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Computational drug repositioning of atorvastatin for ulcerative colitis
ConclusionThese findings suggest that atorvastatin may serve as a novel therapeutic option for ameliorating disease in patients with UC. Importantly, we provide a systematic framework for integrating publicly available heterogeneous molecular data with clinical data at a large scale to repurpose existing FDA-approved drugs for a wide range of human diseases. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 16, 2021 Category: Information Technology Source Type: research

Distantly supervised biomedical relation extraction using piecewise attentive convolutional neural network and reinforcement learning
ConclusionsThe performance on many distantly supervised biomedical RE tasks was substantially improved, primarily owing to the denoising effect of the proposed model. It is anticipated that PACNN+RL will become a useful tool for large-scale RE and other downstream tasks to facilitate biomedical knowledge acquisition. We also made the demonstration program and source code publicly available athttp://112.74.48.115:9000/. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 15, 2021 Category: Information Technology Source Type: research

Characterizing phenotypic abnormalities associated with high-risk individuals developing lung cancer using electronic health records from the All of Us researcher workbench
ConclusionsIt is feasible to conduct a phenome-wide association study to characterize phenotypic abnormalities associated in high-risk individuals developing lung cancer using electronic health records. TheAll of Us Research Workbench is a promising resource for the research studies to evaluate and optimize lung cancer screening criteria. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 10, 2021 Category: Information Technology Source Type: research

Automation in nursing decision support systems: A systematic review of effects on decision making, care delivery, and patient outcomes
ConclusionsCurrent nursing DSSs do not adequately support the NCP and have limited automation. There remain many opportunities to enhance automation, especially at the stage of information acquisition. Further research is needed to understand how automation within the NCP can improve nurses ’ decision making, care delivery, and patient outcomes. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 8, 2021 Category: Information Technology Source Type: research

Looking for clinician involvement under the wrong lamp post: The need for collaboration measures
Duke Health10.13039/100016652 (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 8, 2021 Category: Information Technology Source Type: research

Response to: Looking for clinician involvement under the wrong lamp post: the need for collaboration measures
National Library of Medicine10.13039/1000000925T15LM007079National Institute for Nursing Research (NINR)5T32NR007969 (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 8, 2021 Category: Information Technology Source Type: research

Mining relationships between transmission clusters from contact tracing data: An application for investigating COVID-19 outbreak
ConclusionsThe proposed algorithm could contribute to in-depth epidemiologic investigation of infectious disease transmission to support targeted nonpharmaceutical intervention policies for COVID-19 epidemic control. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 8, 2021 Category: Information Technology Source Type: research

Transgender data collection in the electronic health record: Current concepts and issues
We present recommendations and common pitfalls involving sex- and gender-related data collection in EHRs. Our recommendations leverage the needs of patients, medical providers, and researchers to optimize both individual patient experiences and the efficacy and reproducibility of EHR population-based studies. We also briefly discuss adequate additions to the EHR considering name and pronoun usage. We add the disclaimer that these questions are more complex than commonly assumed. We conclude that collaborations between local transgender and gender-diverse persons and medical providers as well as open inclusion of transgende...
Source: Journal of the American Medical Informatics Association - September 6, 2021 Category: Information Technology Source Type: research

The ecosystem of apps and software integrated with certified health information technology
ConclusionIt is a federal government priority to improve the access and use of electronic health information, including third-party apps that can introduce competition as well as best-of-breed functions and user experiences. This study shows that there is room for growth, and variation exists among some of the largest EHR developers. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 6, 2021 Category: Information Technology Source Type: research

Call for emergency action to limit global temperature increases, restore biodiversity, and protect healthWealthy nations must do much more, much faster †
The UN General Assembly in September 2021 will bring countries together at a critical time for marshaling collective action to tackle the global environmental crisis. They will meet again at the biodiversity summit in Kunming, China, and the climate conference (COP26) in Glasgow, UK. Ahead of these pivotal meetings, we —the editors of health journals worldwide—call for urgent action to keep average global temperature increases below 1.5°C, halt the destruction of nature, and protect health. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 6, 2021 Category: Information Technology Source Type: research

Interactive, on-line visualization tools to measure and drive equity in COVID-19 vaccine administrations
AbstractEquitable distribution of vaccines is necessary to ensure those at highest risk of illness are protected from COVID-19. Unfortunately, there is significant evidence that vaccines have not been reaching the most vulnerable. At our large hospital system, we created interactive on-line tools to measure and visualize equitability of vaccine administrations and to help stakeholders identify populations at highest risk within state designated eligible vaccine groups. Using race, ethnicity, gender, and social vulnerability, we are able to measure and reflect our vaccine administration performance against the communities t...
Source: Journal of the American Medical Informatics Association - September 4, 2021 Category: Information Technology Source Type: research

Operationalizing and analyzing 2-step gender identity questions: Methodological and ethical considerations
ConclusionsThe field of clinical informatics has an opportunity to incorporate inclusive items like the 2-step gender identity question into electronic health records to optimize care and strengthen clinical research. Analysis of the 2-step gender identity question impacts study results and interpretation. Attention to how data about GDY are captured will support for more nuanced, tailored analyses that better reflect unique experiences within this population. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 2, 2021 Category: Information Technology Source Type: research

Expected clinical utility of automatable prediction models for improving palliative and end-of-life care outcomes: Toward routine decision analysis before implementation
ConclusionsAn evaluation of clinical utility, such as by using decision curve analysis, is recommended after validating a prediction model because metrics of model predictiveness, such as the C-statistic, are not informative of clinical value. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 2, 2021 Category: Information Technology Source Type: research

Mobile health applications for older adults: a systematic review of interface and persuasive feature design
ConclusionsThis review synthesizes elderly-friendly interface and persuasive feature design recommendations for mobile health applications from the existing literature and provides recommendations for future research in this area and guidelines for designers. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 2, 2021 Category: Information Technology Source Type: research

GraphSynergy: a network-inspired deep learning model for anticancer drug combination prediction
ConclusionThe introduction of topological relations between drug combination and cell line within the PPI network can significantly improve the capability of synergistic drug combination identification. (Source: Journal of the American Medical Informatics Association)
Source: Journal of the American Medical Informatics Association - September 2, 2021 Category: Information Technology Source Type: research