKGROUND:
After microvascular decompression (MVD) for hemifacial spasm (HFS), a minority of patients realize little to no relief of spasms. In some patients, the absence of relief of spasms results from incomplete or inadequate decompression of vascular compression of the facial nerve, and these patients represent excellent candidates for repeat MVD. However, in other patients, repeat MVD is not appropriate because adequate decompression and resolution of neurovascular compression, as determined by postoperative high-resolution MRI, was achieved with the initial operation.
OBJECTIVE:
To present a cohort of pat...
Source: Neurosurgery - September 16, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Stereotactic Functional Source Type: research
