C. Norman Coleman, M.D. (1945-2024): mentorship, partnership, science, and kindness always
Int J Radiat Biol. 2024 Mar 26:1-3. doi: 10.1080/09553002.2024.2331382. Online ahead of print.NO ABSTRACTPMID:38530806 | DOI:10.1080/09553002.2024.2331382 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 26, 2024 Category: Radiology Authors: Jeffrey C Buchsbaum Frank S Govern Pataje Prasanna Source Type: research

How does ionizing radiation affect amyloidogenesis in plants?
CONCLUSION: Our data hinted that protein accumulation stimulated seedlings' growth as well as accelerated ontogenesis and, eventually, senescence, primarily through translation and RNA processing. The increased abundance of primary metabolism-related proteins indicates more intensive metabolic processes triggered in germinating pea seeds upon X-ray exposure. The functional role of detected putative amyloidogenic proteins should be validated in overexpression or knockout follow-up studies.PMID:38530837 | DOI:10.1080/09553002.2024.2331126 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 26, 2024 Category: Radiology Authors: Maryna Kryvokhyzha Sergii Litvinov Maksym Danchenko Lidiia Khudolieieva Nataliia Kutsokon Peter Bar áth Namik Rashydov Source Type: research

C. Norman Coleman, M.D. (1945-2024): mentorship, partnership, science, and kindness always
Int J Radiat Biol. 2024 Mar 26:1-3. doi: 10.1080/09553002.2024.2331382. Online ahead of print.NO ABSTRACTPMID:38530806 | DOI:10.1080/09553002.2024.2331382 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 26, 2024 Category: Radiology Authors: Jeffrey C Buchsbaum Frank S Govern Pataje Prasanna Source Type: research

How does ionizing radiation affect amyloidogenesis in plants?
CONCLUSION: Our data hinted that protein accumulation stimulated seedlings' growth as well as accelerated ontogenesis and, eventually, senescence, primarily through translation and RNA processing. The increased abundance of primary metabolism-related proteins indicates more intensive metabolic processes triggered in germinating pea seeds upon X-ray exposure. The functional role of detected putative amyloidogenic proteins should be validated in overexpression or knockout follow-up studies.PMID:38530837 | DOI:10.1080/09553002.2024.2331126 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 26, 2024 Category: Radiology Authors: Maryna Kryvokhyzha Sergii Litvinov Maksym Danchenko Lidiia Khudolieieva Nataliia Kutsokon Peter Bar áth Namik Rashydov Source Type: research

C. Norman Coleman, M.D. (1945-2024): mentorship, partnership, science, and kindness always
Int J Radiat Biol. 2024 Mar 26:1-3. doi: 10.1080/09553002.2024.2331382. Online ahead of print.NO ABSTRACTPMID:38530806 | DOI:10.1080/09553002.2024.2331382 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 26, 2024 Category: Radiology Authors: Jeffrey C Buchsbaum Frank S Govern Pataje Prasanna Source Type: research

How does ionizing radiation affect amyloidogenesis in plants?
CONCLUSION: Our data hinted that protein accumulation stimulated seedlings' growth as well as accelerated ontogenesis and, eventually, senescence, primarily through translation and RNA processing. The increased abundance of primary metabolism-related proteins indicates more intensive metabolic processes triggered in germinating pea seeds upon X-ray exposure. The functional role of detected putative amyloidogenic proteins should be validated in overexpression or knockout follow-up studies.PMID:38530837 | DOI:10.1080/09553002.2024.2331126 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 26, 2024 Category: Radiology Authors: Maryna Kryvokhyzha Sergii Litvinov Maksym Danchenko Lidiia Khudolieieva Nataliia Kutsokon Peter Bar áth Namik Rashydov Source Type: research

C. Norman Coleman, M.D. (1945-2024): mentorship, partnership, science, and kindness always
Int J Radiat Biol. 2024 Mar 26:1-3. doi: 10.1080/09553002.2024.2331382. Online ahead of print.NO ABSTRACTPMID:38530806 | DOI:10.1080/09553002.2024.2331382 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 26, 2024 Category: Radiology Authors: Jeffrey C Buchsbaum Frank S Govern Pataje Prasanna Source Type: research

How does ionizing radiation affect amyloidogenesis in plants?
CONCLUSION: Our data hinted that protein accumulation stimulated seedlings' growth as well as accelerated ontogenesis and, eventually, senescence, primarily through translation and RNA processing. The increased abundance of primary metabolism-related proteins indicates more intensive metabolic processes triggered in germinating pea seeds upon X-ray exposure. The functional role of detected putative amyloidogenic proteins should be validated in overexpression or knockout follow-up studies.PMID:38530837 | DOI:10.1080/09553002.2024.2331126 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 26, 2024 Category: Radiology Authors: Maryna Kryvokhyzha Sergii Litvinov Maksym Danchenko Lidiia Khudolieieva Nataliia Kutsokon Peter Bar áth Namik Rashydov Source Type: research

