CXCL10 upregulation in radiation-exposed human peripheral blood mononuclear cells as a candidate biomarker for rapid triage after radiation exposure
CONCLUSIONS: CXCL10 expression in irradiated PBMCs represents a potential biomarker for radiation exposure.PMID:38227479 | DOI:10.1080/09553002.2023.2295300 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 16, 2024 Category: Radiology Authors: Seo Young Kwak Ji-Hye Park Hee-Young Won Hyosun Jang Seung Bum Lee Won Il Jang Sunhoo Park Min-Jung Kim Sehwan Shim Source Type: research

Validation of genes for H-ARS severity prediction in leukemia patients - interspecies comparison, challenges, and promises
CONCLUSION: Identified genes for H-ARS severity prediction, previously detected in baboons, were validated in ALL but not in AML patients. Limitations related to leukemia type, associated reduced RNA amounts, suppressed GE changes, and methodological challenges must be considered as factors negatively affecting the total number of validated genes. Based on that, we propose additional controls including blood cell counts and preferably fluorescence-based RNA quantity measurements for selecting promising samples and using a more sensitive 96-well format for candidate genes with low baseline copy numbers.PMID:38227483 | DOI:1...
Source: International Journal of Radiation Biology - January 16, 2024 Category: Radiology Authors: Daniel Schwanke Marco Valente Patrick Ostheim Simone Sch üle Laure Bobyk Michel Drouet Diane Riccobono Nicolas Magn é Elisabeth Daguenet Samantha Jo Stewart Razan Muhtadi Matthias Port Michael Abend Source Type: research

Lifetime attributable risks (LARs) of cancer in the fetus associated with maternal radiography examinations
CONCLUSION: The radiation dose incurred by the fetus due to chest and skull radiographs was minimal and unlikely to cause any abnormalities in the fetus. The discernible elevation in the lifetime attributable risk associated with cancer incidence and mortality arising from lateral computed radiography examinations of the abdomen warrants careful consideration within the realm of maternal radiography examinations.PMID:38193807 | DOI:10.1080/09553002.2023.2295294 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 9, 2024 Category: Radiology Authors: Asra Sadat Talebi Roghiyeh Bodaghi Saeed Bagherzadeh Source Type: research

Consideration of hereditary effects in the radiological protection system: evolution and current status
CONCLUSION: Further research and advancements in this field are crucial for enhancing our understanding and addressing the complexities involved in assessing and managing the risks associated with hereditary effects of radiation.PMID:38190433 | DOI:10.1080/09553002.2023.2295289 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 8, 2024 Category: Radiology Authors: A Amrenova E Ainsbury C Baudin A Giussani J Lochard W R ühm P Scholz-Kreisel K Trott L Vaillant R Wakeford F Z ölzer D Laurier Source Type: research

High-density polyethylene (HDPE)-incorporated boron carbide and boric acid nanoparticles as a nanoshield of photoneutrons from medical linear accelerators
CONCLUSIONS: The research suggests that utilizing boron carbide and boric acid nanoshields in combination with HDPE holds promise as a viable approach to protecting from the photoneutrons. Further exploration of these nanocomposite shields and their practical applications is warranted, with the potential to yield significant advancements in radiation therapy safety and efficacy.PMID:38190436 | DOI:10.1080/09553002.2023.2295964 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 8, 2024 Category: Radiology Authors: Ali Vegari Akbar Abdisaray Kamal Mostafanejad Nasrollah Jabbari Source Type: research

Consideration of hereditary effects in the radiological protection system: evolution and current status
CONCLUSION: Further research and advancements in this field are crucial for enhancing our understanding and addressing the complexities involved in assessing and managing the risks associated with hereditary effects of radiation.PMID:38190433 | DOI:10.1080/09553002.2023.2295289 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 8, 2024 Category: Radiology Authors: A Amrenova E Ainsbury C Baudin A Giussani J Lochard W R ühm P Scholz-Kreisel K Trott L Vaillant R Wakeford F Z ölzer D Laurier Source Type: research

