Interactive use of online health resources: a comparison of consumer and professional questions
Conclusion Websites for consumers to submit health questions are a popular online resource filling important gaps in consumer health information. By analyzing how consumers write questions on these resources, we can better understand these gaps and create solutions for improving information access. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - May 4, 2016 Category: Information Technology Authors: Roberts, K., Demner-Fushman, D. Tags: Research and Applications Source Type: research

OpenFDA: an innovative platform providing access to a wealth of FDAs publicly available data
Conclusion With easier and faster access to these datasets, consumers worldwide can learn more about FDA-regulated products. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - May 2, 2016 Category: Information Technology Authors: Kass-Hout, T. A., Xu, Z., Mohebbi, M., Nelsen, H., Baker, A., Levine, J., Johanson, E., Bright, R. A. Tags: Research and Applications Source Type: research

The Medical Science DMZ
Conclusion By implementing a Medical Science DMZ architecture, biomedical researchers can leverage the scale provided by high-performance computer and cloud storage facilities and national high-speed research networks while preserving privacy and meeting regulatory requirements. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - May 2, 2016 Category: Information Technology Authors: Peisert, S., Barnett, W., Dart, E., Cuff, J., Grossman, R. L., Balas, E., Berman, A., Shankar, A., Tierney, B. Tags: Brief Communication Source Type: research

Will they participate? predicting patients response to clinical trial invitations in a pediatric emergency department
Conclusion By exploiting predictive variables from multiple sources, we demonstrated that machine learning algorithms have great potential in improving the effectiveness of the recruitment process by automatically predicting patients’ participation response to trial invitations. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 27, 2016 Category: Information Technology Authors: Ni, Y., Beck, A. F., Taylor, R., Dyas, J., Solti, I., Grupp-Phelan, J., Dexheimer, J. W. Tags: Research and Applications Source Type: research

Electronic medical record phenotyping using the anchor and learn framework
Conclusion Learning with anchors is an attractive option for building a large public repository of phenotype definitions that can be used for a range of health IT applications, including real-time decision support. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 27, 2016 Category: Information Technology Authors: Halpern, Y., Horng, S., Choi, Y., Sontag, D. Tags: Research and Applications Source Type: research

Development and implementation of a multitiered health informatics curriculum in a college of pharmacy
Standards requiring education in informatics in pharmacy curricula were introduced in the last 10 years by the Accreditation Council for Pharmacy Education. Mirroring difficulties faced by other health professions educators, implementation of these requirements remains fragmented and somewhat limited across colleges of pharmacy in the US. Clinical practice and workforce metrics underline a pronounced need for clinicians with varying competencies in health informatics. In response to these challenges, a multitiered health informatics curriculum was developed and implemented at a college of pharmacy in the Southeast. The mul...
Source: Journal of the American Medical Informatics Association - April 27, 2016 Category: Information Technology Authors: Breeden, E. A., Clauson, K. A. Tags: Perspective Source Type: research

Development and usage of wiki-based software for point-of-care emergency medical information
Objective To describe the creation and evaluate the usage of the first medical wiki linked to dedicated mobile applications.Methods With the support of multiple current and past contributors, we developed an emergency medicine wiki linked to offline mobile applications (WikEM) in 2009. First deployment was at the Harbor-UCLA Medical Center emergency medicine residency program, with the wiki later opened to public use. To evaluate the project, we performed a post hoc analysis of system use and surveyed 8 years of current and past residents. Outcomes included website and application analytics, as well as survey analysis by c...
Source: Journal of the American Medical Informatics Association - April 27, 2016 Category: Information Technology Authors: Donaldson, R. I., Ostermayer, D. G., Banuelos, R., Singh, M. Tags: Research and Applications Source Type: research

Text mining for precision medicine: automating disease-mutation relationship extraction from biomedical literature
Conclusions The proposed approach improves the state of the art for mutation-disease extraction from text. It is scalable and generalizable to identify mutations for any disease at a PubMed scale. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 27, 2016 Category: Information Technology Authors: Singhal, A., Simmons, M., Lu, Z. Tags: Research and Applications Source Type: research

