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High expression of UBE2S promotes progression of hepatocellular carcinoma by increasing cancer cell stemness
CONCLUSION: UBE2S is highly expressed in T cells in HCC microenvironment in close correlation with a poor prognosis. High UBE2S expression promotes the stemness of HCC cells.PMID:38597436 | DOI:10.12122/j.issn.1673-4254.2024.03.06 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: H Chen Z Li M Wang L Lu Q Tang L Luo Source Type: research

 Jianpi Zishen granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study
CONCLUSION: The therapeutic effect of JPZS granules on SLE is mediated probably by coordinated actions of quercetin, kaempferol, β-sitosterol, and isorhamnetin on their target gene STAT1 to inhibit the JAK/STAT pathway, thus suppressing autophagy and alleviating podocyte injuries in SLE.PMID:38597437 | DOI:10.12122/j.issn.1673-4254.2024.03.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Chen C Huang M Li Source Type: research

3-O- β-chacotriosyl glycyrrhetinic acid derivatives as potential small-molecule SARS-CoV-2 fusion inhibitors against SARS-CoV-2 entry into host cells
CONCLUSION: 3-O-β-chacotriosyl glycyrrhetinic acid derivatives are capable of stabilizing spike protein in the pre-fusion step to interfere with the fusion of SARS-CoV-2 with host cell membrane, and can thus serve as potential novel small-molecule SARS-CoV-2 fusion inhibitors.PMID:38597438 | DOI:10.12122/j.issn.1673-4254.2024.03.08 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: X Wan C Hong J Wang G Song S Liu Source Type: research

Lung-protective effect of esketamine combined with distal limb ischemic preconditioning in elderly patients undergoing thoracoscopic radical surgery for lung cancer: a randomized controlled trial in 160 cases
CONCLUSION: In elderly patients undergoing thoracoscopic radical surgery for lung cancer, treatment with esketamine combined with LIP can alleviate acute lung injury by enhancing anti-inflammatory response to shorten postoperative hospital stay, reduce lung complications and promote the patients' recovery.PMID:38597439 | DOI:10.12122/j.issn.1673-4254.2024.03.09 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Y Yang G Liu Y Ou W Lu Source Type: research

Construction and validation of an in-hospital mortality risk prediction model for patients receiving VA-ECMO: a retrospective multi-center case-control study
CONCLUSION: The risk prediction model for in-hospital mortality of patients on VA-ECMO has good differentiation, calibration and clinical effectiveness and outperforms the commonly used disease severity scoring system, and thus can be used for assessing disease severity and prognostic risk level in critically ill patients.PMID:38597440 | DOI:10.12122/j.issn.1673-4254.2024.03.10 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Y Ge J Li H Liang L Hou L Zuo Z Chen J Lu X Zhao J Liang L Peng J Bao J Duan L Liu K Mao Z Zeng H Hu Z Chen Source Type: research

Activation of α 7 nAChR improves white fat homeostasis and promotes beige adipogenesis and thermogenesis in obese mice
CONCLUSION: Activation of α7 nAchR improves white adipose tissue homeostasis impairment induced by β3 agonist, promotes transformation of M1 to M2 macrophages, reduces inflammatory response in white adipose tissue, and promote beige adipogenesis and thermogenesis in obese mice.PMID:38597441 | DOI:10.12122/j.issn.1673-4254.2024.03.11 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: H Bao S Wang M L ü Y Wang P Jiang X Li Source Type: research

HTD4010 attenuates myocardial injury in mice with septic cardiomyopathy by promoting autophagy via the AMPK/mTOR signaling pathway
CONCLUSION: HTD4010 can attenuate myocardial injury in SCM mice possibly by promoting autophagy via modulating the AMPK/mTOR signaling pathway.PMID:38597442 | DOI:10.12122/j.issn.1673-4254.2024.03.12 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: H Xiao B Han J Guo C Wu J Wu Source Type: research

