Phenotyping for patient safety: algorithm development for electronic health record based automated adverse event and medical error detection in neonatal intensive care.
CONCLUSIONS: Automated AE/ME detection algorithms provide higher sensitivity and PPV than currently used trigger tools or voluntary incident-reporting systems, including identification of potential dosing and frequency errors that current methods are unequipped to detect. PMID: 24401171 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - January 8, 2014 Category: Information Technology Authors: Li Q, Melton K, Lingren T, Kirkendall ES, Hall E, Zhai H, Ni Y, Kaiser M, Stoutenborough L, Solti I Tags: J Am Med Inform Assoc Source Type: research

Combining structured and unstructured data to identify a cohort of ICU patients who received dialysis.
CONCLUSIONS: Combining structured EHR data with information from clinical notes using simple queries increases the utility of both types of data for cohort identification. Patients identified by more than one source are more likely to meet the inclusion criteria; however, including patients found in any of the sources increases recall. This method is attractive because it is available to researchers with access to EHR data and off-the-shelf IR tools. PMID: 24384230 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - January 2, 2014 Category: Information Technology Authors: Abhyankar S, Demner-Fushman D, Callaghan FM, McDonald CJ Tags: J Am Med Inform Assoc Source Type: research

QNOTE: an instrument for measuring the quality of EHR clinical notes.
CONCLUSIONS: We found the QNOTE to be a valid instrument for evaluating the quality of electronic clinical notes, and its performance was superior to that of the Global instrument. PMID: 24384231 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - January 2, 2014 Category: Information Technology Authors: Burke HB, Hoang A, Becher D, Fontelo P, Liu F, Stephens M, Pangaro LN, Sessums LL, O'Malley P, Baxi NS, Bunt CW, Capaldi VF, Chen JM, Cooper BA, Djuric DA, Hodge JA, Kane S, Magee C, Makary ZR, Mallory RM, Miller T, Saperstein A, Servey J, Gimbel RW Tags: J Am Med Inform Assoc Source Type: research

The role of scientific publication in times of change.
PMID: 24335250 [PubMed - in process] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - December 18, 2013 Category: Information Technology Authors: Ohno-Machado L Tags: J Am Med Inform Assoc Source Type: research

Putting the 'i' in iHealth.
PMID: 24335251 [PubMed - in process] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - December 18, 2013 Category: Information Technology Authors: Middleton B, Fickenscher KM Tags: J Am Med Inform Assoc Source Type: research

Determining molecular predictors of adverse drug reactions with causality analysis based on structure learning.
CONCLUSIONS: The proposed CASTLE model not only performed better in prediction than the baseline SVM but also produced more interpretable results (ie, biological factors responsible for ADRs), which is critical to discovering molecular activators of ADRs. PMID: 24334612 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - December 11, 2013 Category: Information Technology Authors: Liu M, Cai R, Hu Y, Matheny ME, Sun J, Hu J, Xu H Tags: J Am Med Inform Assoc Source Type: research

Personal health records: a randomized trial of effects on elder medication safety.
CONCLUSIONS: PHRs can engage older adults for better medication self-management; however, features that motivate continued use will be needed. Longer-term studies of continued users will be required to evaluate the impact of these changes in behavior on patient health outcomes. PMID: 24326536 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - December 10, 2013 Category: Information Technology Authors: Chrischilles EA, Hourcade JP, Doucette W, Eichmann D, Gryzlak B, Lorentzen R, Wright K, Letuchy E, Mueller M, Farris K, Levy B Tags: J Am Med Inform Assoc Source Type: research

Electronic recording and reporting system for tuberculosis in China: experience and opportunities.
Abstract Tuberculosis (TB) surveillance in China is organized through a nationwide network of about 3200 hospitals and health facilities. In 2005, an electronic Tuberculosis Information Management System (TBIMS) started to be phased in to replace paper recording. The TBIMS collects key information on TB cases notified in TB care facilities, and exchanges real-time data with the Infectious Disease Reporting System, which covers the country's 37 notifiable diseases. The system is accessible to authorized users at every level of the TB network through a password-protected website. By 2009 the TBIMS achieved nationwid...
Source: Journal of the American Medical Informatics Association - December 10, 2013 Category: Information Technology Authors: Huang F, Cheng S, Du X, Chen W, Scano F, Falzon D, Wang L Tags: J Am Med Inform Assoc Source Type: research

