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High LINC00626 expression promotes esophagogastric junction adenocarcinoma metastasis: the mediating role of the JAK1/STAT3/KHSRP axis
CONCLUSION: High LINC00626 expression promotes esophageal-gastric junction adenocarcinoma metastasis by activating the JAK1/STAT3/KHSRP signal axis.PMID:38597446 | PMC:PMC11006707 | DOI:10.12122/j.issn.1673-4254.2024.03.16 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: F Zhang L Fan X Kang H Wei L Li Source Type: research

Predictive value of cardiac magnetic resonance imaging for adverse left ventricular remodeling after acute ST-segment elevation myocardial infarction
CONCLUSION: The extent of infarct mass, peak radial diastolic strain rate, and RAAS inhibitor are independent predictors of adverse LV remodeling following STEMI.PMID:38597447 | PMC:PMC11006702 | DOI:10.12122/j.issn.1673-4254.2024.03.17 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Cui W Liu F Yan Y Zhao W Chen C Luo X Zhang T Li Source Type: research

PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMK Ⅱγ and CaMKⅡδ against ischemic reperfusion injury in mice
CONCLUSION: The neuroprotective effects of CaMKⅡδ and CaMKⅡγ against acute neuronal ischemic reperfusion injury are mediated probably by the PI3K/Akt/Erk pathway.PMID:38597448 | PMC:PMC11006692 | DOI:10.12122/j.issn.1673-4254.2024.03.18 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: H Liu Z Lin J Ye Source Type: research

MiR-132-3p negatively regulates CAMTA1 to promote Schwann cell proliferation and migration and alleviates I-125 seeds-induced exacerbation of facial nerve injury in rats
CONCLUSION: Overexpression of miR-132-3p suppresses CAMTA1 expression and promotes Schwann cell proliferation and migration to alleviate I-125 seeds-induced exacerbation of FNI in rats.PMID:38597449 | PMC:PMC11006691 | DOI:10.12122/j.issn.1673-4254.2024.03.19 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Zhu X Ouyang Y Liu Y Qian B Xia Y Shi L Yu Source Type: research

MiR-26-3p regulates proliferation, migration, invasion and apoptosis of glioma cells by targeting CREB1
CONCLUSION: MiR-26b-3p regulates CREB1 expression to modulate apoptosis, proliferation, migration and invasion of glioma cells, thereby participating in tumorigenesis and progression of glioma.PMID:38597450 | PMC:PMC11006701 | DOI:10.12122/j.issn.1673-4254.2024.03.20 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Q Huang J Zhou Z Wang K Yang Z Chen Source Type: research

Automatic classification of immune-mediated glomerular diseases based on multi-modal multi-instance learning
CONCLUSION: This multi- modal multi- instance model based on OM, IM, and TEM images can achieve automatic classification of immune-mediated glomerular diseases with a good classification accuracy.PMID:38597451 | PMC:PMC11006708 | DOI:10.12122/j.issn.1673-4254.2024.03.21 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: K Long D Weng J Geng Y Lu Z Zhou L Cao Source Type: research

Single extract of Forsythia Suspense versus the prepared drug in pieces: comparison of their anti-inflammatory, antitumor and antibacterial effects in zebrafish
CONCLUSION: The two dosage forms of Forsythia Suspense have similar anti-inflammatory, antitumor and antibacterial effects, but their effects for inhibiting IL-6, P65, and Jnk mRNA expressions and HCT116 cell proliferation differ significantly at low doses in zebrafish.PMID:38597452 | PMC:PMC11006694 | DOI:10.12122/j.issn.1673-4254.2024.03.22 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: X Guo Z Guo D Sun L Zou J Ou L Yu Z Lu H Cao J Liu Source Type: research

