Journal of Southern Medical University This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A polylactic acid/hydroxyapatite/scholzite composite scaffold for promoting healing of osteoporotic bone defects in rats
CONCLUSION: PHZ scaffold is capable of stable Zn2+ release to promote osteoporotic bone defect healing, and PHZ-2 and PHZ-3 scaffolds with nZCP mass fraction of 4.5%-7.5% have better osteogenic activity.PMID:38501423 | PMC:PMC10954527 | DOI:10.12122/j.issn.1673-4254.2024.02.20 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: C Luo J Chen Q Zhang X Yu S Zhang Source Type: research

Tea polyphenols ameliorates acute lung injury in septic mice by inhibiting NLRP3 inflammasomes
CONCLUSION: TP inhibits NLRP3 inflammasome-associated inflammation to alleviate CLP-induced acute lung injury in mice through a regulatory mechanism that inhibits NOX4 expression and reduces oxidative stress in the lung tissue.PMID:38501424 | PMC:PMC10954520 | DOI:10.12122/j.issn.1673-4254.2024.02.21 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: X Ling W Xu G Pang X Hong F Liu Y Li Source Type: research

A multiscale carotid plaque detection method based on two-stage analysis
CONCLUSION: The proposed carotid artery plaque detection method has good performance for accurate identification of carotid plaques in ultrasound images.PMID:38501425 | PMC:PMC10954526 | DOI:10.12122/j.issn.1673-4254.2024.02.22 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: H Xiao W Fang M Lin Z Zhou H Fei C Chen Source Type: research

A clinical-radiomics nomogram for differentiating focal organizing pneumonia and lung adenocarcinoma
CONCLUSION: The clinical-radiomics nomogram model shows a good performance for differential diagnosis of FOP and LUAD and may help to minimize misdiagnosis-related overtreatment and improve the patients' outcomes.PMID:38501426 | PMC:PMC10954529 | DOI:10.12122/j.issn.1673-4254.2024.02.23 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: Y Liu C Li J Guo Y Liu Source Type: research

Modulating gut microbiota improves neurological function and depressive symptoms in rats with post-stroke depression
CONCLUSION: In PSD rats, TMAO/H2S ratio is correlated with neurological function score, immobility time in forced swimming and sugar water preference, and modulating intestinal flora can improve neurological function and depressive symptoms and improve the integrity of the blood-brain barrier.PMID:38501427 | PMC:PMC10954514 | DOI:10.12122/j.issn.1673-4254.2024.02.24 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: X Li Y Liu K Deng Y Hu Source Type: research

Adeno-associated virus-mediated hepatocyte-specific NDUFA13 overexpression protects against CCl 4 -induced liver fibrosis in mice by inhibiting hepatic NLRP3 activation
CONCLUSION: Mitochondrial NDUFA13 overexpression in hepatocytes protects against CCl4- induced liver fibrosis in mice by inhibiting activation of NLRP3 signaling.PMID:38501404 | PMC:PMC10954519 | DOI:10.12122/j.issn.1673-4254.2024.02.01 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: X Xu J Feng Y Luo X He J Zang D Huang Source Type: research

Efficacy of combined treatment with pirfenidone and PD-L1 inhibitor in mice bearing ectopic bladder cancer xenograft
CONCLUSION: Combined treatment with pirfenidone and PD-L1 inhibitor significantly inhibits the progression of bladder cancer in mice possibly by regulating tumor immune microenvironment and inhibiting epithelial-mesenchymal transition of the tumor cells.PMID:38501405 | PMC:PMC10954534 | DOI:10.12122/j.issn.1673-4254.2024.02.02 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: S Chen S Zhang W Fan W Sun B Liu J Liu Y Guo Source Type: research

Efficacy of navel application of Jianpiwenyang Gel for chronic diarrhea of spleen and stomach weakness type: a randomized controlled trial and analysis of the mechanism
CONCLUSION: SSWYG can significantly improve clinical symptoms of chronic diarrhea possibly by regulating the TNF and IL-17 as well as other pathways via CASP3 and JUN, suggesting a complex therapeutic mechanism of SSWYG involving multiple ingredients and targets and coordinated regulation of multiple pathways.PMID:38501406 | PMC:PMC10954536 | DOI:10.12122/j.issn.1673-4254.2024.02.03 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: Y Cui D Wang D Xie H Wang R Xu X Tang Y Zhang Source Type: research