Heart beats in the cloud: distributed analysis of electrophysiological 'big data' using cloud computing for epilepsy clinical research.
CONCLUSION: The Cloudwave platform is a new approach to leverage of large-scale electrophysiological data for advancing multicenter clinical research. PMID: 24326538 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - December 10, 2013 Category: Information Technology Authors: Sahoo SS, Jayapandian C, Garg G, Kaffashi F, Chung S, Bozorgi A, Chen CH, Loparo K, Lhatoo SD, Zhang GQ Tags: J Am Med Inform Assoc Source Type: research

Data governance requirements for distributed clinical research networks: triangulating perspectives of diverse stakeholders.
Abstract There is currently limited information on best practices for the development of governance requirements for distributed research networks (DRNs), an emerging model that promotes clinical data reuse and improves timeliness of comparative effectiveness research. Much of the existing information is based on a single type of stakeholder such as researchers or administrators. This paper reports on a triangulated approach to developing DRN data governance requirements based on a combination of policy analysis with experts, interviews with institutional leaders, and patient focus groups. This approach is illustr...
Source: Journal of the American Medical Informatics Association - December 3, 2013 Category: Information Technology Authors: Kim KK, Browe DK, Logan HC, Holm R, Hack L, Ohno-Machado L Tags: J Am Med Inform Assoc Source Type: research

Integrating pharmacogenetic information and clinical decision support into the electronic health record.
Abstract Pharmacogenetics (PG) examines gene variations for drug disposition, response, or toxicity. At the National Institutes of Health Clinical Center (NIH CC), a multidepartment Pharmacogenetics Testing Implementation Committee (PGTIC) was established to develop clinical decision support (CDS) algorithms for abacavir, carbamazepine, and allopurinol, medications for which human leukocyte antigen (HLA) variants predict severe hypersensitivity reactions. Providing PG CDS in the electronic health record (EHR) during order entry could prevent adverse drug events. Medical Logic Module (MLM) programming was used to i...
Source: Journal of the American Medical Informatics Association - December 3, 2013 Category: Information Technology Authors: Goldspiel BR, Flegel WA, Dipatrizio G, Sissung T, Adams SD, Penzak SR, Biesecker LG, Fleisher TA, Patel JJ, Herion D, Figg WD, Lertora JJ, McKeeby JW Tags: J Am Med Inform Assoc Source Type: research

Diagnosis code assignment: models and evaluation metrics.
CONCLUSIONS: Hierarchy-based classification yields better ICD9 coding than flat classification for MIMIC patients. Automated ICD9 coding is an example of a task for which data and tools can be shared and for which the research community can work together to build on shared models and advance the state of the art. PMID: 24296907 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - December 2, 2013 Category: Information Technology Authors: Perotte A, Pivovarov R, Natarajan K, Weiskopf N, Wood F, Elhadad N Tags: J Am Med Inform Assoc Source Type: research

N-CANDA data integration: anatomy of an asynchronous infrastructure for multi-site, multi-instrument longitudinal data capture.
Abstract The infrastructure for data collection implemented by the National Consortium on Alcohol and NeuroDevelopment in Adolescence (N-CANDA) for data collection comprises several innovative features: (a) secure, asynchronous transfer and persistent storage of collected data via a revision control system; (b) two-stage import into a longitudinal database; and (c) use of a script-controlled web browser for data retrieval from a third-party, web-based neuropsychological test battery. The asynchronous operation of data transmission and import is of particular benefit, as it has allowed the consortium sites to begin...
Source: Journal of the American Medical Informatics Association - December 2, 2013 Category: Information Technology Authors: Rohlfing T, Cummins K, Henthorn T, Chu W, Nichols BN Tags: J Am Med Inform Assoc Source Type: research

Preserving an integrated view of informatics.
PMID: 24287170 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - November 28, 2013 Category: Information Technology Authors: Bernstam EV, Tenenbaum JD, Kuperman GJ Tags: J Am Med Inform Assoc Source Type: research

