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The Salmonella Typhimurium effector SpvB subverts host membrane trafficking by targeting clathrin and AP-1
Mol Cell Proteomics. 2023 Nov 2:100674. doi: 10.1016/j.mcpro.2023.100674. Online ahead of print.ABSTRACTSalmonella enterica, the etiological agent of gastrointestinal and systemic diseases, translocates a plethora of virulence factors through its type III secretion systems (T3SSs) to host cells during infection. Among them, SpvB has been reported to harbor an ADP-ribosyltransferase domain in its C-terminus, which destabilizes host cytoskeleton by modifying actin. However, whether this effector targets other host factors as well as the function of its N-terminus still remains to be determined. Here, we found that SpvB targe...
Source: Molecular and Cellular Proteomics : MCP - November 4, 2023 Category: Molecular Biology Authors: Yi Yuan Xinghao Wang Jie Jin Zhiheng Tang Wei Xian Xinyi Zhang Jiaqi Fu Kangmin He Xiaoyun Liu Source Type: research

Proteomics, Transcriptomics, and Phosphoproteomics Reveal the Mechanism of Talaroconvolutin-A Suppressing Bladder Cancer via Blocking Cell Cycle and Triggering Ferroptosis
This study revealed that TalaA inhibited bladder cancer mainly by arresting cell cycle to suppress proliferation and triggering ferroptosis to cause cell death. Conclusively, TalaA would be a potential candidate for treating bladder cancer by targeting MAPKs, suppressing the cell cycle, and inducing ferroptosis.PMID:37866481 | DOI:10.1016/j.mcpro.2023.100672 (Source: Molecular and Cellular Proteomics : MCP)
Source: Molecular and Cellular Proteomics : MCP - October 22, 2023 Category: Molecular Biology Authors: Yong Xia Longquan Xiang Ming Yao Zhiying Ai Wei Yang Jianhua Guo Shuhao Fan Ning Liu Xiaolong Yang Source Type: research

Biochemical deconstruction and reconstruction of Nuclear Matrix reveals the layers of nuclear organization
Mol Cell Proteomics. 2023 Oct 18:100671. doi: 10.1016/j.mcpro.2023.100671. Online ahead of print.ABSTRACTNuclear Matrix (NuMat) is the fraction of the eukaryotic nucleus insoluble to detergents and high-salt extractions that manifests as a pan-nuclear fiber-granule network. NuMat consists of ribonucleoprotein complexes, members of crucial nuclear functional modules, and DNA fragments. Although NuMat captures the organization of non-chromatin nuclear space, very little is known about components organization within NuMat. To understand the organization of NuMat components, we subfractionated it with increasing concentrations...
Source: Molecular and Cellular Proteomics : MCP - October 20, 2023 Category: Molecular Biology Authors: Ashish Bihani Akshay K Avvaru Rakesh K Mishra Source Type: research