Journal of Southern Medical University This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Adeno-associated virus-mediated hepatocyte-specific NDUFA13 overexpression protects against CCl 4 -induced liver fibrosis in mice by inhibiting hepatic NLRP3 activation
CONCLUSION: Mitochondrial NDUFA13 overexpression in hepatocytes protects against CCl4- induced liver fibrosis in mice by inhibiting activation of NLRP3 signaling.PMID:38501404 | PMC:PMC10954519 | DOI:10.12122/j.issn.1673-4254.2024.02.01 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: X Xu J Feng Y Luo X He J Zang D Huang Source Type: research

Efficacy of combined treatment with pirfenidone and PD-L1 inhibitor in mice bearing ectopic bladder cancer xenograft
CONCLUSION: Combined treatment with pirfenidone and PD-L1 inhibitor significantly inhibits the progression of bladder cancer in mice possibly by regulating tumor immune microenvironment and inhibiting epithelial-mesenchymal transition of the tumor cells.PMID:38501405 | PMC:PMC10954534 | DOI:10.12122/j.issn.1673-4254.2024.02.02 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: S Chen S Zhang W Fan W Sun B Liu J Liu Y Guo Source Type: research

Efficacy of navel application of Jianpiwenyang Gel for chronic diarrhea of spleen and stomach weakness type: a randomized controlled trial and analysis of the mechanism
CONCLUSION: SSWYG can significantly improve clinical symptoms of chronic diarrhea possibly by regulating the TNF and IL-17 as well as other pathways via CASP3 and JUN, suggesting a complex therapeutic mechanism of SSWYG involving multiple ingredients and targets and coordinated regulation of multiple pathways.PMID:38501406 | PMC:PMC10954536 | DOI:10.12122/j.issn.1673-4254.2024.02.03 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: Y Cui D Wang D Xie H Wang R Xu X Tang Y Zhang Source Type: research

Colchicine alleviates myocardial ischemia-reperfusion injury in mice by activating AMPK
CONCLUSION: Colchicine alleviates myocardial I/R injury and protects cardiac function in mice by reducing myocardial oxidative stress and apoptosis via activating AMPK.PMID:38501407 | PMC:PMC10954522 | DOI:10.12122/j.issn.1673-4254.2024.02.04 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: G Chen S Luo Source Type: research

Rho kinase inhibitor Y27632 promotes survival of human induced pluripotent stem cells during differentiation into functional midbrain dopaminergic progenitor cells in vitro 
CONCLUSION: Treatment with Y27632 (5 μmol/L) for 24 h significantly promotes the survival of human iPSCs-NECs during their differentiation into DPAs without affecting the cell differentiation, which indirectly enhances the efficiency of cell differentiation.PMID:38501408 | PMC:PMC10954535 | DOI:10.12122/j.issn.1673-4254.2024.02.05 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: Y Li J Xu C Jiang Z Chen Y Chen M Ying A Wang C Ma C Wang Y Guo C Liu Source Type: research

Total saponins of Panax japonicus alleviates CCl 4 -induced acute liver injury in rats by regulating the PI3K/AktNF- κB signaling pathway
CONCLUSION: TSPJ can effectively alleviate CCl4-induced ALI in rats by suppressing inflammatory responses and oxidative stress in the liver via regulating the PI3K/Akt and SIRT6/NF-κB pathways.PMID:38501409 | PMC:PMC10954515 | DOI:10.12122/j.issn.1673-4254.2024.02.06 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: G Wu T Song L Tang Y Wang X Liu S Huang Source Type: research

Protective effect of FAK inhibitor PF-562271 against human umbilical vein endothelial cell injury induced by aging platelets
CONCLUSION: The FAK inhibitor PF-562271 alleviates endothelial cell damage induced by LPS and aging platelets by lowering cellular oxidative stress levels and reducing inflammatory responses.PMID:38501410 | PMC:PMC10954518 | DOI:10.12122/j.issn.1673-4254.2024.02.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: Y Bai B Gang M Zhang Z Wan G Liu W Gu Source Type: research