Professional and geographical network effects on healthcare information exchange growth: does proximity really matter?
CONCLUSIONS: Flow of patients among different groups of physicians is a powerful factor in HIE adoption. Rather than merely following the market trend, physicians appear to be influenced by other physicians with whom they interact with and have common patients. PMID: 24287171 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - November 28, 2013 Category: Information Technology Authors: Yaraghi N, Du AY, Sharman R, Gopal RD, Ramesh R, Singh R, Singh G Tags: J Am Med Inform Assoc Source Type: research

Easily configured real-time CPOE Pick Off Tool supporting focused clinical research and quality improvement.
We describe a limited, order-entry-based, real-time 'pick off' tool, utilizing public domain software (PHP, MySQL). Through a web interface the tool assists users in constructing complex order-related queries and auto-generates corresponding database queries that can be executed at recurring intervals. We describe successful application of the tool for research and quality monitoring. PMID: 24287172 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - November 28, 2013 Category: Information Technology Authors: Rosenbaum BP, Silkin N, Miller RA Tags: J Am Med Inform Assoc Source Type: research

Exploiting the potential of large databases of electronic health records for research using rapid search algorithms and an intuitive query interface.
CONCLUSIONS: Our fast search algorithms and simple query algorithms represent a significant advance for users of clinical research databases. PMID: 24272162 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - November 22, 2013 Category: Information Technology Authors: Tate AR, Beloff N, Al-Radwan B, Wickson J, Puri S, Williams T, Van Staa T, Bleach A Tags: J Am Med Inform Assoc Source Type: research

Patient engagement in the inpatient setting: a systematic review.
CONCLUSIONS: Examination of the current literature shows there are considerable gaps in knowledge regarding patient engagement in the hospital setting and inconsistent use of terminology regarding patient engagement overall. Research on inpatient engagement technologies has been limited, especially concerning the impact on health outcomes and cost-effectiveness. PMID: 24272163 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - November 22, 2013 Category: Information Technology Authors: Prey JE, Woollen J, Wilcox L, Sackeim AD, Hripcsak G, Bakken S, Restaino S, Feiner S, Vawdrey DK Tags: J Am Med Inform Assoc Source Type: research

Learning classification models with soft-label information.
CONCLUSIONS: A new classification learning framework that lets us learn from auxiliary soft-label information provided by a human expert is a promising new direction for learning classification models from expert labels, reducing the time and cost needed to label data. PMID: 24259520 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - November 20, 2013 Category: Information Technology Authors: Nguyen Q, Valizadegan H, Hauskrecht M Tags: J Am Med Inform Assoc Source Type: research

Clinical decision support for atypical orders: detection and warning of atypical medication orders submitted to a computerized provider order entry system.
Abstract The specificity of medication-related alerts must be improved to overcome the pernicious effects of alert fatigue. A systematic comparison of new drug orders to historical orders could improve alert specificity and relevance. Using historical order data from a computerized provider order entry system, we alerted physicians to atypical orders during the prescribing of five medications: calcium, clopidogrel, heparin, magnesium, and potassium. The percentage of atypical orders placed for these five medications decreased during the 92 days the alerts were active when compared to the same period in the previou...
Source: Journal of the American Medical Informatics Association - November 19, 2013 Category: Information Technology Authors: Woods AD, Mulherin DP, Flynn AJ, Stevenson JG, Zimmerman CR, Chaffee BW Tags: J Am Med Inform Assoc Source Type: research

Using a medical simulation center as an electronic health record usability laboratory.
Abstract Usability testing is increasingly being recognized as a way to increase the usability and safety of health information technology (HIT). Medical simulation centers can serve as testing environments for HIT usability studies. We integrated the quality assurance version of our emergency department (ED) electronic health record (EHR) into our medical simulation center and piloted a clinical care scenario in which emergency medicine resident physicians evaluated a simulated ED patient and documented electronically using the ED EHR. Meticulous planning and close collaboration with expert simulation staff was i...
Source: Journal of the American Medical Informatics Association - November 18, 2013 Category: Information Technology Authors: Landman AB, Redden L, Neri P, Poole S, Horsky J, Raja AS, Pozner CN, Schiff G, Poon EG Tags: J Am Med Inform Assoc Source Type: research

