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Case Report of Graves' Disease in a 45-Year-Old Woman Secondary to Herceptin Treatment for Breast Cancer
Monoclon Antib Immunodiagn Immunother. 2023 Dec;42(6):194-202. doi: 10.1089/mab.2023.0011.ABSTRACTGraves' disease is the most common cause of thyrotoxicosis and is characterized by ophthalmopathy with proptosis, chemosis, or conjunctival injection; pretibial myxedema; and thyroid acropachy. It is an autoimmune disease that can be genetic or influenced by coexisting environmental factors such as exposure to anticancer drugs, including immune checkpoint inhibitors. The incidence rate of breast cancer is increasing due to rising awareness of risk factors and screening for breast cancer, and the mortality rate is decreasing du...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - December 29, 2023 Category: Microbiology Authors: Chinmeri U Achonu Oluwarotimi B Olopade Bashir O Yusuf Abimbola A Fadeyi Olufemi A Fasanmade Source Type: research

Epitope Mapping of an Anti-ferret Podoplanin Monoclonal Antibody Using the PA Tag-Substituted Analysis
In this study, we determined the critical epitope of PMab-292 using flow cytometry. The ferPDPN deletion mutants analysis revealed that the Val34 is located at the N-terminus of the PMab-292 epitope. Furthermore, the PA tag-substituted analysis (PA scanning) showed that Asp39 is located at the C-terminus of PMab-292 epitope. The epitope sequence (VRPEDD) also exists between Val26 and Asp31 of ferPDPN, indicating that PMab-292 recognizes the tandem repeat of the VRPEDD sequence of ferPDPN.PMID:38156889 | DOI:10.1089/mab.2023.0026 (Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy)
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - December 29, 2023 Category: Microbiology Authors: Yu Isoda Mika K Kaneko Tomohiro Tanaka Hiroyuki Suzuki Yukinari Kato Source Type: research

Monoclonal Antibodies 4B11 and 6D7 Against SARS-CoV-2 Nucleocapsid Protein
Monoclon Antib Immunodiagn Immunother. 2023 Dec;42(6):217. doi: 10.1089/mab.2023.0028.NO ABSTRACTPMID:38156890 | DOI:10.1089/mab.2023.0028 (Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy)
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - December 29, 2023 Category: Microbiology Source Type: research

PMab-301: An Anti-Giraffe Podoplanin Monoclonal Antibody for Immunohistochemistry
In this study, we established a novel anti-giraffe PDPN (girPDPN) mAb, PMab-301, using the Cell-Based Immunization and Screening (CBIS) method. PMab-301 (mouse IgG1, kappa) detected girPDPN in various applications, such as flow cytometry, western blot, and immunohistochemistry. PMab-301 specifically stained type-I alveolar cells using formalin-fixed paraffin-embedded giraffe lung tissues. Our findings suggest the potential usefulness of PMab-301 for the pathophysiological analyses of giraffe tissues.PMID:38150189 | DOI:10.1089/mab.2023.0020 (Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy)
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - December 27, 2023 Category: Microbiology Authors: Tsunenori Ouchida Tomohiro Tanaka Hiroyuki Suzuki Kazuyuki Uchida Takayuki Nakagawa Guanjie Li Takuro Nakamura Miyuki Yanaka Saori Handa Mika K Kaneko Yukinari Kato Source Type: research

Is It Time to Re-Evaluate?
Monoclon Antib Immunodiagn Immunother. 2023 Dec 22. doi: 10.1089/mab.2023.29016.editorial. Online ahead of print.NO ABSTRACTPMID:38133517 | DOI:10.1089/mab.2023.29016.editorial (Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy)
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - December 22, 2023 Category: Microbiology Authors: Thomas Kieber-Emmons Source Type: research