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Rho kinase inhibitor Y27632 promotes survival of human induced pluripotent stem cells during differentiation into functional midbrain dopaminergic progenitor cells in < em > vitro < /em >
CONCLUSION: Treatment with Y27632 (5 μmol/L) for 24 h significantly promotes the survival of human iPSCs-NECs during their differentiation into DPAs without affecting the cell differentiation, which indirectly enhances the efficiency of cell differentiation.PMID:38501408 | PMC:PMC10954535 | DOI:10.12122/j.issn.1673-4254.2024.02.05 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: Y Li J Xu C Jiang Z Chen Y Chen M Ying A Wang C Ma C Wang Y Guo C Liu Source Type: research

Total saponins of < em > Panax japonicus < /em > alleviates CCl < sub > 4 < /sub > -induced acute liver injury in rats by regulating the PI3K/AktNF- κB signaling pathway
CONCLUSION: TSPJ can effectively alleviate CCl4-induced ALI in rats by suppressing inflammatory responses and oxidative stress in the liver via regulating the PI3K/Akt and SIRT6/NF-κB pathways.PMID:38501409 | PMC:PMC10954515 | DOI:10.12122/j.issn.1673-4254.2024.02.06 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: G Wu T Song L Tang Y Wang X Liu S Huang Source Type: research

Protective effect of FAK inhibitor PF-562271 against human umbilical vein endothelial cell injury induced by aging platelets
CONCLUSION: The FAK inhibitor PF-562271 alleviates endothelial cell damage induced by LPS and aging platelets by lowering cellular oxidative stress levels and reducing inflammatory responses.PMID:38501410 | PMC:PMC10954518 | DOI:10.12122/j.issn.1673-4254.2024.02.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: Y Bai B Gang M Zhang Z Wan G Liu W Gu Source Type: research

Prediction of microvascular invasion in hepatocellular carcinoma based on multi-phase dynamic enhanced CT radiomics feature and multi-classifier hierarchical fusion model
CONCLUSION: The proposed prediction model is effective for predicting MVI in HCC with superior performance to other models.PMID:38501411 | PMC:PMC10954521 | DOI:10.12122/j.issn.1673-4254.2024.02.08 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: W Zhong F Liang R Yang X Zhen Source Type: research

Resveratrol protects dopaminergic neurons in a mouse model of Parkinson's disease by regulating the gut-brain axis < em > via < /em > inhibiting the TLR4 signaling pathway
CONCLUSION: Resveratrol repairs the intestinal barrier by inhibiting TLR4/MyD88/NF-κB signaling pathway-mediated inflammatory response, thereby improving motor function and neuropathy in mouse models of MPTP-induced PD.PMID:38501412 | PMC:PMC10954533 | DOI:10.12122/j.issn.1673-4254.2024.02.09 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: J Gui X Sun S Wen X Liu B Qin M Sang Source Type: research