microRNA silencing in a whole worm cestode model provides insight into miR-71 function
This study provides new knowledge on gene expression regulation in cestodes and suggests that miRNAs could be evaluated as new selective therapeutic targets for treating Neglected Tropical Diseases prioritised by the World Health Organization.PMID:37699506 | DOI:10.1016/j.ijpara.2023.08.002 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - September 12, 2023 Category: Parasitology Authors: Andr és Grecco Natalia Macchiaroli Mat ías Pérez Adriano Casulli Marcela Cucher Mara Cecilia Rosenzvit Source Type: research

microRNA silencing in a whole worm cestode model provides insight into miR-71 function
This study provides new knowledge on gene expression regulation in cestodes and suggests that miRNAs could be evaluated as new selective therapeutic targets for treating Neglected Tropical Diseases prioritised by the World Health Organization.PMID:37699506 | DOI:10.1016/j.ijpara.2023.08.002 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - September 12, 2023 Category: Parasitology Authors: Andr és Grecco Natalia Macchiaroli Mat ías Pérez Adriano Casulli Marcela Cucher Mara Cecilia Rosenzvit Source Type: research

microRNA silencing in a whole worm cestode model provides insight into miR-71 function
This study provides new knowledge on gene expression regulation in cestodes and suggests that miRNAs could be evaluated as new selective therapeutic targets for treating Neglected Tropical Diseases prioritised by the World Health Organization.PMID:37699506 | DOI:10.1016/j.ijpara.2023.08.002 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - September 12, 2023 Category: Parasitology Authors: Andr és Grecco Natalia Macchiaroli Mat ías Pérez Adriano Casulli Marcela Cucher Mara Cecilia Rosenzvit Source Type: research

microRNA silencing in a whole worm cestode model provides insight into miR-71 function
This study provides new knowledge on gene expression regulation in cestodes and suggests that miRNAs could be evaluated as new selective therapeutic targets for treating Neglected Tropical Diseases prioritised by the World Health Organization.PMID:37699506 | DOI:10.1016/j.ijpara.2023.08.002 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - September 12, 2023 Category: Parasitology Authors: Andr és Grecco Natalia Macchiaroli Mat ías Pérez Adriano Casulli Marcela Cucher Mara Cecilia Rosenzvit Source Type: research

microRNA silencing in a whole worm cestode model provides insight into miR-71 function
This study provides new knowledge on gene expression regulation in cestodes and suggests that miRNAs could be evaluated as new selective therapeutic targets for treating Neglected Tropical Diseases prioritised by the World Health Organization.PMID:37699506 | DOI:10.1016/j.ijpara.2023.08.002 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - September 12, 2023 Category: Parasitology Authors: Andr és Grecco Natalia Macchiaroli Mat ías Pérez Adriano Casulli Marcela Cucher Mara Cecilia Rosenzvit Source Type: research

Abomasal RNA-seq reveals a strong local cellular response in suckling lambs with resistance against Haemonchus contortus
In this study, we sequenced the polyadenylated RNA of the abomasal tissue of SI and IF suckling lambs to identify mucosa-specific transcript alterations between breeds artificially infected with H. contortus. Naïve SI (n=4) and IF (n=4) lambs were artificially infected every other day, over a period of 52 days, from 14 to 66 days old, with a total of 5,400 H. contortus infective larvae. Fundic abomasal tissue samples were collected at 68 days old, and submitted to high-throughput RNA sequencing (RNA-seq). Differential expression analysis (P value < 0.001 and False Discovery Rate (FDR) < 0.05) between SI and IF sampl...
Source: International Journal for Parasitology - September 6, 2023 Category: Parasitology Authors: Jos é Gabriel Gonçalves Lins Ana Cl áudia Alexandre de Albuquerque Fabiana Alves de Almeida Collette Britton Camila Malossi Jo ão Pessoa de Araújo-Júnior Helder Louvandini Alessandro F T Amarante Source Type: research