Working title: Core informatics competencies for clinical and translational scientists: what do our customers and collaborators need to know?
Since the inception of the Clinical and Translational Science Award (CTSA) program in 2006, leaders in education across CTSA sites have been developing and updating core competencies for Clinical and Translational Science (CTS) trainees. By 2009, 14 competency domains, including biomedical informatics, had been identified and published. Since that time, the evolution of the CTSA program, changes in the practice of CTS, the rapid adoption of electronic health records (EHRs), the growth of biomedical informatics, the explosion of big data, and the realization that some of the competencies had proven to be difficult to apply ...
Source: Journal of the American Medical Informatics Association - April 27, 2016 Category: Information Technology Authors: Valenta, A. L., Meagher, E. A., Tachinardi, U., Starren, J. Tags: Perspective Source Type: research

Identifying visual search patterns in eye gaze data; gaining insights into physician visual workflow
Conclusions We evaluate and compare the visual search pattern results to first-order transition results. We discuss the benefits and limitations of this approach and insights from this initial evaluation. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Fong, A., Hoffman, D. J., Zachary Hettinger, A., Fairbanks, R. J., Bisantz, A. M. Tags: Brief Communication Source Type: research

An efficient approach for surveillance of childhood diabetes by type derived from electronic health record data: the SEARCH for Diabetes in Youth Study
Conclusion EHR data may be used to establish an efficient approach for large-scale surveillance for childhood diabetes by type, although some manual effort is still needed. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Zhong, V. W., Obeid, J. S., Craig, J. B., Pfaff, E. R., Thomas, J., Jaacks, L. M., Beavers, D. P., Carey, T. S., Lawrence, J. M., Dabelea, D., Hamman, R. F., Bowlby, D. A., Pihoker, C., Saydah, S. H., Mayer-Davis, E. J. Tags: Research and Applications Source Type: research

Development, Use, and Integration of a Nationally-Distributed HIV/AIDS Electronic Health Information System
Conclusion CAREWare has evolved significantly in functionality and use, including the capacity to run in a real-time network connecting multiple service providers, generate performance measures, and import data in multiple formats. The application is the source of over half of the Bureau s data, is used regularly by most providers and is installed in nearly every state. Ongoing enhancements will be essential to ensure that CAREWare stays current in a rapidly-changing environment of health information technology and data exchange. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Milberg, J. A. Tags: Brief Communication Source Type: research

An informatics research agenda to support precision medicine: seven key areas
The recent announcement of the Precision Medicine Initiative by President Obama has brought precision medicine (PM) to the forefront for healthcare providers, researchers, regulators, innovators, and funders alike. As technologies continue to evolve and datasets grow in magnitude, a strong computational infrastructure will be essential to realize PM’s vision of improved healthcare derived from personal data. In addition, informatics research and innovation affords a tremendous opportunity to drive the science underlying PM. The informatics community must lead the development of technologies and methodologies that wil...
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Tenenbaum, J. D., Avillach, P., Benham-Hutchins, M., Breitenstein, M. K., Crowgey, E. L., Hoffman, M. A., Jiang, X., Madhavan, S., Mattison, J. E., Nagarajan, R., Ray, B., Shin, D., Visweswaran, S., Zhao, Z., Freimuth, R. R. Tags: Perspective Source Type: research

A Bioinformatics approach for precision medicine Off-Label drug selection among triple negative breast cancer patients
Conclusions The proposed bioinformatics approach lays a foundation for cancer precision medicine. It supplies much needed knowledge base for the off-label cancer drug usage in clinics. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Cheng, L., Schneider, B. P., Li, L. Tags: Research and Applications Source Type: research

Applying probabilistic temporal and multisite data quality control methods to a public health mortality registry in Spain: a systematic approach to quality control of repositories
Conclusion Multisite and temporal variability in data distributions affects DQ, hindering data reuse, and an assessment of such variability should be a part of systematic DQ procedures. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Saez, C., Zurriaga, O., Perez-Panades, J., Melchor, I., Robles, M., Garcia-Gomez, J. M. Tags: Research and Applications Source Type: research

Electronic medical record phenotyping using the anchor and learn framework
Conclusion Learning with anchors is an attractive option for building a large public repository of phenotype definitions that can be used for a range of health IT applications, including real-time decision support. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Halpern, Y., Horng, S., Choi, Y., Sontag, D. Tags: Research and Applications Source Type: research