High-density polyethylene (HDPE)-incorporated boron carbide and boric acid nanoparticles as a nanoshield of photoneutrons from medical linear accelerators
CONCLUSIONS: The research suggests that utilizing boron carbide and boric acid nanoshields in combination with HDPE holds promise as a viable approach to protecting from the photoneutrons. Further exploration of these nanocomposite shields and their practical applications is warranted, with the potential to yield significant advancements in radiation therapy safety and efficacy.PMID:38190436 | DOI:10.1080/09553002.2023.2295964 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 8, 2024 Category: Radiology Authors: Ali Vegari Akbar Abdisaray Kamal Mostafanejad Nasrollah Jabbari Source Type: research

Radiotherapy for non-cancer diseases: benefits and long-term risks
CONCLUSIONS: A growing body of evidence has suggested that radiation represents a double-edged sword, not only for cancer, but also for non-cancer diseases. At present, clinical evidence has shown some beneficial effects of radiotherapy for ventricular tachycardia, but there is little or no such evidence of radiotherapy for other newly proposed non-cancer diseases (e.g. Alzheimer's disease, COVID-19 pneumonia). Patients with ventricular tachycardia and COVID-19 pneumonia have thus far been treated with radiotherapy when they are an urgent life threat with no efficient alternative treatment, but some survivors may encounter...
Source: International Journal of Radiation Biology - January 5, 2024 Category: Radiology Authors: Juliette Thariat Mark P Little Lydia B Zablotska Pamela Samson M Kerry O'Banion Klervi Leuraud Carmen Bergom Gilles Girault Omid Azimzadeh Simon Bouffler Nobuyuki Hamada Source Type: research

< em > In utero < /em > exposure to ionizing radiation and metabolic regulation: perspectives for future multi- and trans-generation effects studies
CONCLUSIONS: Knowledge consolidation in the field of Developmental Origins of Health and Disease (DOHaD) has led us to propose a new study strategy. This strategy aims to address the transgenerational effects of in utero exposure to low dose and low dose-rate radiation. Within this concept, there is a possibility that disruption of epigenetic programming in embryonic and fetal cells may occur. This disruption could lead to metabolic dysfunction, which in turn may cause abnormal responses to future environmental challenges, consequently increasing disease risk. Lastly, we discuss methodological limitations in our studies. T...
Source: International Journal of Radiation Biology - January 5, 2024 Category: Radiology Authors: St éphane Grison Ignacia Iii Braga-Tanaka Sarah Baatout Dmitry Klokov Source Type: research

Radiotherapy for non-cancer diseases: benefits and long-term risks
CONCLUSIONS: A growing body of evidence has suggested that radiation represents a double-edged sword, not only for cancer, but also for non-cancer diseases. At present, clinical evidence has shown some beneficial effects of radiotherapy for ventricular tachycardia, but there is little or no such evidence of radiotherapy for other newly proposed non-cancer diseases (e.g. Alzheimer's disease, COVID-19 pneumonia). Patients with ventricular tachycardia and COVID-19 pneumonia have thus far been treated with radiotherapy when they are an urgent life threat with no efficient alternative treatment, but some survivors may encounter...
Source: International Journal of Radiation Biology - January 5, 2024 Category: Radiology Authors: Juliette Thariat Mark P Little Lydia B Zablotska Pamela Samson M Kerry O'Banion Klervi Leuraud Carmen Bergom Gilles Girault Omid Azimzadeh Simon Bouffler Nobuyuki Hamada Source Type: research

< em > In utero < /em > exposure to ionizing radiation and metabolic regulation: perspectives for future multi- and trans-generation effects studies
CONCLUSIONS: Knowledge consolidation in the field of Developmental Origins of Health and Disease (DOHaD) has led us to propose a new study strategy. This strategy aims to address the transgenerational effects of in utero exposure to low dose and low dose-rate radiation. Within this concept, there is a possibility that disruption of epigenetic programming in embryonic and fetal cells may occur. This disruption could lead to metabolic dysfunction, which in turn may cause abnormal responses to future environmental challenges, consequently increasing disease risk. Lastly, we discuss methodological limitations in our studies. T...
Source: International Journal of Radiation Biology - January 5, 2024 Category: Radiology Authors: St éphane Grison Ignacia Iii Braga-Tanaka Sarah Baatout Dmitry Klokov Source Type: research