ICD-10 codes used to identify adverse drug events in administrative data: a systematic review.
CONCLUSIONS: Substantial variability exists in the methods used to identify adverse drug events in administrative data. Our work may serve as a point of reference for future research and consensus building in this area. PMID: 24222671 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - November 12, 2013 Category: Information Technology Authors: Hohl CM, Karpov A, Reddekopp L, Stausberg J Tags: J Am Med Inform Assoc Source Type: research

Recent trends in biomedical informatics: a study based on JAMIA articles.
Abstract In a growing interdisciplinary field like biomedical informatics, information dissemination and citation trends are changing rapidly due to many factors. To understand these factors better, we analyzed the evolution of the number of articles per major biomedical informatics topic, download/online view frequencies, and citation patterns (using Web of Science) for articles published from 2009 to 2012 in JAMIA. The number of articles published in JAMIA increased significantly from 2009 to 2012, and there were some topic differences in the last 4 years. Medical Record Systems, Algorithms, and Methods are topi...
Source: Journal of the American Medical Informatics Association - November 8, 2013 Category: Information Technology Authors: Jiang X, Tse K, Wang S, Doan S, Kim H, Ohno-Machado L Tags: J Am Med Inform Assoc Source Type: research

Automated identification of patients with a diagnosis of binge eating disorder from narrative electronic health records.
Abstract Binge eating disorder (BED) does not have an International Classification of Diseases, 9th or 10th edition code, but is included under 'eating disorder not otherwise specified' (EDNOS). This historical cohort study identified patients with clinician-diagnosed BED from electronic health records (EHR) in the Department of Veterans Affairs between 2000 and 2011 using natural language processing (NLP) and compared their characteristics to patients identified by EDNOS diagnosis codes. NLP identified 1487 BED patients with classification accuracy of 91.8% and sensitivity of 96.2% compared to human review. After...
Source: Journal of the American Medical Informatics Association - November 7, 2013 Category: Information Technology Authors: Bellows BK, Lafleur J, Kamauu AW, Ginter T, Forbush TB, Agbor S, Supina D, Hodgkins P, Duvall SL Tags: J Am Med Inform Assoc Source Type: research

A review of approaches to identifying patient phenotype cohorts using electronic health records.
CONCLUSIONS: There are a variety of approaches for classifying patients into a particular phenotype. Different techniques and data sources are used, and good performance is reported on datasets at respective institutions. However, no system makes comprehensive use of electronic medical records addressing all of their known weaknesses. PMID: 24201027 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - November 7, 2013 Category: Information Technology Authors: Shivade C, Raghavan P, Fosler-Lussier E, Embi PJ, Elhadad N, Johnson SB, Lai AM Tags: J Am Med Inform Assoc Source Type: research

Privacy preserving interactive record linkage (PPIRL).
CONCLUSIONS: Human-based third-party linkage centers for privacy preserving record linkage are the accepted norm internationally. We find that a computer-based third-party platform that can precisely control the information disclosed at the micro level and allow frequent human interaction during the linkage process, is an effective human-machine hybrid system that significantly improves on the linkage center model both in terms of privacy and utility. PMID: 24201028 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - November 7, 2013 Category: Information Technology Authors: Kum HC, Krishnamurthy A, Machanavajjhala A, Reiter MK, Ahalt S Tags: J Am Med Inform Assoc Source Type: research

Formalization and computation of quality measures based on electronic medical records.
CONCLUSIONS: The CLIF method covers all quality measures after having been extended by an additional step. Our web tool requires further refinement for CLIF to be applied completely automatically. We therefore conclude that CLIF is sufficiently generalizable to be able to formalize the entire set of Dutch quality measures for general practice. PMID: 24192317 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - November 5, 2013 Category: Information Technology Authors: Dentler K, Numans ME, Ten Teije A, Cornet R, de Keizer NF Tags: J Am Med Inform Assoc Source Type: research