Public preferences for electronic health data storage, access, and sharing - evidence from a pan-European survey
Objective To assess the public’s preferences regarding potential privacy threats from devices or services storing health-related personal data.Materials and Methods A pan-European survey based on a stated-preference experiment for assessing preferences for electronic health data storage, access, and sharing.Results We obtained 20 882 survey responses (94 606 preferences) from 27 EU member countries. Respondents recognized the benefits of storing electronic health information, with 75.5%, 63.9%, and 58.9% agreeing that storage was important for improving treatment quality, preventing epidemics, and reducing delays, re...
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Patil, S., Lu, H., Saunders, C. L., Potoglou, D., Robinson, N. Tags: Research and Applications Source Type: research

Data quality of electronic medical records in Manitoba: do problem lists accurately reflect chronic disease billing diagnoses?
Conclusion This study demonstrates the high variability but generally low quality of problem lists (health condition records) related to 7 common chronic diseases in EMRs. There are systematic physician- and clinic-level factors associated with low data quality completeness. This information may be useful to support improvement in EMR data quality in primary care. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Singer, A., Yakubovich, S., Kroeker, A. L., Dufault, B., Duarte, R., Katz, A. Tags: Research and Applications Source Type: research

Quality improvement teams, super-users, and nurse champions: a recipe for meaningful use?
This study assessed whether having an electronic health record (EHR) super-user, nurse champion for meaningful use (MU), and quality improvement (QI) team leading MU implementation is positively associated with MU Stage 1 demonstration.Methods Data on MU demonstration of 596 providers in 37 ambulatory care clinics came from the clinical data warehouse and administrative systems of UNC Health Care. We surveyed the 37 clinics about champions, super-users, and QI teams. We used generalized estimating equation methods with an independence working correlation matrix to account for clustering within clinics and to weight contrib...
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Shea, C. M., Reiter, K. L., Weaver, M. A., Albritton, J. Tags: Brief Communication Source Type: research

Automated identification of molecular effects of drugs (AIMED)
Conclusions Precision medicine poses unique challenges for biomedical informatics systems that help domain experts find answers to their research questions. Further research is required to improve the performance of such systems, particularly for drugs in development. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Fathiamini, S., Johnson, A. M., Zeng, J., Araya, A., Holla, V., Bailey, A. M., Litzenburger, B. C., Sanchez, N. S., Khotskaya, Y., Xu, H., Meric-Bernstam, F., Bernstam, E. V., Cohen, T. Tags: Research and Applications Source Type: research

An in silico framework for integrating epidemiologic and genetic evidence with health care applications: ventilation-related pneumothorax as a case illustration
Conclusion Integration of complementary genetic evidence into epidemiologic analysis can lead to a cost- and time-efficient discovery of the risk predictors and markers and thus can facilitate more efficient marker-based evaluation of medical product performance. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Torosyan, Y., Hu, Y., Hoffman, S., Luo, Q., Carleton, B., Marinac-Dabic, D. Tags: Research and Applications Source Type: research

Ten key considerations for the successful optimization of large-scale health information technology
Implementation and adoption of complex health information technology (HIT) is gaining momentum internationally. This is underpinned by the drive to improve the safety, quality, and efficiency of care. Although most of the benefits associated with HIT will only be realized through optimization of these systems, relatively few health care organizations currently have the expertise or experience needed to undertake this. It is extremely important to have systems working before embarking on HIT optimization, which, much like implementation, is an ongoing, difficult, and often expensive process. We discuss some key organization...
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Cresswell, K. M., Bates, D. W., Sheikh, A. Tags: Perspective Source Type: research

Brief report: optimizing vitamin D naming conventions in computerized order entry to support high-value care
Objective To reduce wasteful ordering of rare 1,25-OH vitamin D lab tests through use of a noninterruptive decision support tool.Materials and Methods We conducted a time series quality improvement study at 2 academic hospitals. The titles of vitamin D tests and the order in which they appeared in search results were changed to reflect the purpose and rarity of the tests. We used interruptive time series analyses to evaluate the changes we made.Results The estimated number of monthly tests ordered at the 2 hospitals increased, by 24.8 and 14.2, following the introduction of computerized provider order entry (CPOE) (both P
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: White, A. A., McKinney, C. M., Hoffman, N. G., Sutton, P. R. Tags: Brief Communication Source Type: research

