International Journal for Parasitology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Comparative genomics analysis reveals sequence characteristics potentially related to host preference in Cryptosporidium xiaoi
In this study, we sequenced the genomes of two C. xiaoi isolates and performed comparative genomic analysis to identify the sequence uniqueness of this ovine-adapted species compared with other Cryptosporidium spp. Our results showed that C. xiaoi is genetically related to C. bovis as shown by their 95.8% genomic identity and similar gene content. Consistent with this, both C. xiaoi and C. bovis appear to have fewer genes encoding mitochondrial metabolic enzymes and invasion-related protein families. However, they appear to possess several species-specific genes. Further analysis indicates that the sequence differences bet...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Jiayu Li Yingying Fan Na Li Yaqiong Guo Weijian Wang Kangli Feng Wei He Falei Li Jianbo Huang Yanhua Xu Lihua Xiao Yaoyu Feng Source Type: research

The unusual kinetics of lactate dehydrogenase of Schistosoma mansoni and their role in the rapid metabolic switch after penetration of the mammalian host
Int J Parasitol. 2024 Mar 14:S0020-7519(24)00054-7. doi: 10.1016/j.ijpara.2024.03.005. Online ahead of print.ABSTRACTLactate dehydrogenase (LDH) from Schistosoma mansoni has peculiar properties for a eukaryotic LDH. Schistosomal LDH (SmLDH) isolated from schistosomes, and the recombinantly expressed protein, are strongly inhibited by ATP, which is neutralized by fructose-1,6-bisphosphate (FBP). In the conserved FBP/anion binding site we identified two residues in SmLDH (Val187 and Tyr190) that differ from the conserved residues in LDHs of other eukaryotes, but are identical to conserved residues in FBP-sensitive prokaryoti...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Michiel L Bexkens Olivier M F Martin Jos M van den Heuvel Marion G J Schmitz Bas Teusink Barbara M Bakker Jaap J van Hellemond Jurgen R Haanstra Malcolm D Walkinshaw Aloysius G M Tielens Source Type: research

Comparative genomics analysis reveals sequence characteristics potentially related to host preference in Cryptosporidium xiaoi
In this study, we sequenced the genomes of two C. xiaoi isolates and performed comparative genomic analysis to identify the sequence uniqueness of this ovine-adapted species compared with other Cryptosporidium spp. Our results showed that C. xiaoi is genetically related to C. bovis as shown by their 95.8% genomic identity and similar gene content. Consistent with this, both C. xiaoi and C. bovis appear to have fewer genes encoding mitochondrial metabolic enzymes and invasion-related protein families. However, they appear to possess several species-specific genes. Further analysis indicates that the sequence differences bet...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Jiayu Li Yingying Fan Na Li Yaqiong Guo Weijian Wang Kangli Feng Wei He Falei Li Jianbo Huang Yanhua Xu Lihua Xiao Yaoyu Feng Source Type: research

The unusual kinetics of lactate dehydrogenase of Schistosoma mansoni and their role in the rapid metabolic switch after penetration of the mammalian host
Int J Parasitol. 2024 Mar 14:S0020-7519(24)00054-7. doi: 10.1016/j.ijpara.2024.03.005. Online ahead of print.ABSTRACTLactate dehydrogenase (LDH) from Schistosoma mansoni has peculiar properties for a eukaryotic LDH. Schistosomal LDH (SmLDH) isolated from schistosomes, and the recombinantly expressed protein, are strongly inhibited by ATP, which is neutralized by fructose-1,6-bisphosphate (FBP). In the conserved FBP/anion binding site we identified two residues in SmLDH (Val187 and Tyr190) that differ from the conserved residues in LDHs of other eukaryotes, but are identical to conserved residues in FBP-sensitive prokaryoti...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Michiel L Bexkens Olivier M F Martin Jos M van den Heuvel Marion G J Schmitz Bas Teusink Barbara M Bakker Jaap J van Hellemond Jurgen R Haanstra Malcolm D Walkinshaw Aloysius G M Tielens Source Type: research

Comparative genomics analysis reveals sequence characteristics potentially related to host preference in Cryptosporidium xiaoi
In this study, we sequenced the genomes of two C. xiaoi isolates and performed comparative genomic analysis to identify the sequence uniqueness of this ovine-adapted species compared with other Cryptosporidium spp. Our results showed that C. xiaoi is genetically related to C. bovis as shown by their 95.8% genomic identity and similar gene content. Consistent with this, both C. xiaoi and C. bovis appear to have fewer genes encoding mitochondrial metabolic enzymes and invasion-related protein families. However, they appear to possess several species-specific genes. Further analysis indicates that the sequence differences bet...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Jiayu Li Yingying Fan Na Li Yaqiong Guo Weijian Wang Kangli Feng Wei He Falei Li Jianbo Huang Yanhua Xu Lihua Xiao Yaoyu Feng Source Type: research

