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Should We Be Worried
Monoclon Antib Immunodiagn Immunother. 2024 Feb 16. doi: 10.1089/mab.2024.29017.editorial. Online ahead of print.NO ABSTRACTPMID:38364115 | DOI:10.1089/mab.2024.29017.editorial (Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy)
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - February 16, 2024 Category: Microbiology Authors: Thomas Kieber-Emmons Source Type: research

Establishment of Anti-Dog Programmed Cell Death Ligand 1 Monoclonal Antibodies for Immunohistochemistry
In this study, we immunized the peptide in the dPD-L1 intracellular domain, and established anti-dPD-L1 mAbs, L1Mab-352 (mouse IgG1, kappa), and L1Mab-354 (mouse IgG1, kappa). In enzyme-linked immunosorbent assay, L1Mab-352 and L1Mab-354 showed high-binding affinity to the dPD-L1 peptide, and the dissociation constants (KD) were determined as 6.9 × 10-10 M and 7.2 × 10-10 M, respectively. Furthermore, L1Mab-352 and L1Mab-354 were applicable for the detection of dPD-L1 in immunohistochemical analysis in paraffin-embedded dPD-L1-overexpressed cells. These results indicated that L1Mab-352 and L1Mab-354 are useful for detect...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - January 18, 2024 Category: Microbiology Authors: Tsunenori Ouchida Hiroyuki Suzuki Tomohiro Tanaka Mika K Kaneko Yukinari Kato Source Type: research

Development of a Sensitive Anti-Mouse CD39 Monoclonal Antibody (C < sub > 39 < /sub > Mab-1) for Flow Cytometry and Western Blot Analyses
This study developed specific and sensitive mAbs for mouse CD39 (mCD39) using the Cell-Based Immunization and Screening method. The established anti-mCD39 mAb, C39Mab-1 (rat IgG2a, kappa), reacted with mCD39-overexpressed Chinese hamster ovary-K1 (CHO/mCD39) by flow cytometry. The kinetic analysis using flow cytometry indicated that the dissociation constant of C39Mab-1 for CHO/mCD39 was 7.3 × 10-9 M. Furthermore, C39Mab-1 detected the lysate of CHO/mCD39 by western blot analysis. These results indicated that C39Mab-1 is useful for the detection of mCD39 in many functional studies.PMID:38197855 | DOI:10.1089/mab.2023.0016...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - January 10, 2024 Category: Microbiology Authors: Yuki Okada Hiroyuki Suzuki Mika K Kaneko Yukinari Kato Source Type: research

Case Report of Graves' Disease in a 45-Year-Old Woman Secondary to Herceptin Treatment for Breast Cancer
Monoclon Antib Immunodiagn Immunother. 2023 Dec;42(6):194-202. doi: 10.1089/mab.2023.0011.ABSTRACTGraves' disease is the most common cause of thyrotoxicosis and is characterized by ophthalmopathy with proptosis, chemosis, or conjunctival injection; pretibial myxedema; and thyroid acropachy. It is an autoimmune disease that can be genetic or influenced by coexisting environmental factors such as exposure to anticancer drugs, including immune checkpoint inhibitors. The incidence rate of breast cancer is increasing due to rising awareness of risk factors and screening for breast cancer, and the mortality rate is decreasing du...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - December 29, 2023 Category: Microbiology Authors: Chinmeri U Achonu Oluwarotimi B Olopade Bashir O Yusuf Abimbola A Fadeyi Olufemi A Fasanmade Source Type: research

Epitope Mapping of an Anti-ferret Podoplanin Monoclonal Antibody Using the PA Tag-Substituted Analysis
In this study, we determined the critical epitope of PMab-292 using flow cytometry. The ferPDPN deletion mutants analysis revealed that the Val34 is located at the N-terminus of the PMab-292 epitope. Furthermore, the PA tag-substituted analysis (PA scanning) showed that Asp39 is located at the C-terminus of PMab-292 epitope. The epitope sequence (VRPEDD) also exists between Val26 and Asp31 of ferPDPN, indicating that PMab-292 recognizes the tandem repeat of the VRPEDD sequence of ferPDPN.PMID:38156889 | DOI:10.1089/mab.2023.0026 (Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy)
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - December 29, 2023 Category: Microbiology Authors: Yu Isoda Mika K Kaneko Tomohiro Tanaka Hiroyuki Suzuki Yukinari Kato Source Type: research