Complete Response of a Patient With a Mismatch Repair Deficient Aggressive Pituitary Adenoma to Immune Checkpoint Inhibitor Therapy: A Case Report
CONCLUSION:
APA is a tumor with frequent recurrence and a short median expected length of survival. Here, we demonstrate the utility of immunotherapy in a single case report of APA, with complete resolution of recurrent APA and improved survival compared with life expectancy. (Source: Neurosurgery)
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Case Report: Tumor Source Type: research
Predictors for Withdrawal of Life-Sustaining Therapies in Patients With Traumatic Brain Injury: A Retrospective Trauma Quality Improvement Program Database Study
Many patients with severe traumatic brain injuries (TBIs) undergo withdrawal of life-sustaining therapies (WLSTs) or transition to comfort measures, but noninjury factors that influence this decision have not been well characterized. We hypothesized that WLST would be associated with institutional and geographic noninjury factors. All patients with a head Abbreviated Injury Scale score ≥3 were identified from 2016 Trauma Quality Improvement Program data. We analyzed factors that might be associated with WLST, including procedure type, age, sex, race, insurance, Glasgow Coma Scale score, mechanism of injury, geographic re...
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Special Article: Neurotrauma Source Type: research
Commentary: Characteristics of Sagittal Spinopelvic Alignment Changes After Symptom Relief After Simple Lumbar Decompression
No abstract available (Source: Neurosurgery)
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Commentary: Spine Source Type: research
Commentary: Machine Learning to Predict Successful Opioid Dose Reduction or Stabilization After Spinal Cord Stimulation
No abstract available (Source: Neurosurgery)
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Commentary: Stereotactic Functional Source Type: research
Transcriptomic Profiling Revealed Lnc-GOLGA6A-1 as a Novel Prognostic Biomarker of Meningioma Recurrence
BACKGROUND:
Meningioma is the most common primary central nervous system neoplasm, accounting for about a third of all brain tumors. Because their growth rates and prognosis cannot be accurately estimated, biomarkers that enable prediction of their biological behavior would be clinically beneficial.
OBJECTIVE:
To identify coding and noncoding RNAs crucial in meningioma prognostication and pathogenesis.
METHODS:
Total RNA was purified from formalin-fixed and paraffin-embedded tumor samples of 64 patients with meningioma with distinct clinical characteristics (16 recurrent, 30 nonrecurrent with follow-up of...
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Research—Laboratory: Tumor Source Type: research
Protocol for a Multicenter, Prospective, Observational Pilot Study on the Implementation of Resource-Stratified Algorithms for the Treatment of Severe Traumatic Brain Injury Across Four Treatment Phases: Prehospital, Emergency Department, Neurosurgery, and Intensive Care Unit
DISCUSSION:
This pilot study will serve as a first step to identify variables that are critical to successful implementation, to be considered for the design of a future large-scale international study to measure the effectiveness of resource-based protocols and to improve outcomes from sTBI. (Source: Neurosurgery)
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Research—Human—Study Protocols: Neurotrauma Source Type: research
Acute Postoperative Seizures and Engel Class Outcome at 1 Year Postselective Laser Amygdalohippocampal Ablation for Mesial Temporal Lobe Epilepsy
CONCLUSION:
APOS was associated with a lower chance of seizure freedom at 1 year post-MRgLITT for mesial temporal lobe epilepsy. Amygdala, hippocampal, entorhinal, and parahippocampal residual volumes after ablation were not significant prognostic factors. (Source: Neurosurgery)
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Stereotactic Functional Source Type: research
Access Site Complications and Management of the Transradial Approach for Neurointerventions
CONCLUSION:
Transradial access for neurointervention has a low rate of local complications, particularly when taking appropriate prevention measures. Appropriate management of complications can prevent procedural failure and has low morbidity rates demonstrating the overall safety profile of transradial access even when complications occur. (Source: Neurosurgery)
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Endovascular Source Type: research
Characteristics of Sagittal Spinopelvic Alignment Changes After Symptom Relief After Simple Lumbar Decompression
CONCLUSION:
Patients with pain on standing within 10 minutes showed significant correction in RSA, RLL, and GAP values after simple lumbar decompression. Therefore, it is important to observe such clinical symptoms to avoid misdiagnosis of ASD. (Source: Neurosurgery)
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Spine Source Type: research
Pragmatic Prediction of Excessive Length of Stay After Cervical Spine Surgery With Machine Learning and Validation on a National Scale
CONCLUSION:
Machine learning algorithms accurately predict extended LOS across single-center and national patient cohorts and characterize key preoperative drivers of increased LOS after cervical spine surgery. (Source: Neurosurgery)
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Spine Source Type: research
Association of Patient Frailty With Vestibular Schwannoma Resection Outcomes and Machine Learning Development of a Vestibular Schwannoma Risk Stratification Score
BACKGROUND:
Patient frailty is predictive of higher neurosurgical morbidity and mortality. However, existing frailty measures are hindered by lack of specificity to neurosurgery.
OBJECTIVE:
To analyze the association between 3 risk stratification scores and outcomes for nationwide vestibular schwannoma (VS) resection admissions and develop a custom VS risk stratification score.
METHODS:
We identified all VS resection admissions in the National Inpatient Sample (2002-2017). Three risk stratification scores were analyzed: modified Frailty Index-5, modified Frailty Index-11(mFI-11), and Charlson Comorbidity ...
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Tumor Source Type: research
Randomized Trial Comparing Burr Hole Craniostomy, Minicraniotomy, and Twist Drill Craniostomy for Treatment of Chronic Subdural Hematoma
BACKGROUND:
The mainstay of treatment for symptomatic or large chronic subdural hematoma (CSDH) is surgery, but controversy still exists regarding the best surgical technique. Three different techniques are commonly used: burr hole craniostomy (BHC), minicraniotomy (MC), and twist drill craniostomy (TDC).
OBJECTIVE:
To determine which surgical technique for drainage of CSDH offers best results.
METHODS:
We set up a multicenter prospective randomized trial (Comparison of Chronic Subdural Hematoma Treatment [COMPACT] trial) comparing BHC, MC, and TDC for the surgical treatment of CSDH. The primary end point...
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Neurotrauma Source Type: research
A Special Approach for Stereotactic Radiofrequency Thermocoagulation of Hypothalamic Hamartomas With Bilateral Attachments to the Hypothalamus: The Transthird Ventricular Approach to the Contralateral Attachment
CONCLUSION:
SRT-TT enabled disconnection of bilateral attachments of HHs in a single-staged procedure, which reduced the additional invasiveness of reoperation. Moreover, SRT-TT reduced damage to the contralateral hypothalamus, with fewer endocrinological complications than the bilateral approach. (Source: Neurosurgery)
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Stereotactic Functional Source Type: research
Combined Nerve and Tendon Transfers for C7-T1 Brachial Plexus Avulsion Injury
CONCLUSION:
Combined nerve and tendon transfers are reliable and effective. This strategy could be an option for hand function reconstruction after C7-T1 brachial plexus injury. (Source: Neurosurgery)
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Peripheral Nerve Source Type: research
The Pennsylvania Postmarket Multicenter Experience With Flow Redirection Endoluminal Device
CONCLUSION:
The results of the early postmarket experience with the FRED device show reasonable safety and adequate aneurysmal occlusion rates comparable with other flow diverters. However, more extensive multicenter studies with more extended follow-up data are needed to assess the long-term safety and durability of the device. (Source: Neurosurgery)
Source: Neurosurgery - July 21, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Cerebrovascular Source Type: research
