Effectiveness of mobile health  interventions for pregnant women with gestational diabetes mellitus: a systematic review and meta-analysis
This study aimed to systematically evaluate the effectiveness of mHealth intervention in pregnant women with GDM. Based on randomised controlled trials of mHealth application in GDM patients searched from the database, literature screening, data extraction, and quality evaluation were conducted independently by two researchers. Statistical analysis was performed using Review Manager 5.4 software. The review included 27 studies with a total of 3483 patients. The results showed a significant improvement in glycemic control. In addition, mHealth interventions could reduce the occurrence of adverse pregnancy outcomes and impro...
Source: Journal of Obstetrics and Gynaecology - August 22, 2023 Category: OBGYN Authors: Hui Xin Wei Yi Ling Yang Ting Yu Luo Wei Qiang Chen Source Type: research

CircEpha5 regulates the synthesis and secretion of androgen in mouse preantral follicles by targeting miR-758-5p
This article assessed the circRNAs expression profile in the ovaries of PCOS mice by circRNAs high-throughput sequencing and explored the role of circEpha5 in hyperandrogenism. The results showed that the overexpression of circEpha5 in mouse preantral follicles could increase the expression of Cyp17a1, an androgen synthesis-related gene, which resulted in a higher serum level of testosterone. Dual-luciferase reporter gene studies identified miR-758-5p as a direct target of circEpha5. Consequently, miR-758-5p expression was downregulated upon circEpha5 overexpression. Ectopically expressed miR-758-5p reversed the stimulatio...
Source: Journal of Obstetrics and Gynaecology - August 9, 2023 Category: OBGYN Authors: Xueying Zhang Jiaxuan Liu Hao Wu Yan Chen Xuesen Zhang Boqun Xu Source Type: research