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Global interactome mapping reveals pro-tumorigenic interactions of NF- κB in breast cancer
This study describes a network of pro-tumorigenic protein interactions and their rearrangement upon NF-κB inhibition with potential therapeutic implications in tumors with high NF-κB activity.PMID:38417630 | DOI:10.1016/j.mcpro.2024.100744 (Source: Molecular and Cellular Proteomics : MCP)
Source: Molecular and Cellular Proteomics : MCP - February 28, 2024 Category: Molecular Biology Authors: Petr Lapcik R Greg Stacey David Potesil Petr Kulhanek Leonard J Foster Pavel Bouchal Source Type: research

pXg: Comprehensive identification of noncanonical MHC-I-associated peptides from de novo peptide sequencing using RNA-Seq reads
Mol Cell Proteomics. 2024 Feb 23:100743. doi: 10.1016/j.mcpro.2024.100743. Online ahead of print.ABSTRACTDiscovering noncanonical peptides has been a common application of proteogenomics. Recent studies suggest that certain noncanonical peptides, known as ncMAPs (noncanonical MHC-I-associated peptides), that bind to major histocompatibility complex I may make good immunotherapeutic targets. De novo peptide sequencing is a great way to find ncMAPs since it can detect peptide sequences from their tandem mass spectra without using any sequence databases. However, this strategy hasn't been widely applied for ncMAP identificati...
Source: Molecular and Cellular Proteomics : MCP - February 25, 2024 Category: Molecular Biology Authors: Seunghyuk Choi Eunok Paek Source Type: research

Phosphorothioate RNA Analysis by NETD Tandem Mass Spectrometry
Mol Cell Proteomics. 2024 Feb 22:100742. doi: 10.1016/j.mcpro.2024.100742. Online ahead of print.ABSTRACTTherapeutic ribonucleic acids (RNAs) are routinely modified during their synthesis to ensure proper drug uptake, stability, and efficacy. Phosphorothioate (PS) RNA, molecules in which one or more backbone phosphates are modified with a sulfur atom in place of standard non-bridging oxygen, is one of the most common modifications due to ease of synthesis and pharmacokinetic benefits. Quality assessment of RNA synthesis, including modification incorporation, is essential for drug selectivity and performance, and the synthe...
Source: Molecular and Cellular Proteomics : MCP - February 24, 2024 Category: Molecular Biology Authors: Trenton M Peters-Clarke Qiuwen Quan Benton J Anderson William M McGee Emily Lohr Alexander S Hebert Michael S Westphall John E P Syka James L Stephenson Joshua J Coon Source Type: research

Selective modulation of the human glucocorticoid receptor compromises GR chromatin occupancy and recruitment of p300/CBP and the Mediator complex
Mol Cell Proteomics. 2024 Feb 20:100741. doi: 10.1016/j.mcpro.2024.100741. Online ahead of print.ABSTRACTExogenous glucocorticoids are frequently used to treat inflammatory disorders and as adjuncts for the treatment of solid cancers. However, their use is associated with severe side effects and therapy resistance. Novel glucocorticoid receptor (GR) ligands with a patient-validated reduced side effect profile have not yet reached the clinic. GR is a member of the nuclear receptor family of transcription factors and heavily relies on interactions with coregulator proteins for its transcriptional activity. To elucidate the r...
Source: Molecular and Cellular Proteomics : MCP - February 22, 2024 Category: Molecular Biology Authors: Laura Van Moortel Annick Verhee Jonathan Thommis Ren é Houtman Diana Melchers Louis Delhaye Chlo é Van Leene Madeleine Hellemans Kris Gevaert Sven Eyckerman Karolien De Bosscher Source Type: research

The Quantitative Biotinylproteomics Studies Reveal a WInd-Related Kinase 1 (WIRK1) Functioning as An Early Signaling Component in Wind-induced Thigmomorphogenesis and Gravitropism
Mol Cell Proteomics. 2024 Feb 14:100738. doi: 10.1016/j.mcpro.2024.100738. Online ahead of print.ABSTRACTWind is one of the most prevalent environmental forces entraining plants to develop various mechano-responses, collectively called thigmomorphogenesis. Largely unknown is how plants transduce these versatile wind force signals downstream to nuclear events and to the development of thigmomorphogenic phenotype or anemotropic response. To identify molecular components at the early steps of the wind force signaling, two mechanical signaling-related phosphoproteins, identified from our previous phosphoproteomic study of Arab...
Source: Molecular and Cellular Proteomics : MCP - February 16, 2024 Category: Molecular Biology Authors: Nan Yang Jia Ren Shuaijian Dai Kai Wang Manhin Leung Yinglin Lu Yuxing An Al Burlingame Shouling Xu Zhiyong Wang Weichuan Yu Ning Li Source Type: research

Personalized drug therapy: innovative concept guided with proteoformics
Mol Cell Proteomics. 2024 Feb 12:100737. doi: 10.1016/j.mcpro.2024.100737. Online ahead of print.ABSTRACTPersonalized medicine can reduce adverse effects, enhance drug efficacy, and optimize treatment outcomes, which represents the essence of personalized medicine in the pharmacy field. Protein drugs are crucial in the field of personalized drug therapy and are currently the mainstay, which possess higher target specificity and biological activity compared to small-molecule chemical drugs, making them efficient in regulating disease-related biological processes, and have significant potential in the development of personal...
Source: Molecular and Cellular Proteomics : MCP - February 14, 2024 Category: Molecular Biology Authors: Junwen Su Lamei Yang Ziran Sun Xianquan Zhan Source Type: research