Dose-Dependent Tranexamic Acid Blunting of Penumbral Leukocyte Mobilization and Blood –Brain Barrier Permeability Following Traumatic Brain Injury: An In Vivo Murine Study
ConclusionsOnly higher TXA dosing definitively abrogates penumbral leukocyte mobilization, preserving BBB integrity post TBI. Some neuroclinical recovery is observed, even with lower TXA dosing. Better outcomes with higher dose TXA after TBI may occur secondary to blunting of leukocyte-mediated penumbral cerebrovascular inflammation. (Source: Neurocritical Care)
Source: Neurocritical Care - March 5, 2024 Category: Neurology Source Type: research
Noninvasive Intracranial Pressure Monitoring: Are We There Yet?
AbstractThere is an urgent unmet need for a reliable noninvasive tool to detect elevations in intracranial pressure (ICP) above guideline-recommended thresholds for treatment. Gold standard invasive ICP monitoring is unavailable in many settings, including resource-limited environments, and in situations such as liver failure in which coagulopathy increases the risk of invasive monitoring. Although a large number of noninvasive techniques have been evaluated, this article reviews the potential clinical role, if any, of the techniques that have undergone the most extensive evaluation and are already in clinical use. Elevati...
Source: Neurocritical Care - March 1, 2024 Category: Neurology Source Type: research
Association Between Early Mobilization and Functional Outcomes in Patients with Aneurysmal Subarachnoid Hemorrhage: A Multicenter Retrospective Propensity Score-Matched Study
ConclusionsThis multicenter retrospective study suggests that initiating walking training within 14 days of aSAH onset is associated with favorable outcomes. (Source: Neurocritical Care)
Source: Neurocritical Care - March 1, 2024 Category: Neurology Source Type: research
Variations in Autoregulation-Based Optimal Cerebral Perfusion Pressure Determination Using Two Integrated Neuromonitoring Platforms in a Trauma Patient
ConclusionsThese wide variations recorded in the same patient are worrisome and reiterate the importance of understanding and standardizing the methodology and algorithms behind commercial neuromonitoring devices prior to incorporating them in clinical use. (Source: Neurocritical Care)
Source: Neurocritical Care - February 29, 2024 Category: Neurology Source Type: research
The Invisible Effect of Recruitment Maneuvers in Acute Brain Injury
(Source: Neurocritical Care)
Source: Neurocritical Care - February 27, 2024 Category: Neurology Source Type: research
Current Concepts in Early Mobilization of Critically Ill Patients Within the Context of Neurologic Pathology
AbstractNeurocritical patients (NCPs) in the intensive care unit (ICU) rapidly progress to respiratory and peripheral muscle dysfunctions, which significantly impact morbidity and death. Early mobilization in NCPs to decrease the incidence of ICU –acquired weakness has been showing rapid growth, although pertinent literature is still scarce. With this review, we summarize and discuss current concepts in early mobilization of critically ill patients within the context of neurologic pathology in NCPs. A narrative synthesis of literature was undertaken trying to answer the following questions: How do the respiratory and mus...
Source: Neurocritical Care - February 23, 2024 Category: Neurology Source Type: research
Safety and Effect on Intracranial Pressure of 3% Hypertonic Saline Bolus Via Peripheral Intravenous Catheter for Neurological Emergencies
ConclusionsRapid bolus administration of 3% HTS via PIV catheters presents itself as a relatively safe approach to treat neurological emergencies. Its implementation could provide an invaluable alternative to the traditional CVC-based administration, potentially minimizing CVC-associated complications and expediting life-saving interventions for patients with neurological emergencies, especially in the field and emergency department settings. (Source: Neurocritical Care)
Source: Neurocritical Care - February 20, 2024 Category: Neurology Source Type: research
Sex Differences in Perihematomal Edema Volume and Outcome After Intracerebral Hemorrhage
ConclusionsEarly PHE expansion and trajectory in men were significantly higher. PHE expansion was associated with poor outcomes independent of sex. Mechanisms leading to sex differences in PHE trajectories merit further investigation. (Source: Neurocritical Care)
Source: Neurocritical Care - February 20, 2024 Category: Neurology Source Type: research
A “Feed”-Back on EEG Monitoring Artifacts
(Source: Neurocritical Care)
Source: Neurocritical Care - February 20, 2024 Category: Neurology Source Type: research
Guidelines for Neuroprognostication in Critically Ill Adults with Moderate –Severe Traumatic Brain Injury
ConclusionsThese guidelines provide recommendations to clinicians on the formal reliability of individual predictors and prediction models of poor outcome when counseling surrogates of patients with msTBI and suggest broad principles of neuroprognostication. (Source: Neurocritical Care)
Source: Neurocritical Care - February 17, 2024 Category: Neurology Source Type: research
ICP Monitoring for Bacterial Meningitis: Is This Just One of the Blind Spots in Neurocritical Care?
(Source: Neurocritical Care)
Source: Neurocritical Care - February 17, 2024 Category: Neurology Source Type: research
Detection and Management of Elevated Intracranial Pressure in the Treatment of Acute Community-Acquired Bacterial Meningitis: A Systematic Review
AbstractAcute bacterial meningitis (ABM) is associated with severe morbidity and mortality. The most prevalent pathogens in community-acquired ABM areStreptococcus pneumoniae,Neisseria meningitidis, andHaemophilus influenzae. Other pathogens may affect specific patient groups, such as newborns, older patients, or immunocompromised patients. It is well established that ABM is associated with elevated intracranial pressure (ICP). However, the role of ICP monitoring and management in the treatment of ABM has been poorly described.An electronic search was performed in four electronic databases: PubMed, Web of Science, Embase, ...
Source: Neurocritical Care - February 14, 2024 Category: Neurology Source Type: research
Temporal Changes in CSF Cell Parameters After SAH: Comparison of Ventricular and Spinal Drain Samples
ConclusionsCSF cell parameters undergo dynamic temporal changes after aSAH. CSF samples from different CSF compartments are not comparable. (Source: Neurocritical Care)
Source: Neurocritical Care - February 14, 2024 Category: Neurology Source Type: research
Assessing Acute Brain Injury after Rapid Reduction of PaCO2 using Plasma Biomarkers in Patients Undergoing ECMO
(Source: Neurocritical Care)
Source: Neurocritical Care - February 14, 2024 Category: Neurology Source Type: research
Necrotizing Pneumonia and Cerebral Air Embolism
(Source: Neurocritical Care)
Source: Neurocritical Care - February 14, 2024 Category: Neurology Source Type: research