Abomasal RNA-seq reveals a strong local cellular response in suckling lambs with resistance against Haemonchus contortus
In this study, we sequenced the polyadenylated RNA of the abomasal tissue of SI and IF suckling lambs to identify mucosa-specific transcript alterations between breeds artificially infected with H. contortus. Naïve SI (n=4) and IF (n=4) lambs were artificially infected every other day, over a period of 52 days, from 14 to 66 days old, with a total of 5,400 H. contortus infective larvae. Fundic abomasal tissue samples were collected at 68 days old, and submitted to high-throughput RNA sequencing (RNA-seq). Differential expression analysis (P value < 0.001 and False Discovery Rate (FDR) < 0.05) between SI and IF sampl...
Source: International Journal for Parasitology - September 6, 2023 Category: Parasitology Authors: Jos é Gabriel Gonçalves Lins Ana Cl áudia Alexandre de Albuquerque Fabiana Alves de Almeida Collette Britton Camila Malossi Jo ão Pessoa de Araújo-Júnior Helder Louvandini Alessandro F T Amarante Source Type: research

Abomasal RNA-seq reveals a strong local cellular response in suckling lambs with resistance against Haemonchus contortus
In this study, we sequenced the polyadenylated RNA of the abomasal tissue of SI and IF suckling lambs to identify mucosa-specific transcript alterations between breeds artificially infected with H. contortus. Naïve SI (n=4) and IF (n=4) lambs were artificially infected every other day, over a period of 52 days, from 14 to 66 days old, with a total of 5,400 H. contortus infective larvae. Fundic abomasal tissue samples were collected at 68 days old, and submitted to high-throughput RNA sequencing (RNA-seq). Differential expression analysis (P value < 0.001 and False Discovery Rate (FDR) < 0.05) between SI and IF sampl...
Source: International Journal for Parasitology - September 6, 2023 Category: Parasitology Authors: Jos é Gabriel Gonçalves Lins Ana Cl áudia Alexandre de Albuquerque Fabiana Alves de Almeida Collette Britton Camila Malossi Jo ão Pessoa de Araújo-Júnior Helder Louvandini Alessandro F T Amarante Source Type: research

Abomasal RNA-seq reveals a strong local cellular response in suckling lambs with resistance against Haemonchus contortus
In this study, we sequenced the polyadenylated RNA of the abomasal tissue of SI and IF suckling lambs to identify mucosa-specific transcript alterations between breeds artificially infected with H. contortus. Naïve SI (n=4) and IF (n=4) lambs were artificially infected every other day, over a period of 52 days, from 14 to 66 days old, with a total of 5,400 H. contortus infective larvae. Fundic abomasal tissue samples were collected at 68 days old, and submitted to high-throughput RNA sequencing (RNA-seq). Differential expression analysis (P value < 0.001 and False Discovery Rate (FDR) < 0.05) between SI and IF sampl...
Source: International Journal for Parasitology - September 6, 2023 Category: Parasitology Authors: Jos é Gabriel Gonçalves Lins Ana Cl áudia Alexandre de Albuquerque Fabiana Alves de Almeida Collette Britton Camila Malossi Jo ão Pessoa de Araújo-Júnior Helder Louvandini Alessandro F T Amarante Source Type: research

Abomasal RNA-seq reveals a strong local cellular response in suckling lambs with resistance against Haemonchus contortus
In this study, we sequenced the polyadenylated RNA of the abomasal tissue of SI and IF suckling lambs to identify mucosa-specific transcript alterations between breeds artificially infected with H. contortus. Naïve SI (n=4) and IF (n=4) lambs were artificially infected every other day, over a period of 52 days, from 14 to 66 days old, with a total of 5,400 H. contortus infective larvae. Fundic abomasal tissue samples were collected at 68 days old, and submitted to high-throughput RNA sequencing (RNA-seq). Differential expression analysis (P value < 0.001 and False Discovery Rate (FDR) < 0.05) between SI and IF sampl...
Source: International Journal for Parasitology - September 6, 2023 Category: Parasitology Authors: Jos é Gabriel Gonçalves Lins Ana Cl áudia Alexandre de Albuquerque Fabiana Alves de Almeida Collette Britton Camila Malossi Jo ão Pessoa de Araújo-Júnior Helder Louvandini Alessandro F T Amarante Source Type: research

