Targeting two radiation-induced immunosuppressive pathways to improve the efficacy of normofractionated radiation therapy in a preclinical colorectal cancer model

CONCLUSIONS: These results tend to demonstrate the interest of inhibiting two radiation-induced immunosuppressive mechanisms. In patients, the combination of normoRT with 5FU is already the standard of care in locally advanced rectal cancer. Adding an anti-PD-L1 to this treatment could show promising results.PMID:38506658 | DOI:10.1080/09553002.2024.2331115

Source: International Journal of Radiation Biology - March 20, 2024 Category: Radiology Authors: Jihane Boustani Benoit Lecoester J érémy Baude Charl ène Latour Emeric Limagne Riad Ladjohoulou V éronique Morgand Lisa Froidurot Fran çois Ghiringhelli Gilles Truc Olivier Adot évi C éline Mirjolet Source Type: research