Normalization and standardization of electronic health records for high-throughput phenotyping: the SHARPn consortium.
DB, Tao C, Taylor DP, Westberg L, Wu S, Zhuo N, Chute CG Abstract RESEARCH OBJECTIVE: To develop scalable informatics infrastructure for normalization of both structured and unstructured electronic health record (EHR) data into a unified, concept-based model for high-throughput phenotype extraction. MATERIALS AND METHODS: Software tools and applications were developed to extract information from EHRs. Representative and convenience samples of both structured and unstructured data from two EHR systems-Mayo Clinic and Intermountain Healthcare-were used for development and validation. Extracted information was s...
Source: Journal of the American Medical Informatics Association - November 4, 2013 Category: Information Technology Authors: Pathak J, Bailey KR, Beebe CE, Bethard S, Carrell DC, Chen PJ, Dligach D, Endle CM, Hart LA, Haug PJ, Huff SM, Kaggal VC, Li D, Liu H, Marchant K, Masanz J, Miller T, Oniki TA, Palmer M, Peterson KJ, Rea S, Savova GK, Stancl CR, Sohn S, Solbrig HR, Suesse Tags: J Am Med Inform Assoc Source Type: research

National evaluation of the benefits and risks of greater structuring and coding of the electronic health record: exploratory qualitative investigation.
CONCLUSIONS: The design and development of EHRs requires the capture of narrative information to reflect patient/clinician communication and computable data for administration and research purposes. Increased structuring and/or coding of EHRs therefore offers both benefits and risks. Documentation standards within clinical guidelines are likely to encourage comprehensive, accurate processing of data. As data structures may impact upon clinician/patient interactions, new models of documentation may be necessary if EHRs are to be read and authored by patients. PMID: 24186957 [PubMed - as supplied by publisher] (Source: ...
Source: Journal of the American Medical Informatics Association - November 1, 2013 Category: Information Technology Authors: Morrison Z, Fernando B, Kalra D, Cresswell K, Sheikh A Tags: J Am Med Inform Assoc Source Type: research

Exposome informatics: considerations for the design of future biomedical research information systems.
This article analyzes the implications of a new paradigm for the discipline of BMI, one that recognizes genome, phenome, and exposome data and their intricate interactions as the basis for biomedical research now and for clinical care in the near future. PMID: 24186958 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - November 1, 2013 Category: Information Technology Authors: Martin Sanchez F, Gray K, Bellazzi R, Lopez-Campos G Tags: J Am Med Inform Assoc Source Type: research

Data science and informatics: when it comes to biomedical data, is there a real distinction?
PMID: 24114329 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - October 14, 2013 Category: Information Technology Authors: Ohno-Machado L Tags: J Am Med Inform Assoc Source Type: research

Biomedical imaging informatics in the era of precision medicine: progress, challenges, and opportunities.
PMID: 24114330 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - October 14, 2013 Category: Information Technology Authors: Hsu W, Markey MK, Wang MD Tags: J Am Med Inform Assoc Source Type: research

President's column: the community imperative--Share to Care and Cure.
PMID: 24114331 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - October 14, 2013 Category: Information Technology Authors: Fickenscher KM Tags: J Am Med Inform Assoc Source Type: research

Database queries for hospitalizations for acute congestive heart failure: flexible methods and validation based on set theory.
Abstract BACKGROUND AND OBJECTIVE: Electronic health records databases are increasingly used for identifying cohort populations, covariates, or outcomes, but discerning such clinical 'phenotypes' accurately is an ongoing challenge. We developed a flexible method using overlapping (Venn diagram) queries. Here we describe this approach to find patients hospitalized with acute congestive heart failure (CHF), a sampling strategy for one-by-one 'gold standard' chart review, and calculation of positive predictive value (PPV) and sensitivities, with SEs, across different definitions. MATERIALS AND METHODS: We used r...
Source: Journal of the American Medical Informatics Association - October 10, 2013 Category: Information Technology Authors: Rosenman M, He J, Martin J, Nutakki K, Eckert G, Lane K, Gradus-Pizlo I, Hui SL Tags: J Am Med Inform Assoc Source Type: research

Call for discussion about the framework for categorizing economic evaluations of health information systems and assessing their quality.
PMID: 24107460 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - October 9, 2013 Category: Information Technology Authors: Gospodarevskaya E, Westbrook JI Tags: J Am Med Inform Assoc Source Type: research