Testing electronic health records in the "production" environment: an essential step in the journey to a safe and effective health care system
Thorough and ongoing testing of electronic health records (EHRs) is key to ensuring their safety and effectiveness. Many health care organizations limit testing to test environments separate from, and often different than, the production environment used by clinicians. Because EHRs are complex hardware and software systems that often interact with other hardware and software systems, no test environment can exactly mimic how the production environment will behave. An effective testing process must integrate safely conducted testing in the production environment itself, using test patients. We propose recommendations for ho...
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Wright, A., Aaron, S., Sittig, D. F. Tags: Perspective Source Type: research

Health information exchange in the wild: the association between organizational capability and perceived utility of clinical event notifications in ambulatory and community care
Conclusions: Health care organizations with appropriate processes, workflows, and staff may be better positioned to use event notifications. Additionally, information quality remains critical in users’ assessments and perceptions. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Vest, J. R., Ancker, J. S. Tags: Research and Applications Source Type: research

The Pharmacist and the EHR
The adoption of electronic health records (EHRs) across the United States has impacted the methods by which health care professionals care for their patients. It is not always recognized, however, that pharmacists also actively use advanced functionality within the EHR. As critical members of the health care team, pharmacists utilize many different features of the EHR. The literature focuses on 3 main roles: documentation, medication reconciliation, and patient evaluation and monitoring. As health information technology proliferates, it is imperative that pharmacists’ workflow and information needs are met within the...
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Nelson, S. D., Poikonen, J., Reese, T., El Halta, D., Weir, C. Tags: Perspective Source Type: research

An appraisal of published usability evaluations of electronic health records via systematic review
Conclusion A review of the literature demonstrates a paucity of quality published studies describing scientifically valid and reproducible usability evaluations at various stages of EHR system development. A lack of formal and standardized reporting of EHR usability evaluation results is a major contributor to this knowledge gap, and efforts to improve this deficiency will be one step of moving the field of usability engineering forward. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Ellsworth, M. A., Dziadzko, M., OHoro, J. C., Farrell, A. M., Zhang, J., Herasevich, V. Tags: Review Source Type: research

Lower alert rates by clustering of related drug interaction alerts
Discussion and conclusion: Using clusters of drug interaction alerts with similar management recommendations in CDSSs can substantially decrease the overall alert rate. Further research is needed to establish the applicability of this concept in daily practice. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Heringa, M., Siderius, H., Floor-Schreudering, A., de Smet, P. A., Bouvy, M. L. Tags: Research and Applications Source Type: research

A national report of nursing home information technology: year 1 results
Conclusion Discovering national baseline assessments is a first step toward recognizing nursing home trends in IT adoption. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 23, 2016 Category: Information Technology Authors: Alexander, G. L., Madsen, R. W., Miller, E. L., Schaumberg, M. K., Holm, A. E., Alexander, R. L., Wise, K. K., Dougherty, M. L., Gugerty, B. Tags: Research and Applications Source Type: research

Developing a digital data collection platform to measure the prevalence of sepsis in Wales
Conclusion Our platform allowed us to measure, for the first time, the prevalence of sepsis in Wales over 24 hours. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 19, 2016 Category: Information Technology Authors: Sharif, B., Lundin, R., Morgan, P., Hall, J., Dhadda, A., Mann, C., Donoghue, D., Brownlow, E., Hill, F., Carr, G., Turley, H., Hassall, J., Atkinson, M., Jones, M., Martin, R., Rollason, S., Ibrahim, Y., Kopczynska, M., Szakmany, T. Tags: Brief Communication Source Type: research

Online HIV awareness and technology affordance benefits for black female collegians - maybe not: the case of stigma
Conclusions: Perceptions of stigma associated with HIV negatively impact health information seeking and sharing in the online social networks in which black college students engage. However, by understanding the unanticipated consequences, researchers can effectively design for cultures and subcultures infected and affected by health disparities. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 19, 2016 Category: Information Technology Authors: Payton, F. C., Kvasny, L. Tags: Research and Applications Source Type: research