Targeting two radiation-induced immunosuppressive pathways to improve the efficacy of normofractionated radiation therapy in a preclinical colorectal cancer model
CONCLUSIONS: These results tend to demonstrate the interest of inhibiting two radiation-induced immunosuppressive mechanisms. In patients, the combination of normoRT with 5FU is already the standard of care in locally advanced rectal cancer. Adding an anti-PD-L1 to this treatment could show promising results.PMID:38506658 | DOI:10.1080/09553002.2024.2331115 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 20, 2024 Category: Radiology Authors: Jihane Boustani Benoit Lecoester J érémy Baude Charl ène Latour Emeric Limagne Riad Ladjohoulou V éronique Morgand Lisa Froidurot Fran çois Ghiringhelli Gilles Truc Olivier Adot évi C éline Mirjolet Source Type: research

Dietary agents in the prevention of radiation-induced nausea and vomiting (RINV): review addressing the scientific observations, benefits, lacunae and future direction
CONCLUSIONS: Results indicate that Indian pennywort, Sea buckthorn, Spearmint oil and ginger are beneficial in mitigating RINV. Also, of the four plants investigated in preclinical models of study, mint oil and ginger seem to be more useful and merit structured systematic translational studies to ascertain the benefit of these two agents.PMID:38506659 | DOI:10.1080/09553002.2024.2309899 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 20, 2024 Category: Radiology Authors: Princy Louis Palatty Dhanya Sacheendran Shamprasad Varija Raghu Rajesh Arora Suresh Rao Manjeshwar Shrinath Baliga Source Type: research

Epigenetic regulation of TGF- β pathway and its role in radiation response
CONCLUSIONS: By revealing the epigenetic mechanism related to TGF-β-mediated radiation response, summarizing the existing relevant adjuvant strategies for radiotherapy based on TGF-β signaling, and discovering potential therapeutic targets, we hope to provide a new perspective for improving clinical treatment.PMID:38506660 | DOI:10.1080/09553002.2024.2327395 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 20, 2024 Category: Radiology Authors: Yunan Ding Guangming Zhou Wentao Hu Source Type: research

Targeting two radiation-induced immunosuppressive pathways to improve the efficacy of normofractionated radiation therapy in a preclinical colorectal cancer model
CONCLUSIONS: These results tend to demonstrate the interest of inhibiting two radiation-induced immunosuppressive mechanisms. In patients, the combination of normoRT with 5FU is already the standard of care in locally advanced rectal cancer. Adding an anti-PD-L1 to this treatment could show promising results.PMID:38506658 | DOI:10.1080/09553002.2024.2331115 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 20, 2024 Category: Radiology Authors: Jihane Boustani Benoit Lecoester J érémy Baude Charl ène Latour Emeric Limagne Riad Ladjohoulou V éronique Morgand Lisa Froidurot Fran çois Ghiringhelli Gilles Truc Olivier Adot évi C éline Mirjolet Source Type: research

Dietary agents in the prevention of radiation-induced nausea and vomiting (RINV): review addressing the scientific observations, benefits, lacunae and future direction
CONCLUSIONS: Results indicate that Indian pennywort, Sea buckthorn, Spearmint oil and ginger are beneficial in mitigating RINV. Also, of the four plants investigated in preclinical models of study, mint oil and ginger seem to be more useful and merit structured systematic translational studies to ascertain the benefit of these two agents.PMID:38506659 | DOI:10.1080/09553002.2024.2309899 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 20, 2024 Category: Radiology Authors: Princy Louis Palatty Dhanya Sacheendran Shamprasad Varija Raghu Rajesh Arora Suresh Rao Manjeshwar Shrinath Baliga Source Type: research

Epigenetic regulation of TGF- β pathway and its role in radiation response
CONCLUSIONS: By revealing the epigenetic mechanism related to TGF-β-mediated radiation response, summarizing the existing relevant adjuvant strategies for radiotherapy based on TGF-β signaling, and discovering potential therapeutic targets, we hope to provide a new perspective for improving clinical treatment.PMID:38506660 | DOI:10.1080/09553002.2024.2327395 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 20, 2024 Category: Radiology Authors: Yunan Ding Guangming Zhou Wentao Hu Source Type: research

Targeting two radiation-induced immunosuppressive pathways to improve the efficacy of normofractionated radiation therapy in a preclinical colorectal cancer model
CONCLUSIONS: These results tend to demonstrate the interest of inhibiting two radiation-induced immunosuppressive mechanisms. In patients, the combination of normoRT with 5FU is already the standard of care in locally advanced rectal cancer. Adding an anti-PD-L1 to this treatment could show promising results.PMID:38506658 | DOI:10.1080/09553002.2024.2331115 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 20, 2024 Category: Radiology Authors: Jihane Boustani Benoit Lecoester J érémy Baude Charl ène Latour Emeric Limagne Riad Ladjohoulou V éronique Morgand Lisa Froidurot Fran çois Ghiringhelli Gilles Truc Olivier Adot évi C éline Mirjolet Source Type: research