Journal of Southern Medical University This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Activation of < em > α < /em > 7 nAChR improves white fat homeostasis and promotes beige adipogenesis and thermogenesis in obese mice
CONCLUSION: Activation of α7 nAchR improves white adipose tissue homeostasis impairment induced by β3 agonist, promotes transformation of M1 to M2 macrophages, reduces inflammatory response in white adipose tissue, and promote beige adipogenesis and thermogenesis in obese mice.PMID:38597441 | PMC:PMC11006706 | DOI:10.12122/j.issn.1673-4254.2024.03.11 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: H Bao S Wang M L ü Y Wang P Jiang X Li Source Type: research

HTD4010 attenuates myocardial injury in mice with septic cardiomyopathy by promoting autophagy < em > via < /em > the AMPK/mTOR signaling pathway
CONCLUSION: HTD4010 can attenuate myocardial injury in SCM mice possibly by promoting autophagy via modulating the AMPK/mTOR signaling pathway.PMID:38597442 | PMC:PMC11006686 | DOI:10.12122/j.issn.1673-4254.2024.03.12 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: H Xiao B Han J Guo C Wu J Wu Source Type: research

Saikosaponin a alleviates pentylenetetrazol-induced acute epileptic seizures in mouse models of depression by suppressing microglia activation-mediated inflammation
CONCLUSION: Depressive state aggravates epileptic seizures, increases microglia activation, and elevates inflammation levels. SSA treatment can alleviate acute epileptic seizures in mouse models of depression possibly by suppressing microglia activation-mediated inflammation.PMID:38597443 | PMC:PMC11006703 | DOI:10.12122/j.issn.1673-4254.2024.03.13 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Y Xiong X Liang X Liang W Li Y Qian W Xie Source Type: research

Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats
CONCLUSION: Asiaticoside induces thoracic aorta relaxation by mediating high-conductance calcium-activated potassium channel opening, promoting nitric oxide release from endothelial cells and regulating Ca2+ influx and outflow, thereby reducing systolic blood pressure in rats.PMID:38597444 | PMC:PMC11006695 | DOI:10.12122/j.issn.1673-4254.2024.03.14 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: G Lu H Sun Z Sun L Liu L Wang N Zhang Y Wang Y He J Ji X Li P Kang B Tang Source Type: research

A sericin hydrogel scaffold for sustained dexamethasone release modulates macrophage polarization to promote mandibular bone defect repair in rats
CONCLUSION: The SMH-CD/DEX scaffold capable of sustained dexamethasone release promotes osteogenic differentiation of stem cells and bone defect repair in rats by regulating M2 polarization.PMID:38597445 | PMC:PMC11006699 | DOI:10.12122/j.issn.1673-4254.2024.03.15 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Y Fan M Luo D Huang L Liu B Fu X Wang M Guan H Li Source Type: research

High LINC00626 expression promotes esophagogastric junction adenocarcinoma metastasis: the mediating role of the JAK1/STAT3/KHSRP axis
CONCLUSION: High LINC00626 expression promotes esophageal-gastric junction adenocarcinoma metastasis by activating the JAK1/STAT3/KHSRP signal axis.PMID:38597446 | PMC:PMC11006707 | DOI:10.12122/j.issn.1673-4254.2024.03.16 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: F Zhang L Fan X Kang H Wei L Li Source Type: research

Predictive value of cardiac magnetic resonance imaging for adverse left ventricular remodeling after acute ST-segment elevation myocardial infarction
CONCLUSION: The extent of infarct mass, peak radial diastolic strain rate, and RAAS inhibitor are independent predictors of adverse LV remodeling following STEMI.PMID:38597447 | PMC:PMC11006702 | DOI:10.12122/j.issn.1673-4254.2024.03.17 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Cui W Liu F Yan Y Zhao W Chen C Luo X Zhang T Li Source Type: research

PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMK Ⅱγ and CaMKⅡδ against ischemic reperfusion injury in mice
CONCLUSION: The neuroprotective effects of CaMKⅡδ and CaMKⅡγ against acute neuronal ischemic reperfusion injury are mediated probably by the PI3K/Akt/Erk pathway.PMID:38597448 | PMC:PMC11006692 | DOI:10.12122/j.issn.1673-4254.2024.03.18 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: H Liu Z Lin J Ye Source Type: research

MiR-132-3p negatively regulates CAMTA1 to promote Schwann cell proliferation and migration and alleviates I-125 seeds-induced exacerbation of facial nerve injury in rats
CONCLUSION: Overexpression of miR-132-3p suppresses CAMTA1 expression and promotes Schwann cell proliferation and migration to alleviate I-125 seeds-induced exacerbation of FNI in rats.PMID:38597449 | PMC:PMC11006691 | DOI:10.12122/j.issn.1673-4254.2024.03.19 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Zhu X Ouyang Y Liu Y Qian B Xia Y Shi L Yu Source Type: research

MiR-26-3p regulates proliferation, migration, invasion and apoptosis of glioma cells by targeting CREB1
CONCLUSION: MiR-26b-3p regulates CREB1 expression to modulate apoptosis, proliferation, migration and invasion of glioma cells, thereby participating in tumorigenesis and progression of glioma.PMID:38597450 | PMC:PMC11006701 | DOI:10.12122/j.issn.1673-4254.2024.03.20 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Q Huang J Zhou Z Wang K Yang Z Chen Source Type: research

Automatic classification of immune-mediated glomerular diseases based on multi-modal multi-instance learning
CONCLUSION: This multi- modal multi- instance model based on OM, IM, and TEM images can achieve automatic classification of immune-mediated glomerular diseases with a good classification accuracy.PMID:38597451 | PMC:PMC11006708 | DOI:10.12122/j.issn.1673-4254.2024.03.21 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: K Long D Weng J Geng Y Lu Z Zhou L Cao Source Type: research

Single extract of Forsythia Suspense versus the prepared drug in pieces: comparison of their anti-inflammatory, antitumor and antibacterial effects in zebrafish
CONCLUSION: The two dosage forms of Forsythia Suspense have similar anti-inflammatory, antitumor and antibacterial effects, but their effects for inhibiting IL-6, P65, and Jnk mRNA expressions and HCT116 cell proliferation differ significantly at low doses in zebrafish.PMID:38597452 | PMC:PMC11006694 | DOI:10.12122/j.issn.1673-4254.2024.03.22 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: X Guo Z Guo D Sun L Zou J Ou L Yu Z Lu H Cao J Liu Source Type: research

Screening of differentially expressed genes in gastric cancer based on GEO database and function and pathway enrichment analysis
CONCLUSION: SPARC, TIMP1, THBS2 and other DEGs are probably involved in GC occurrence and progression and may serve as potential candidate molecular markers for early diagnosis and prognostic evaluation of GC.PMID:38597453 | PMC:PMC11006697 | DOI:10.12122/j.issn.1673-4254.2024.03.23 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Y Liang Y Lai Y Yuan W Yuan X Zhang B Zhang Z Lu Source Type: research

Restraint stress induces blood-brain barrier injury in rat amygdala by activating the Rho/ROCK signaling pathway
CONCLUSION: Restraint stress induces BBB injury in the amygdala of rats by activating the Rho/ROCK signaling pathway.PMID:38597431 | PMC:PMC11006700 | DOI:10.12122/j.issn.1673-4254.2024.03.01 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: G Xu A Gao B Cong Source Type: research

Inhibition of glutamatergic neurons in the dorsomedial periaqueductal gray alleviates excessive defensive behaviors of mice with post-traumatic stress disorder
CONCLUSION: Inhibiting the activity of glutamatergic neurons in the dmPAG can alleviate defensive behaviors in mice with PTSD.PMID:38597432 | PMC:PMC11006690 | DOI:10.12122/j.issn.1673-4254.2024.03.02 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Y Li Y Guo F Cao S Guo D Xue Z Zhou X Hao L Tong Q Fu Source Type: research