Missing clinical and behavioral health data in a large electronic health record (EHR) system
Conclusion EHRs inadequately capture mental health diagnoses, visits, specialty care, hospitalizations, and medications. Missing clinical information raises concerns about medical errors and research integrity. Given the fragmentation of health care and poor EHR interoperability, information exchange, and usability, priorities for further investment in health IT will need thoughtful reconsideration. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - April 14, 2016 Category: Information Technology Authors: Madden, J. M., Lakoma, M. D., Rusinak, D., Lu, C. Y., Soumerai, S. B. Tags: Research and Applications Source Type: research

Developing new pathways into the biomedical informatics field: the AMIA High School Scholars Program
Increasing access to biomedical informatics experiences is a significant need as the field continues to face workforce challenges. Looking beyond traditional medical school and graduate school pathways into the field is crucial for expanding the number of individuals and increasing diversity in the field. This case report provides an overview of the development and initial implementation of the American Medical Informatics Association (AMIA) High School Scholars Program. Initiated in 2014, the program’s primary goal was to provide dissemination opportunities for high school students engaged in biomedical informatics ...
Source: Journal of the American Medical Informatics Association - April 13, 2016 Category: Information Technology Authors: Unertl, K. M., Finnell, J. T., Sarkar, I. N. Tags: Case Report Source Type: research

PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability
Conclusion By providing a central repository, PheKB enables improved development, transportability, and validity of algorithms for research-grade phenotypes using health care generated data. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - March 28, 2016 Category: Information Technology Authors: Kirby, J. C., Speltz, P., Rasmussen, L. V., Basford, M., Gottesman, O., Peissig, P. L., Pacheco, J. A., Tromp, G., Pathak, J., Carrell, D. S., Ellis, S. B., Lingren, T., Thompson, W. K., Savova, G., Haines, J., Roden, D. M., Harris, P. A., Denny, J. C. Tags: Research and Applications Source Type: research

Pragmatic Precision Oncology: The Secondary Uses of Clinical Tumor Molecular Profiling
Conclusions A real-time database of molecular profiling data is a pragmatic solution to several knowledge management problems in the practice and science of precision oncology. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - March 28, 2016 Category: Information Technology Authors: Rioth, M. J., Thota, R., Staggs, D. B., Johnson, D. B., Warner, J. L. Tags: Case Report Source Type: research

Analysis of clinical decision support system malfunctions: a case series and survey
Conclusion CDSS malfunctions occur commonly and often go undetected. Better methods are needed to prevent and detect these malfunctions. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - March 28, 2016 Category: Information Technology Authors: Wright, A., Hickman, T.-T. T., McEvoy, D., Aaron, S., Ai, A., Andersen, J. M., Hussain, S., Ramoni, R., Fiskio, J., Sittig, D. F., Bates, D. W. Tags: Research and Applications Source Type: research

Efficient identification of nationally mandated reportable cancer cases using natural language processing and machine learning
Conclusion CRCP demonstrates accurate results when applying natural language processing features to the problem of detecting patients with cases of reportable cancer from clinical notes. We show that implementing only a portion of cancer reporting rules in the form of regular expressions is sufficient to increase the precision, recall, and speed of the detection of reportable cancer cases when combined with off-the-shelf information extraction software and machine learning. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - March 28, 2016 Category: Information Technology Authors: Osborne, J. D., Wyatt, M., Westfall, A. O., Willig, J., Bethard, S., Gordon, G. Tags: Research and Applications Source Type: research

A network-based drug repositioning infrastructure for precision cancer medicine through targeting significantly mutated genes in the human cancer genomes
Objective Development of computational approaches and tools to effectively integrate multidomain data is urgently needed for the development of newly targeted cancer therapeutics.Methods We proposed an integrative network-based infrastructure to identify new druggable targets and anticancer indications for existing drugs through targeting significantly mutated genes (SMGs) discovered in the human cancer genomes. The underlying assumption is that a drug would have a high potential for anticancer indication if its up-/down-regulated genes from the Connectivity Map tended to be SMGs or their neighbors in the human protein int...
Source: Journal of the American Medical Informatics Association - March 28, 2016 Category: Information Technology Authors: Cheng, F., Zhao, J., Fooksa, M., Zhao, Z. Tags: Research and Applications Source Type: research

Discharge recommendation based on a novel technique of homeostatic analysis
Conclusion: Our results motivate the application of multidimensional analysis to other clinical problems and highlight the importance of risk factor trends and interdependencies in outcome prediction. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - March 28, 2016 Category: Information Technology Authors: Calvert, J. S., Price, D. A., Barton, C. W., Chettipally,, U. K., Das, R. Tags: Research and Applications Source Type: research