Saikosaponin a alleviates pentylenetetrazol-induced acute epileptic seizures in mouse models of depression by suppressing microglia activation-mediated inflammation
CONCLUSION: Depressive state aggravates epileptic seizures, increases microglia activation, and elevates inflammation levels. SSA treatment can alleviate acute epileptic seizures in mouse models of depression possibly by suppressing microglia activation-mediated inflammation.PMID:38597443 | DOI:10.12122/j.issn.1673-4254.2024.03.13 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Y Xiong X Liang X Liang W Li Y Qian W Xie Source Type: research

Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats
CONCLUSION: Asiaticoside induces thoracic aorta relaxation by mediating high-conductance calcium-activated potassium channel opening, promoting nitric oxide release from endothelial cells and regulating Ca2+ influx and outflow, thereby reducing systolic blood pressure in rats.PMID:38597444 | DOI:10.12122/j.issn.1673-4254.2024.03.14 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: G Lu H Sun Z Sun L Liu L Wang N Zhang Y Wang Y He J Ji X Li P Kang B Tang Source Type: research

A sericin hydrogel scaffold for sustained dexamethasone release modulates macrophage polarization to promote mandibular bone defect repair in rats
CONCLUSION: The SMH-CD/DEX scaffold capable of sustained dexamethasone release promotes osteogenic differentiation of stem cells and bone defect repair in rats by regulating M2 polarization.PMID:38597445 | DOI:10.12122/j.issn.1673-4254.2024.03.15 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Y Fan M Luo D Huang L Liu B Fu X Wang M Guan H Li Source Type: research

High LINC00626 expression promotes esophagogastric junction adenocarcinoma metastasis: the mediating role of the JAK1/STAT3/KHSRP axis
CONCLUSION: High LINC00626 expression promotes esophageal-gastric junction adenocarcinoma metastasis by activating the JAK1/STAT3/KHSRP signal axis.PMID:38597446 | DOI:10.12122/j.issn.1673-4254.2024.03.16 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: F Zhang L Fan X Kang H Wei L Li Source Type: research

Predictive value of cardiac magnetic resonance imaging for adverse left ventricular remodeling after acute ST-segment elevation myocardial infarction
CONCLUSION: The extent of infarct mass, peak radial diastolic strain rate, and RAAS inhibitor are independent predictors of adverse LV remodeling following STEMI.PMID:38597447 | DOI:10.12122/j.issn.1673-4254.2024.03.17 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Cui W Liu F Yan Y Zhao W Chen C Luo X Zhang T Li Source Type: research

PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMK Ⅱγ and CaMKⅡδ against ischemic reperfusion injury in mice
CONCLUSION: The neuroprotective effects of CaMKⅡδ and CaMKⅡγ against acute neuronal ischemic reperfusion injury are mediated probably by the PI3K/Akt/Erk pathway.PMID:38597448 | DOI:10.12122/j.issn.1673-4254.2024.03.18 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: H Liu Z Lin J Ye Source Type: research

MiR-132-3p negatively regulates CAMTA1 to promote Schwann cell proliferation and migration and alleviates I-125 seeds-induced exacerbation of facial nerve injury in rats
CONCLUSION: Overexpression of miR-132-3p suppresses CAMTA1 expression and promotes Schwann cell proliferation and migration to alleviate I-125 seeds-induced exacerbation of FNI in rats.PMID:38597449 | DOI:10.12122/j.issn.1673-4254.2024.03.19 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Zhu X Ouyang Y Liu Y Qian B Xia Y Shi L Yu Source Type: research

MiR-26-3p regulates proliferation, migration, invasion and apoptosis of glioma cells by targeting CREB1
CONCLUSION: MiR-26b-3p regulates CREB1 expression to modulate apoptosis, proliferation, migration and invasion of glioma cells, thereby participating in tumorigenesis and progression of glioma.PMID:38597450 | DOI:10.12122/j.issn.1673-4254.2024.03.20 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Q Huang J Zhou Z Wang K Yang Z Chen Source Type: research