The effect of word familiarity on actual and perceived text difficulty.
Abstract There is little evidence that readability formula outcomes relate to text understanding. The potential cause may lie in their strong reliance on word and sentence length. We evaluated word familiarity rather than word length as a stand-in for word difficulty. Word familiarity represents how well known a word is, and is estimated using word frequency in a large text corpus, in this work the Google web corpus. We conducted a study with 239 people, who provided 50 evaluations for each of 275 words. Our study is the first study to focus on actual difficulty, measured with a multiple-choice task, in addition t...
Source: Journal of the American Medical Informatics Association - October 7, 2013 Category: Information Technology Authors: Leroy G, Kauchak D Tags: J Am Med Inform Assoc Source Type: research

Using electronic health record data to develop inpatient mortality predictive model: Acute Laboratory Risk of Mortality Score (ALaRMS).
CONCLUSIONS: EHR data can generate clinically plausible mortality predictive models with excellent discrimination. ALaRMS uses automated laboratory data widely available on admission, providing opportunities to aid real-time decision support. Models that incorporate laboratory and AHRQ's CCS and CS variables have utility for risk adjustment in retrospective outcome studies. PMID: 24097807 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - October 4, 2013 Category: Information Technology Authors: Tabak YP, Sun X, Nunez CM, Johannes RS Tags: J Am Med Inform Assoc Source Type: research

Discovering body site and severity modifiers in clinical texts.
CONCLUSIONS: We investigated computational methods for discovering body site and severity modifiers in clinical texts. Our best system is released open source as part of the clinical Text Analysis and Knowledge Extraction System (cTAKES). PMID: 24091648 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - October 3, 2013 Category: Information Technology Authors: Dligach D, Bethard S, Becker L, Miller T, Savova GK Tags: J Am Med Inform Assoc Source Type: research

Content and functional specifications for a standards-based multidisciplinary rounding tool to maintain continuity across acute and critical care.
CONCLUSIONS: We recommend an initial list of 11 universal CDEs for continuity in MDRs across settings and 27 CDEs that can be configured to meet setting-specific needs. PMID: 24081019 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 30, 2013 Category: Information Technology Authors: Collins S, Hurley AC, Chang FY, Illa AR, Benoit A, Laperle S, Dykes PC Tags: J Am Med Inform Assoc Source Type: research

A sea of standards for omics data: sink or swim?
Abstract In the era of big data, omic-scale technologies, and increasing calls for data sharing, it is generally agreed that the use of community-developed, open data standards is critical. Far less agreed upon is exactly which data standards should be used, the criteria by which one should choose a standard, or even what constitutes a data standard. It is impossible simply to choose a domain and have it naturally follow which data standards should be used in all cases. The 'right' standards to use is often dependent on the use case scenarios for a given project. Potential downstream applications for the data, how...
Source: Journal of the American Medical Informatics Association - September 27, 2013 Category: Information Technology Authors: Tenenbaum JD, Sansone SA, Haendel M Tags: J Am Med Inform Assoc Source Type: research

Mining high-dimensional administrative claims data to predict early hospital readmissions.
Abstract BACKGROUND: Current readmission models use administrative data supplemented with clinical information. However, the majority of these result in poor predictive performance (area under the curve (AUC)
Source: Journal of the American Medical Informatics Association - September 27, 2013 Category: Information Technology Authors: He D, Mathews SC, Kalloo AN, Hutfless S Tags: J Am Med Inform Assoc Source Type: research

Sharing behavioral data through a grid infrastructure using data standards.
CONCLUSIONS: Behavioral and population science data can be standardized by using and extending current standards. A new branch of CDE for behavioral science was developed for the caDSR. It expands the caDSR domain coverage beyond the clinical and biological areas. In addition, missing terms and concepts specific to the behavioral measures addressed in this paper were added to the NCI thesaurus. A methodology was developed and refined for curation of behavioral and population science data. PMID: 24076749 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 27, 2013 Category: Information Technology Authors: Min H, Ohira R, Collins MA, Bondy J, Avis NE, Tchuvatkina O, Courtney PK, Moser RP, Shaikh AR, Hesse BW, Cooper M, Reeves D, Lanese B, Helba C, Miller SM, Ross EA Tags: J Am Med Inform Assoc Source Type: research