Prediction of microvascular invasion in hepatocellular carcinoma based on multi-phase dynamic enhanced CT radiomics feature and multi-classifier hierarchical fusion model
CONCLUSION: The proposed prediction model is effective for predicting MVI in HCC with superior performance to other models.PMID:38501411 | PMC:PMC10954521 | DOI:10.12122/j.issn.1673-4254.2024.02.08 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: W Zhong F Liang R Yang X Zhen Source Type: research

Resveratrol protects dopaminergic neurons in a mouse model of Parkinson's disease by regulating the gut-brain axis via inhibiting the TLR4 signaling pathway
CONCLUSION: Resveratrol repairs the intestinal barrier by inhibiting TLR4/MyD88/NF-κB signaling pathway-mediated inflammatory response, thereby improving motor function and neuropathy in mouse models of MPTP-induced PD.PMID:38501412 | PMC:PMC10954533 | DOI:10.12122/j.issn.1673-4254.2024.02.09 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: J Gui X Sun S Wen X Liu B Qin M Sang Source Type: research

Demethylzeylasteral inhibits proliferation, migration and invasion and promotes apoptosis of non-small cell lung cancer cells by inhibiting the AKT/CREB signaling pathway
CONCLUSION: T-96 inhibits the proliferation, migration and invasion and induces apoptosis of NSCLC cells possibly by inhibiting the AKT/CREB signaling pathway.PMID:38501413 | PMC:PMC10954516 | DOI:10.12122/j.issn.1673-4254.2024.02.10 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: Q Han M Ye Q Jin Source Type: research

High expression of COX6B2 in gastric cancer is associated with poor long-term prognosis and promotes cell proliferation and cell cycle progression by inhibiting p53 signaling
CONCLUSION: s COX6B2 is highly expressed in gastric cancer and is closely correlated with a poor long-term prognosis of the patients possibly by promoting gastric cancer cell proliferation and regulating cell cycle.PMID:38501414 | PMC:PMC10954525 | DOI:10.12122/j.issn.1673-4254.2024.02.11 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: M Shen N Zhao X Deng M Deng Source Type: research

Adiponectin improves endometrial receptivity in rats with polycystic ovary syndrome by upregulating the PPAR α/HOXA10 pathway
CONCLUSION: APN can improve endometrial receptivity in PCOS rats by upregulating the PARα/HOXA10 pathway.PMID:38501415 | PMC:PMC10954532 | DOI:10.12122/j.issn.1673-4254.2024.02.12 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: J Wang W Yang J Liu J Shi P Xiao M Li Source Type: research

Correlation of serum ferredoxin 1 and lipoic acid levels with severity of coronary artery disease
CONCLUSION: Serum FDX1 and LA levels decrease with worsening of coronary artery lesions, and theirs expressions are correlated with coronary artery lesions induced by hyperlipidemia.PMID:38501416 | PMC:PMC10954524 | DOI:10.12122/j.issn.1673-4254.2024.02.13 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: T Wei Y Ding J Zhang J Li H Zhang P Kang N Zhang Source Type: research

Chlorogenic acid alleviates acute kidney injury in septic mice by inhibiting NLRP3 inflammasomes and the caspase-1 canonical pyroptosis pathway
CONCLUSION: CGA alleviates AKI in mice with CLP-induced sepsis by inhibiting NLRP3 inflammasomes and the caspase-1 signaling pathway.PMID:38501417 | PMC:PMC10954528 | DOI:10.12122/j.issn.1673-4254.2024.02.14 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: S Fang R Sun H Su K Zhai Y Xiang Y Gao W Guo Source Type: research

PCID2 is highly expressed in gastric cancer and affects the prognosis by regulating cancer cell cycle and proliferation
CONCLUSION: PCID2 is highly expressed in gastric cancer tissues in close correlation with poor prognosis of the patients. High PCID2 expression promotes gastric cancer proliferation and cell cycle progression by inhibiting the expression of p27 and p16.PMID:38501418 | PMC:PMC10954517 | DOI:10.12122/j.issn.1673-4254.2024.02.15 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: N Zhang Z Zhang Y Zhang X Song X Zhang J Li L Zuo J Hu Source Type: research