Toward a better understanding of task demands, workload, and performance during physician-computer interactions
Objective To assess the relationship between (1) task demands and workload, (2) task demands and performance, and (3) workload and performance, all during physician-computer interactions in a simulated environment.Methods Two experiments were performed in 2 different electronic medical record (EMR) environments: WebCIS (n = 12) and Epic (n = 17). Each participant was instructed to complete a set of prespecified tasks on 3 routine clinical EMR-based scenarios: urinary tract infection (UTI), pneumonia (PN), and heart failure (HF). Task demands were quantified using behavioral responses (click and time analysis). At the end o...
Source: Journal of the American Medical Informatics Association - March 28, 2016 Category: Information Technology Authors: Mazur, L. M., Mosaly, P. R., Moore, C., Comitz, E., Yu, F., Falchook, A. D., Eblan, M. J., Hoyle, L. M., Tracton, G., Chera, B. S., Marks, L. B. Tags: Research and Applications Source Type: research

IMPACT: a whole-exome sequencing analysis pipeline for integrating molecular profiles with actionable therapeutics in clinical samples
Conclusion IMPACT provides a new bioinformatics strategy to delineate candidate somatic variants and actionable therapies. This approach can be applied to other patient tumor samples to discover effective drug targets for personalized medicine.IMPACT is publicly available at http://tanlab.ucdenver.edu/IMPACT. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - March 28, 2016 Category: Information Technology Authors: Hintzsche, J., Kim, J., Yadav, V., Amato, C., Robinson, S. E., Seelenfreund, E., Shellman, Y., Wisell, J., Applegate, A., McCarter, M., Box, N., Tentler, J., De, S., Robinson, W. A., Tan, A. C. Tags: Research and Applications Source Type: research

Patients, care partners, and shared access to the patient portal: online practices at an integrated health system
Objective To describe the characteristics and online practices of patients and "care partners" who share explicit access to a patient portal account at a large integrated health system that implemented shared access functionality in 2003.Materials and Methods Survey of 323 patients and 389 care partners at Geisinger Health System with linked information regarding access and use of patient portal functionality.Results Few (0.4%) registered adult patient portal users shared access to their account. Patients varied in age (range: 18–102); more than half had a high school education or less (53.6%). Patient moti...
Source: Journal of the American Medical Informatics Association - March 28, 2016 Category: Information Technology Authors: Wolff, J. L., Berger, A., Clarke, D., Green, J. A., Stametz, R., Yule, C., Darer, J. D. Tags: Research and Applications Source Type: research

Enteric disease episodes and the risk of acquiring a future sexually transmitted infection: a prediction model in Montreal residents
Conclusion. The information produced from a prediction model capable of identifying higher risk individuals can be used to guide efforts in investigating and controlling reported cases of enteric diseases and STIs. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - March 28, 2016 Category: Information Technology Authors: Caron, M., Allard, R., Bedard, L., Latreille, J., Buckeridge, D. L. Tags: Research and Applications Source Type: research

Developing knowledge resources to support precision medicine: principles from the Clinical Pharmacogenetics Implementation Consortium (CPIC)
To move beyond a select few genes/drugs, the successful adoption of pharmacogenomics into routine clinical care requires a curated and machine-readable database of pharmacogenomic knowledge suitable for use in an electronic health record (EHR) with clinical decision support (CDS). Recognizing that EHR vendors do not yet provide a standard set of CDS functions for pharmacogenetics, the Clinical Pharmacogenetics Implementation Consortium (CPIC) Informatics Working Group is developing and systematically incorporating a set of EHR-agnostic implementation resources into all CPIC guidelines. These resources illustrate how to int...
Source: Journal of the American Medical Informatics Association - March 28, 2016 Category: Information Technology Authors: Hoffman, J. M., Dunnenberger, H. M., Kevin Hicks, J., Caudle, K. E., Whirl Carrillo, M., Freimuth, R. R., Williams, M. S., Klein, T. E., Peterson, J. F. Tags: Perspective Source Type: research