Radiotherapy for non-cancer diseases: benefits and long-term risks
CONCLUSIONS: A growing body of evidence has suggested that radiation represents a double-edged sword, not only for cancer, but also for non-cancer diseases. At present, clinical evidence has shown some beneficial effects of radiotherapy for ventricular tachycardia, but there is little or no such evidence of radiotherapy for other newly proposed non-cancer diseases (e.g. Alzheimer's disease, COVID-19 pneumonia). Patients with ventricular tachycardia and COVID-19 pneumonia have thus far been treated with radiotherapy when they are an urgent life threat with no efficient alternative treatment, but some survivors may encounter...
Source: International Journal of Radiation Biology - January 5, 2024 Category: Radiology Authors: Juliette Thariat Mark P Little Lydia B Zablotska Pamela Samson M Kerry O'Banion Klervi Leuraud Carmen Bergom Gilles Girault Omid Azimzadeh Simon Bouffler Nobuyuki Hamada Source Type: research

< em > In utero < /em > exposure to ionizing radiation and metabolic regulation: perspectives for future multi- and trans-generation effects studies
CONCLUSIONS: Knowledge consolidation in the field of Developmental Origins of Health and Disease (DOHaD) has led us to propose a new study strategy. This strategy aims to address the transgenerational effects of in utero exposure to low dose and low dose-rate radiation. Within this concept, there is a possibility that disruption of epigenetic programming in embryonic and fetal cells may occur. This disruption could lead to metabolic dysfunction, which in turn may cause abnormal responses to future environmental challenges, consequently increasing disease risk. Lastly, we discuss methodological limitations in our studies. T...
Source: International Journal of Radiation Biology - January 5, 2024 Category: Radiology Authors: St éphane Grison Ignacia Iii Braga-Tanaka Sarah Baatout Dmitry Klokov Source Type: research

Nuclear DNA damage-triggered ATM-dependent AMPK activation regulates the mitochondrial radiation response
CONCLUSION: Activation of the AMPK signaling pathway differs depending on the stimulus. Radiation activates AMPK through two pathways: depletion of ATP-mediated LKB1 signaling and nuclear DNA damage-induced ATM signaling. Nuclear DNA damage signaling to mitochondria therefore plays a pivotal role in determining the cell fates of irradiated cells.PMID:38166485 | DOI:10.1080/09553002.2023.2295297 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - January 3, 2024 Category: Radiology Authors: Tsutomu Shimura Kenta Sunaga Mayu Yamazaki Nara Honoka Megumi Sasatani Kenji Kamiya Akira Ushiyama Source Type: research

Stomata damage, photosynthesis, and transpiration evaluation of aquatic lirium after ultrasound irradiation
CONCLUSIONS: The results of structural stomata damage on the ultrasound-irradiated aquatic lirium leaves are consistent with an excessive ultrasound stimulation on stomata's mechanical operation by guard cells that produce the measured significant increase of the photosynthetic and transpiration rates during the first hour after irradiation. The initial high evaporation could alter the water potential gradient, with a possible generation of tensions in the xylem that could cause embolism in their conduits. The loss of xylem conductivity or hydraulic failure would be consistent with the observed significant fall in the phot...
Source: International Journal of Radiation Biology - January 3, 2024 Category: Radiology Authors: Alejandro Rojas Ernesto Hern ández-Rosales Jes ús Montúfar Antonio Gustavo Ju árez-Gracia Uriel Nogal Joel Hern ández-Wong Jos é Bruno Rojas Trigos Ernesto Marin Jos é Antonio Calderón Source Type: research