Colchicine alleviates myocardial ischemia-reperfusion injury in mice by activating AMPK
CONCLUSION: Colchicine alleviates myocardial I/R injury and protects cardiac function in mice by reducing myocardial oxidative stress and apoptosis via activating AMPK.PMID:38501407 | PMC:PMC10954522 | DOI:10.12122/j.issn.1673-4254.2024.02.04 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: G Chen S Luo Source Type: research

Rho kinase inhibitor Y27632 promotes survival of human induced pluripotent stem cells during differentiation into functional midbrain dopaminergic progenitor cells in vitro 
CONCLUSION: Treatment with Y27632 (5 μmol/L) for 24 h significantly promotes the survival of human iPSCs-NECs during their differentiation into DPAs without affecting the cell differentiation, which indirectly enhances the efficiency of cell differentiation.PMID:38501408 | PMC:PMC10954535 | DOI:10.12122/j.issn.1673-4254.2024.02.05 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: Y Li J Xu C Jiang Z Chen Y Chen M Ying A Wang C Ma C Wang Y Guo C Liu Source Type: research

Total saponins of Panax japonicus alleviates CCl 4 -induced acute liver injury in rats by regulating the PI3K/AktNF- κB signaling pathway
CONCLUSION: TSPJ can effectively alleviate CCl4-induced ALI in rats by suppressing inflammatory responses and oxidative stress in the liver via regulating the PI3K/Akt and SIRT6/NF-κB pathways.PMID:38501409 | PMC:PMC10954515 | DOI:10.12122/j.issn.1673-4254.2024.02.06 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: G Wu T Song L Tang Y Wang X Liu S Huang Source Type: research

Protective effect of FAK inhibitor PF-562271 against human umbilical vein endothelial cell injury induced by aging platelets
CONCLUSION: The FAK inhibitor PF-562271 alleviates endothelial cell damage induced by LPS and aging platelets by lowering cellular oxidative stress levels and reducing inflammatory responses.PMID:38501410 | PMC:PMC10954518 | DOI:10.12122/j.issn.1673-4254.2024.02.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: Y Bai B Gang M Zhang Z Wan G Liu W Gu Source Type: research

Prediction of microvascular invasion in hepatocellular carcinoma based on multi-phase dynamic enhanced CT radiomics feature and multi-classifier hierarchical fusion model
CONCLUSION: The proposed prediction model is effective for predicting MVI in HCC with superior performance to other models.PMID:38501411 | PMC:PMC10954521 | DOI:10.12122/j.issn.1673-4254.2024.02.08 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: W Zhong F Liang R Yang X Zhen Source Type: research

Resveratrol protects dopaminergic neurons in a mouse model of Parkinson's disease by regulating the gut-brain axis via inhibiting the TLR4 signaling pathway
CONCLUSION: Resveratrol repairs the intestinal barrier by inhibiting TLR4/MyD88/NF-κB signaling pathway-mediated inflammatory response, thereby improving motor function and neuropathy in mouse models of MPTP-induced PD.PMID:38501412 | PMC:PMC10954533 | DOI:10.12122/j.issn.1673-4254.2024.02.09 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: J Gui X Sun S Wen X Liu B Qin M Sang Source Type: research

Demethylzeylasteral inhibits proliferation, migration and invasion and promotes apoptosis of non-small cell lung cancer cells by inhibiting the AKT/CREB signaling pathway
CONCLUSION: T-96 inhibits the proliferation, migration and invasion and induces apoptosis of NSCLC cells possibly by inhibiting the AKT/CREB signaling pathway.PMID:38501413 | PMC:PMC10954516 | DOI:10.12122/j.issn.1673-4254.2024.02.10 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: Q Han M Ye Q Jin Source Type: research