Automated integration of continuous glucose monitor data in the electronic health record using consumer technology
The diabetes healthcare provider plays a key role in interpreting blood glucose trends, but few institutions have successfully integrated patient home glucose data in the electronic health record (EHR). Published implementations to date have required custom interfaces, which limit wide-scale replication. We piloted automated integration of continuous glucose monitor data in the EHR using widely available consumer technology for 10 pediatric patients with insulin-dependent diabetes. Establishment of a passive data communication bridge via a patient’s/parent’s smartphone enabled automated integration and analytic...
Source: Journal of the American Medical Informatics Association - March 27, 2016 Category: Information Technology Authors: Kumar, R., Goren, N., Stark, D., Wall, D., Longhurst, C. Tags: Brief Communication Source Type: research

A proposed national research and development agenda for population health informatics: summary recommendations from a National Expert Workshop
Conclusion PopHI is a rapidly growing field that has emerged to address the population dimension of the Triple Aim. The proposed PopHI R&D agenda is comprehensive and timely, but should be considered only a starting-point, given that ongoing developments in health policy, population health management, and informatics are very dynamic, suggesting that the agenda will require constant monitoring and updating. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - March 27, 2016 Category: Information Technology Authors: Kharrazi, H., Lasser, E. C., Yasnoff, W. A., Loonsk, J., Advani, A., Lehmann, H. P., Chin, D. C., Weiner, J. P. Tags: Research and Applications Source Type: research

SMART precision cancer medicine: a FHIR-based app to provide genomic information at the point of care
Discussion PCM is open-source software for clinicians to present the individual patient within the population-level spectrum of cancer somatic mutations. The app can be implemented on any SMART on FHIR-enabled EHRs, and future versions of PCM should be able to evolve in parallel with external knowledge bases. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - March 27, 2016 Category: Information Technology Authors: Warner, J. L., Rioth, M. J., Mandl, K. D., Mandel, J. C., Kreda, D. A., Kohane, I. S., Carbone, D., Oreto, R., Wang, L., Zhu, S., Yao, H., Alterovitz, G. Tags: Research and Applications Source Type: research

Automated eligibility screening and monitoring for genotype-driven precision oncology trials
The Information Systems Department at Memorial Sloan Kettering Cancer Center developed the DARWIN Cohort Management System (DCMS). The DCMS identifies and tracks cohorts of patients based on genotypic and clinical data. It assists researchers and treating physicians in enrolling patients to genotype-matched IRB-approved clinical trials. The DCMS sends automated, actionable, and secure email notifications to users with information about eligible or enrolled patients before their upcoming appointments. The system also captures investigators input via annotations on patient eligibility and preferences on future status updates...
Source: Journal of the American Medical Informatics Association - March 25, 2016 Category: Information Technology Authors: Eubank, M. H., Hyman, D. M., Kanakamedala, A. D., Gardos, S. M., Wills, J. M., Stetson, P. D. Tags: Case Report Source Type: research

Preserving temporal relations in clinical data while maintaining privacy
Conclusions The method can be useful as a scientific approach for reducing re-identification risk under the Privacy Rule of the Health Insurance Portability and Accountability Act and may contribute to qualification for the Safe Harbor implementation. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - March 24, 2016 Category: Information Technology Authors: Hripcsak, G., Mirhaji, P., Low, A. F., Malin, B. A. Tags: Research and Applications Source Type: research

Extracting genetic alteration information for personalized cancer therapy from ClinicalTrials.gov
Discussion: The automated cancer treatment trial identification system achieved a high precision of 0.9944. Together with the manual review process, it identified 20 193 cancer treatment trials from ClinicalTrials.gov. The automated gene-alteration extraction system achieved a precision of 0.8300 and a recall of 0.6803. After validation by manual review, we generated a knowledge base of 2024 cancer trials that are labeled with specific genetic alteration information. Analysis of the knowledge base revealed the trend of increased use of targeted therapy for cancer, as well as top frequent gene-alteration pairs of interest. ...
Source: Journal of the American Medical Informatics Association - March 24, 2016 Category: Information Technology Authors: Xu, J., Lee, H.-J., Zeng, J., Wu, Y., Zhang, Y., Huang, L.-C., Johnson, A., Holla, V., Bailey, A. M., Cohen, T., Meric-Bernstam, F., Bernstam, E. V., Xu, H. Tags: Research and Applications Source Type: research