The unusual kinetics of lactate dehydrogenase of Schistosoma mansoni and their role in the rapid metabolic switch after penetration of the mammalian host
Int J Parasitol. 2024 Mar 14:S0020-7519(24)00054-7. doi: 10.1016/j.ijpara.2024.03.005. Online ahead of print.ABSTRACTLactate dehydrogenase (LDH) from Schistosoma mansoni has peculiar properties for a eukaryotic LDH. Schistosomal LDH (SmLDH) isolated from schistosomes, and the recombinantly expressed protein, are strongly inhibited by ATP, which is neutralized by fructose-1,6-bisphosphate (FBP). In the conserved FBP/anion binding site we identified two residues in SmLDH (Val187 and Tyr190) that differ from the conserved residues in LDHs of other eukaryotes, but are identical to conserved residues in FBP-sensitive prokaryoti...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Michiel L Bexkens Olivier M F Martin Jos M van den Heuvel Marion G J Schmitz Bas Teusink Barbara M Bakker Jaap J van Hellemond Jurgen R Haanstra Malcolm D Walkinshaw Aloysius G M Tielens Source Type: research

Comparative genomics analysis reveals sequence characteristics potentially related to host preference in Cryptosporidium xiaoi
In this study, we sequenced the genomes of two C. xiaoi isolates and performed comparative genomic analysis to identify the sequence uniqueness of this ovine-adapted species compared with other Cryptosporidium spp. Our results showed that C. xiaoi is genetically related to C. bovis as shown by their 95.8% genomic identity and similar gene content. Consistent with this, both C. xiaoi and C. bovis appear to have fewer genes encoding mitochondrial metabolic enzymes and invasion-related protein families. However, they appear to possess several species-specific genes. Further analysis indicates that the sequence differences bet...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Jiayu Li Yingying Fan Na Li Yaqiong Guo Weijian Wang Kangli Feng Wei He Falei Li Jianbo Huang Yanhua Xu Lihua Xiao Yaoyu Feng Source Type: research

The unusual kinetics of lactate dehydrogenase of Schistosoma mansoni and their role in the rapid metabolic switch after penetration of the mammalian host
Int J Parasitol. 2024 Mar 14:S0020-7519(24)00054-7. doi: 10.1016/j.ijpara.2024.03.005. Online ahead of print.ABSTRACTLactate dehydrogenase (LDH) from Schistosoma mansoni has peculiar properties for a eukaryotic LDH. Schistosomal LDH (SmLDH) isolated from schistosomes, and the recombinantly expressed protein, are strongly inhibited by ATP, which is neutralized by fructose-1,6-bisphosphate (FBP). In the conserved FBP/anion binding site we identified two residues in SmLDH (Val187 and Tyr190) that differ from the conserved residues in LDHs of other eukaryotes, but are identical to conserved residues in FBP-sensitive prokaryoti...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Michiel L Bexkens Olivier M F Martin Jos M van den Heuvel Marion G J Schmitz Bas Teusink Barbara M Bakker Jaap J van Hellemond Jurgen R Haanstra Malcolm D Walkinshaw Aloysius G M Tielens Source Type: research

Comparative genomics analysis reveals sequence characteristics potentially related to host preference in Cryptosporidium xiaoi
In this study, we sequenced the genomes of two C. xiaoi isolates and performed comparative genomic analysis to identify the sequence uniqueness of this ovine-adapted species compared with other Cryptosporidium spp. Our results showed that C. xiaoi is genetically related to C. bovis as shown by their 95.8% genomic identity and similar gene content. Consistent with this, both C. xiaoi and C. bovis appear to have fewer genes encoding mitochondrial metabolic enzymes and invasion-related protein families. However, they appear to possess several species-specific genes. Further analysis indicates that the sequence differences bet...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Jiayu Li Yingying Fan Na Li Yaqiong Guo Weijian Wang Kangli Feng Wei He Falei Li Jianbo Huang Yanhua Xu Lihua Xiao Yaoyu Feng Source Type: research

The unusual kinetics of lactate dehydrogenase of Schistosoma mansoni and their role in the rapid metabolic switch after penetration of the mammalian host
Int J Parasitol. 2024 Mar 14:S0020-7519(24)00054-7. doi: 10.1016/j.ijpara.2024.03.005. Online ahead of print.ABSTRACTLactate dehydrogenase (LDH) from Schistosoma mansoni has peculiar properties for a eukaryotic LDH. Schistosomal LDH (SmLDH) isolated from schistosomes, and the recombinantly expressed protein, are strongly inhibited by ATP, which is neutralized by fructose-1,6-bisphosphate (FBP). In the conserved FBP/anion binding site we identified two residues in SmLDH (Val187 and Tyr190) that differ from the conserved residues in LDHs of other eukaryotes, but are identical to conserved residues in FBP-sensitive prokaryoti...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Michiel L Bexkens Olivier M F Martin Jos M van den Heuvel Marion G J Schmitz Bas Teusink Barbara M Bakker Jaap J van Hellemond Jurgen R Haanstra Malcolm D Walkinshaw Aloysius G M Tielens Source Type: research