Supervised embedding of textual predictors with applications in clinical diagnostics for pediatric cardiology.
CONCLUSIONS: As a solution, we present a supervised Laplacian Eigenmap method to embed textual predictors into a low-dimensional Euclidean space. This method allows many existing machine learning predictors to effectively and efficiently capture the potential of textual predictors, especially those based on short texts. PMID: 24076750 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 27, 2013 Category: Information Technology Authors: Perry TE, Zha H, Zhou K, Frias P, Zeng D, Braunstein M Tags: J Am Med Inform Assoc Source Type: research

An informatics approach to medication adherence assessment and improvement using clinical, billing, and patient-entered data.
Abstract The aim of this study was to describe an integrated informatics approach to aggregating and displaying clinically relevant data that can identify problems with medication adherence and facilitate patient-provider communication about strategies to improve medication use. We developed a clinical dashboard within an electronic health record (EHR) system that uses data from three sources: the medical record, pharmacy claims, and a personal health record. The data are integrated to inform clinician-patient discussions about medication adherence. Whereas prior research on assessing patterns of medication adhere...
Source: Journal of the American Medical Informatics Association - September 27, 2013 Category: Information Technology Authors: Dixon BE, Jabour AM, Phillips EO, Marrero DG Tags: J Am Med Inform Assoc Source Type: research

An adaptable architecture for patient cohort identification from diverse data sources.
CONCLUSIONS: The architecture has been used to implement a specific query model that can express complex eligibility criteria and access three diverse data warehouses thus demonstrating the feasibility of this approach in dealing with temporal reasoning and data heterogeneity. PMID: 24064442 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 24, 2013 Category: Information Technology Authors: Bache R, Miles S, Taweel A Tags: J Am Med Inform Assoc Source Type: research

Sociotechnical challenges to developing technologies for patient access to health information exchange data.
CONCLUSIONS: This prospective study revealed how sociotechnical factors previously identified as important in health information technology success and failure helped to shape the evolution of three novel consumer informatics projects. Barriers to providing patients with seamless access to their HIE data were multifactorial. Remedies will have to address technical, organizational, cultural, and other factors. PMID: 24064443 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 24, 2013 Category: Information Technology Authors: Ancker JS, Miller MC, Patel V, Kaushal R, with the HITEC Investigators Tags: J Am Med Inform Assoc Source Type: research

Classification of medication incidents associated with information technology.
CONCLUSIONS: A large sample of incidents shows that many of the incidents are related to IT, both in community pharmacies and hospitals. The interaction between human and machine plays a pivotal role in IT incidents in both settings. PMID: 24064444 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 24, 2013 Category: Information Technology Authors: Cheung KC, van der Veen W, Bouvy ML, Wensing M, van den Bemt PM, de Smet PA Tags: J Am Med Inform Assoc Source Type: research

Exploring the sociotechnical intersection of patient safety and electronic health record implementation.
CONCLUSIONS: Using sociotechnical models, including those presented in this paper, may be beneficial to help stakeholders understand, synthesize, and anticipate risks at the intersection of patient safety and health information technology. PMID: 24052536 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 19, 2013 Category: Information Technology Authors: Meeks DW, Takian A, Sittig DF, Singh H, Barber N Tags: J Am Med Inform Assoc Source Type: research

Predicting changes in hypertension control using electronic health records from a chronic disease management program.
CONCLUSIONS: This study achieved accurate prediction of transition points of hypertension control status, an important first step in the long-term goal of developing personalized hypertension management plans. PMID: 24045907 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 17, 2013 Category: Information Technology Authors: Sun J, McNaughton CD, Zhang P, Perer A, Gkoulalas-Divanis A, Denny JC, Kirby J, Lasko T, Saip A, Malin BA Tags: J Am Med Inform Assoc Source Type: research

Medical decision support using machine learning for early detection of late-onset neonatal sepsis.
CONCLUSIONS: Predictive models developed from off-the-shelf and EMR data using ML algorithms exceeded the treatment sensitivity and treatment specificity of clinicians. A prospective study is warranted to assess the clinical utility of the ML algorithms in improving the accuracy of antibiotic use in the management of neonatal sepsis. PMID: 24043317 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 16, 2013 Category: Information Technology Authors: Mani S, Ozdas A, Aliferis C, Varol HA, Chen Q, Carnevale R, Chen Y, Romano-Keeler J, Nian H, Weitkamp JH Tags: J Am Med Inform Assoc Source Type: research