The same genotype of Sarcocystis neurona responsible for mass mortality in marine mammals induced a clinical outbreak in raccoons (Procyon lotor) 10 years later
This study reports the following new genotyping markers at 18S rRNA, 28S rRNA, COX1, ITS-1, RON1, RON2, GAPDH1, ROP20, SAG2, SnSRS21 and TUBA1 markers. The identity of Sarcocystis spp. infecting raccoons is discussed.PMID:37652223 | DOI:10.1016/j.ijpara.2023.08.001 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - August 31, 2023 Category: Parasitology Authors: Aditya Gupta Mary Duncan Amy R Sweeny Larissa S de Araujo Oliver C H Kwok Benjamin M Rosenthal Asis Khan Michael E Grigg Jitender P Dubey Source Type: research

Genome structure and population genomics of the canine heartworm Dirofilaria immitis
This study aimed to improve the genomic resources of D. immitis to enable a more precise understanding of how genetic variation is distributed within and between parasite populations worldwide, which will inform the likelihood and rate by which parasites, and in turn, resistant alleles, might spread. We have guided the scaffolding of a recently published genome assembly for D. immitis (ICBAS_JMDir_1.0) using the chromosomal-scale reference genomes of Brugia malayi and Onchocerca volvulus, resulting in an 89.5 Mb assembly composed of four autosomal- and one sex-linked chromosomal-scale scaffolds representing 99.7% of the ge...
Source: International Journal for Parasitology - August 31, 2023 Category: Parasitology Authors: Javier Gandasegui Rosemonde I Power Emily Curry Daisy Ching-Wai Lau Connor M O'Neill Adrian Wolstenholme Roger Prichard Jan Šlapeta Stephen R Doyle Source Type: research

The same genotype of Sarcocystis neurona responsible for mass mortality in marine mammals induced a clinical outbreak in raccoons (Procyon lotor) 10 years later
This study reports the following new genotyping markers at 18S rRNA, 28S rRNA, COX1, ITS-1, RON1, RON2, GAPDH1, ROP20, SAG2, SnSRS21 and TUBA1 markers. The identity of Sarcocystis spp. infecting raccoons is discussed.PMID:37652223 | DOI:10.1016/j.ijpara.2023.08.001 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - August 31, 2023 Category: Parasitology Authors: Aditya Gupta Mary Duncan Amy R Sweeny Larissa S de Araujo Oliver C H Kwok Benjamin M Rosenthal Asis Khan Michael E Grigg Jitender P Dubey Source Type: research

Genome structure and population genomics of the canine heartworm Dirofilaria immitis
This study aimed to improve the genomic resources of D. immitis to enable a more precise understanding of how genetic variation is distributed within and between parasite populations worldwide, which will inform the likelihood and rate by which parasites, and in turn, resistant alleles, might spread. We have guided the scaffolding of a recently published genome assembly for D. immitis (ICBAS_JMDir_1.0) using the chromosomal-scale reference genomes of Brugia malayi and Onchocerca volvulus, resulting in an 89.5 Mb assembly composed of four autosomal- and one sex-linked chromosomal-scale scaffolds representing 99.7% of the ge...
Source: International Journal for Parasitology - August 31, 2023 Category: Parasitology Authors: Javier Gandasegui Rosemonde I Power Emily Curry Daisy Ching-Wai Lau Connor M O'Neill Adrian Wolstenholme Roger Prichard Jan Šlapeta Stephen R Doyle Source Type: research

The same genotype of Sarcocystis neurona responsible for mass mortality in marine mammals induced a clinical outbreak in raccoons (Procyon lotor) 10 years later
This study reports the following new genotyping markers at 18S rRNA, 28S rRNA, COX1, ITS-1, RON1, RON2, GAPDH1, ROP20, SAG2, SnSRS21 and TUBA1 markers. The identity of Sarcocystis spp. infecting raccoons is discussed.PMID:37652223 | DOI:10.1016/j.ijpara.2023.08.001 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - August 31, 2023 Category: Parasitology Authors: Aditya Gupta Mary Duncan Amy R Sweeny Larissa S de Araujo Oliver C H Kwok Benjamin M Rosenthal Asis Khan Michael E Grigg Jitender P Dubey Source Type: research