Comparative genomics analysis reveals sequence characteristics potentially related to host preference in Cryptosporidium xiaoi
In this study, we sequenced the genomes of two C. xiaoi isolates and performed comparative genomic analysis to identify the sequence uniqueness of this ovine-adapted species compared with other Cryptosporidium spp. Our results showed that C. xiaoi is genetically related to C. bovis as shown by their 95.8% genomic identity and similar gene content. Consistent with this, both C. xiaoi and C. bovis appear to have fewer genes encoding mitochondrial metabolic enzymes and invasion-related protein families. However, they appear to possess several species-specific genes. Further analysis indicates that the sequence differences bet...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Jiayu Li Yingying Fan Na Li Yaqiong Guo Weijian Wang Kangli Feng Wei He Falei Li Jianbo Huang Yanhua Xu Lihua Xiao Yaoyu Feng Source Type: research

The unusual kinetics of lactate dehydrogenase of Schistosoma mansoni and their role in the rapid metabolic switch after penetration of the mammalian host
Int J Parasitol. 2024 Mar 14:S0020-7519(24)00054-7. doi: 10.1016/j.ijpara.2024.03.005. Online ahead of print.ABSTRACTLactate dehydrogenase (LDH) from Schistosoma mansoni has peculiar properties for a eukaryotic LDH. Schistosomal LDH (SmLDH) isolated from schistosomes, and the recombinantly expressed protein, are strongly inhibited by ATP, which is neutralized by fructose-1,6-bisphosphate (FBP). In the conserved FBP/anion binding site we identified two residues in SmLDH (Val187 and Tyr190) that differ from the conserved residues in LDHs of other eukaryotes, but are identical to conserved residues in FBP-sensitive prokaryoti...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Michiel L Bexkens Olivier M F Martin Jos M van den Heuvel Marion G J Schmitz Bas Teusink Barbara M Bakker Jaap J van Hellemond Jurgen R Haanstra Malcolm D Walkinshaw Aloysius G M Tielens Source Type: research

Comparative genomics analysis reveals sequence characteristics potentially related to host preference in Cryptosporidium xiaoi
In this study, we sequenced the genomes of two C. xiaoi isolates and performed comparative genomic analysis to identify the sequence uniqueness of this ovine-adapted species compared with other Cryptosporidium spp. Our results showed that C. xiaoi is genetically related to C. bovis as shown by their 95.8% genomic identity and similar gene content. Consistent with this, both C. xiaoi and C. bovis appear to have fewer genes encoding mitochondrial metabolic enzymes and invasion-related protein families. However, they appear to possess several species-specific genes. Further analysis indicates that the sequence differences bet...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Jiayu Li Yingying Fan Na Li Yaqiong Guo Weijian Wang Kangli Feng Wei He Falei Li Jianbo Huang Yanhua Xu Lihua Xiao Yaoyu Feng Source Type: research

The unusual kinetics of lactate dehydrogenase of Schistosoma mansoni and their role in the rapid metabolic switch after penetration of the mammalian host
Int J Parasitol. 2024 Mar 14:S0020-7519(24)00054-7. doi: 10.1016/j.ijpara.2024.03.005. Online ahead of print.ABSTRACTLactate dehydrogenase (LDH) from Schistosoma mansoni has peculiar properties for a eukaryotic LDH. Schistosomal LDH (SmLDH) isolated from schistosomes, and the recombinantly expressed protein, are strongly inhibited by ATP, which is neutralized by fructose-1,6-bisphosphate (FBP). In the conserved FBP/anion binding site we identified two residues in SmLDH (Val187 and Tyr190) that differ from the conserved residues in LDHs of other eukaryotes, but are identical to conserved residues in FBP-sensitive prokaryoti...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Michiel L Bexkens Olivier M F Martin Jos M van den Heuvel Marion G J Schmitz Bas Teusink Barbara M Bakker Jaap J van Hellemond Jurgen R Haanstra Malcolm D Walkinshaw Aloysius G M Tielens Source Type: research

Comparative genomics analysis reveals sequence characteristics potentially related to host preference in Cryptosporidium xiaoi
In this study, we sequenced the genomes of two C. xiaoi isolates and performed comparative genomic analysis to identify the sequence uniqueness of this ovine-adapted species compared with other Cryptosporidium spp. Our results showed that C. xiaoi is genetically related to C. bovis as shown by their 95.8% genomic identity and similar gene content. Consistent with this, both C. xiaoi and C. bovis appear to have fewer genes encoding mitochondrial metabolic enzymes and invasion-related protein families. However, they appear to possess several species-specific genes. Further analysis indicates that the sequence differences bet...
Source: International Journal for Parasitology - March 16, 2024 Category: Parasitology Authors: Jiayu Li Yingying Fan Na Li Yaqiong Guo Weijian Wang Kangli Feng Wei He Falei Li Jianbo Huang Yanhua Xu Lihua Xiao Yaoyu Feng Source Type: research