Molecular and Cellular Proteomics : MCP This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
High-throughput screening and proteomic characterization of compounds targeting myeloid-derived suppressor cells
Mol Cell Proteomics. 2023 Aug 14:100632. doi: 10.1016/j.mcpro.2023.100632. Online ahead of print.ABSTRACTMyeloid-derived suppressor cells (MDSC) are a heterogeneous cell population of incompletely differentiated immune cells. They are known to suppress T cell activity and are implicated in multiple chronic diseases, which makes them an attractive cell population for drug discovery. Here, we characterized the baseline proteomes and phospho-proteomes of mouse MDSC differentiated from a progenitor cell line to a depth of 7,000 proteins and phosphorylation sites. We also validated the cellular system for drug discovery by reca...
Source: Molecular and Cellular Proteomics : MCP - August 16, 2023 Category: Molecular Biology Authors: Johannes Krumm Elissaveta Petrova Severin Lechner Julia Mergner Hans-Henning Boehm Alessandro Prestipino Dominik Steinbrunn Marshall L Deline Lisa Koetzner Christina Schindler Laura Helming Tobias Fromme Martin Klingenspor Hannes Hahne Jan-Carsten Pieck B Source Type: research
High-throughput screening and proteomic characterization of compounds targeting myeloid-derived suppressor cells
Mol Cell Proteomics. 2023 Aug 14:100632. doi: 10.1016/j.mcpro.2023.100632. Online ahead of print.ABSTRACTMyeloid-derived suppressor cells (MDSC) are a heterogeneous cell population of incompletely differentiated immune cells. They are known to suppress T cell activity and are implicated in multiple chronic diseases, which makes them an attractive cell population for drug discovery. Here, we characterized the baseline proteomes and phospho-proteomes of mouse MDSC differentiated from a progenitor cell line to a depth of 7,000 proteins and phosphorylation sites. We also validated the cellular system for drug discovery by reca...
Source: Molecular and Cellular Proteomics : MCP - August 16, 2023 Category: Molecular Biology Authors: Johannes Krumm Elissaveta Petrova Severin Lechner Julia Mergner Hans-Henning Boehm Alessandro Prestipino Dominik Steinbrunn Marshall L Deline Lisa Koetzner Christina Schindler Laura Helming Tobias Fromme Martin Klingenspor Hannes Hahne Jan-Carsten Pieck B Source Type: research
What can Ribo-seq, immunopeptidomics, and proteomics tell us about the non-canonical proteome?
Mol Cell Proteomics. 2023 Aug 10:100631. doi: 10.1016/j.mcpro.2023.100631. Online ahead of print.ABSTRACTRibosome profiling (Ribo-seq) has proven transformative for our understanding of the human genome and proteome by illuminating thousands of non-canonical sites of ribosome translation outside of the currently annotated coding sequences (CDSs). A conservative estimate suggests that at least 7,000 non-canonical open reading frames (ORFs) are translated, which, at first glance, has the potential to expand the number of human protein-coding sequences by 30%, from ∼19,500 annotated CDSs to over 26,000. Yet, additional scru...
Source: Molecular and Cellular Proteomics : MCP - August 12, 2023 Category: Molecular Biology Authors: John R Prensner Jennifer G Abelin Leron W Kok Karl R Clauser Jonathan M Mudge Jorge Ruiz-Orera Michal Bassani-Sternberg Robert L Moritz Eric W Deutsch Sebastiaan van Heesch Source Type: research
What can Ribo-seq, immunopeptidomics, and proteomics tell us about the non-canonical proteome?
Mol Cell Proteomics. 2023 Aug 10:100631. doi: 10.1016/j.mcpro.2023.100631. Online ahead of print.ABSTRACTRibosome profiling (Ribo-seq) has proven transformative for our understanding of the human genome and proteome by illuminating thousands of non-canonical sites of ribosome translation outside of the currently annotated coding sequences (CDSs). A conservative estimate suggests that at least 7,000 non-canonical open reading frames (ORFs) are translated, which, at first glance, has the potential to expand the number of human protein-coding sequences by 30%, from ∼19,500 annotated CDSs to over 26,000. Yet, additional scru...
Source: Molecular and Cellular Proteomics : MCP - August 12, 2023 Category: Molecular Biology Authors: John R Prensner Jennifer G Abelin Leron W Kok Karl R Clauser Jonathan M Mudge Jorge Ruiz-Orera Michal Bassani-Sternberg Robert L Moritz Eric W Deutsch Sebastiaan van Heesch Source Type: research
What can Ribo-seq, immunopeptidomics, and proteomics tell us about the non-canonical proteome?
Mol Cell Proteomics. 2023 Aug 10:100631. doi: 10.1016/j.mcpro.2023.100631. Online ahead of print.ABSTRACTRibosome profiling (Ribo-seq) has proven transformative for our understanding of the human genome and proteome by illuminating thousands of non-canonical sites of ribosome translation outside of the currently annotated coding sequences (CDSs). A conservative estimate suggests that at least 7,000 non-canonical open reading frames (ORFs) are translated, which, at first glance, has the potential to expand the number of human protein-coding sequences by 30%, from ∼19,500 annotated CDSs to over 26,000. Yet, additional scru...
Source: Molecular and Cellular Proteomics : MCP - August 12, 2023 Category: Molecular Biology Authors: John R Prensner Jennifer G Abelin Leron W Kok Karl R Clauser Jonathan M Mudge Jorge Ruiz-Orera Michal Bassani-Sternberg Robert L Moritz Eric W Deutsch Sebastiaan van Heesch Source Type: research