Screening of differentially expressed genes in gastric cancer based on GEO database and function and pathway enrichment analysis
CONCLUSION: SPARC, TIMP1, THBS2 and other DEGs are probably involved in GC occurrence and progression and may serve as potential candidate molecular markers for early diagnosis and prognostic evaluation of GC.PMID:38597453 | PMC:PMC11006697 | DOI:10.12122/j.issn.1673-4254.2024.03.23 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Y Liang Y Lai Y Yuan W Yuan X Zhang B Zhang Z Lu Source Type: research

Restraint stress induces blood-brain barrier injury in rat amygdala by activating the Rho/ROCK signaling pathway
CONCLUSION: Restraint stress induces BBB injury in the amygdala of rats by activating the Rho/ROCK signaling pathway.PMID:38597431 | PMC:PMC11006700 | DOI:10.12122/j.issn.1673-4254.2024.03.01 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: G Xu A Gao B Cong Source Type: research

Inhibition of glutamatergic neurons in the dorsomedial periaqueductal gray alleviates excessive defensive behaviors of mice with post-traumatic stress disorder
CONCLUSION: Inhibiting the activity of glutamatergic neurons in the dmPAG can alleviate defensive behaviors in mice with PTSD.PMID:38597432 | PMC:PMC11006690 | DOI:10.12122/j.issn.1673-4254.2024.03.02 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Y Li Y Guo F Cao S Guo D Xue Z Zhou X Hao L Tong Q Fu Source Type: research

Metformin suppresses hypoxia-inducible factor-1 < em > α < /em > expression in cancer-associated fibroblasts to block tumor-stromal cross-talk in breast cancer
CONCLUSION: Metformin suppresses HIF-1α expression in CAFs to block tumor-stromal cross talk in breast cancer.PMID:38597433 | PMC:PMC11006696 | DOI:10.12122/j.issn.1673-4254.2024.03.03 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: S Shao W Bai P Zhou M Luo X Zhao J Lei Source Type: research

Metformin ameliorates PM2.5-induced functional impairment of placental trophoblasts by inhibiting ferroptosis
CONCLUSION: PM2.5 exposure during pregnancy causes adverse pregnancy outcomes and ferroptosis and functional impairment of placental trophoblasts in mice, and metformin can effectively alleviate PM2.5-induced trophoblast impairment.PMID:38597434 | PMC:PMC11006689 | DOI:10.12122/j.issn.1673-4254.2024.03.04 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: S Li S Yu Y Mu K Wang Y Liu M Zhang Source Type: research

< em > Huangpu Tongqiao < /em > Capsule improves cognitive impairment in rats with Wilson disease by inhibiting endoplasmic reticulum stress-mediated apoptosis pathway
CONCLUSION: HPTQ Capsule has neuroprotective effects in rat models of WD possibly by inhibiting ERS-mediated apoptosis pathway.PMID:38597435 | PMC:PMC11006687 | DOI:10.12122/j.issn.1673-4254.2024.03.05 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: X Zhang X Wang J Wang N Shao B Cai D Xie Source Type: research

High expression of UBE2S promotes progression of hepatocellular carcinoma by increasing cancer cell stemness
CONCLUSION: UBE2S is highly expressed in T cells in HCC microenvironment in close correlation with a poor prognosis. High UBE2S expression promotes the stemness of HCC cells.PMID:38597436 | PMC:PMC11006698 | DOI:10.12122/j.issn.1673-4254.2024.03.06 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: H Chen Z Li M Wang L Lu Q Tang L Luo Source Type: research

< em > Jianpi Zishen < /em > granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study
CONCLUSION: The therapeutic effect of JPZS granules on SLE is mediated probably by coordinated actions of quercetin, kaempferol, β-sitosterol, and isorhamnetin on their target gene STAT1 to inhibit the JAK/STAT pathway, thus suppressing autophagy and alleviating podocyte injuries in SLE.PMID:38597437 | PMC:PMC11006693 | DOI:10.12122/j.issn.1673-4254.2024.03.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Chen C Huang M Li Source Type: research