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Unraveling the Mystery of Polyvalent Immunoglobulins in Belgium: Do We Have an Indication?
Conclusion: Our research offers the first comprehensive overview on Ig use in Belgium, including a detailed description of reimbursed use, as well as approximations to off-label use. In view of increasing pressure on Ig availability, better understanding Ig needs and trends, would benefit from an effective indication-specific national registry system (ideally covering both reimbursed and nonreimbursed use).Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - June 30, 2021 Category: Allergy & Immunology Source Type: research

Evaluation of the Clinical and Laboratory Findings of Asthmatic Children with SARS-CoV-2 Infection
Conclusion: This study revealed that pediatric patients diagnosed with asthma were in a mild clinic. According to these findings, asthma may not affect the course of the COVID-19 in children.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - June 24, 2021 Category: Allergy & Immunology Source Type: research

Downregulation of < b > < i > ITM2A < /i > < /b > Gene Expression in Macrophages of Patients with Ankylosing Spondylitis
Conclusion: SinceITM2A plays a critical role in osteo- and chondrogenic cellular differentiation, our finding may provide new insights into AS pathogenesis.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - June 23, 2021 Category: Allergy & Immunology Source Type: research

Upregulation of Basonuclin1 Is Associated with p63-Involved Epithelial Barrier Impairment and Type-2 Helper T-cell Inflammation in Chronic Rhinosinusitis with Nasal Polyps
Conclusions: Overexpression ofBNC1 may be associated with increased expression ofTP63, and possibly contribute to the epithelial barrier defects and TH2 inflammation in CRSwNP.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - June 18, 2021 Category: Allergy & Immunology Source Type: research

Obesity and Asthma: An Intriguing Link in Childhood and Adolescence
Conclusion: This study showed that body weight did not affect asthma control and lung function in a large population of children and adolescents with asthma followed in Italian tertiary allergy/asthma centers and adequately managed.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - June 18, 2021 Category: Allergy & Immunology Source Type: research

Establishment of Rat Models of Different Pathological Types of Hypersensitivity Pneumonitis Using Pigeon Droppings
Conclusions: Both aerosol inhalation and airway instillation of freeze-dried pigeon allergen powder can successfully establish an HP model. The airway instillation method can cause pulmonary fibrotic changes in a short time, and the pulmonary pathological changes of animal models manifest with an obvious time-dose effect.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - June 17, 2021 Category: Allergy & Immunology Source Type: research

Serum Human β-Defensin 2 Is Increased in Angioedema Accompanying Chronic Spontaneous Urticaria
Conclusion: A known mast-cell degranulator, HBD2 was elevated in the sera from CSU patients compared to healthy controls and may be involved in the pathogenesis of accompanying angioedema.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - June 17, 2021 Category: Allergy & Immunology Source Type: research

Erratum
Int Arch Allergy Immunol 2021;182:1 (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - June 8, 2021 Category: Allergy & Immunology Source Type: research

Clinical Relevance of Shrimp Sensitization in Patients with Allergic Rhinitis: Anti-Der p 10 IgE as Predictor
Conclusion: Our results suggest that in patients with HDM-associated AR and shrimp IgE sensitization is necessary to evaluate the clinical relevance of shrimp IgE even if the patient has never consumed shrimp because of cross-reactivity. Anti-Der p 10 could be a possible biomarker of clinical relevance to shrimp sensitization and could reduce the need for OCTs.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - June 4, 2021 Category: Allergy & Immunology Source Type: research

MP-AzeFlu in Moderate-to-Severe Allergic Rhinitis: A Literature Review
Allergic rhinitis (AR) is prevalent, and many patients present with moderate-to-severe symptomatic disease. The majority of patients are not satisfied with their AR treatment, despite the use of concurrent medications. These gaps underscore the need for treatment with more effective options for moderate-to-severe AR. The authors ’ objective was to review systematically the efficacy and safety of MP-AzeFlu for the treatment of AR. The primary outcomes studied were nasal, ocular, and total symptoms. Other outcomes included time to onset and of AR control, quality of life, and safety. Searches of PubMed and Cochrane databas...
Source: International Archives of Allergy and Immunology - June 3, 2021 Category: Allergy & Immunology Source Type: research

Evaluation of Hypersensitivity Reactions in Pediatric Patients Using Biological Drugs
Conclusion: It was reported that 6.64% of the patients who received biologic drug therapy for various reasons in our hospital had hypersensitivity. The most common culprit agent was rituximab, and most of the reactions were immediate reactions.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - June 3, 2021 Category: Allergy & Immunology Source Type: research

Metabolism of Epithelial Cells in Health and Allergic Disease: Collegium Internationale Allergologicum Update 2021
Concomitant dramatic increase in prevalence of allergic and metabolic diseases is part of a modern epidemic afflicting technologically advanced societies. While clinical evidence points to clear associations between various metabolic factors and atopic disease, there is still a very limited understanding of the mechanisms that link the two. Dysregulation of central metabolism in metabolic syndrome, obesity, diabetes, and dyslipidemia has a systemic impact on multiple tissues and organs, including cells of the epithelial barrier. While much of epithelial research in allergy has focused on the immune-driven processes, a grow...
Source: International Archives of Allergy and Immunology - June 2, 2021 Category: Allergy & Immunology Source Type: research

Ligand-Regulated Expression of TNF Receptors 1 and 2 Determines Receptor-Mediated Functional Responses
Conclusions: High expression of TNF receptor type 1 is not always associated with predominant activation of proapoptotic pathways. However, in the case of simultaneous high expression of both types of receptors, the proportion of double-positive cells is crucial for the activation of either the proapoptotic or proliferation pathways.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - June 1, 2021 Category: Allergy & Immunology Source Type: research

An Algorithmic Approach for Allergy Testing in Exclusively Breastfed Infants with Atopic Dermatitis
Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - June 1, 2021 Category: Allergy & Immunology Source Type: research

The Prevalence of Atopic Manifestations in 313 Iranian Patients with Inborn Errors of Immunity
Conclusion: Atopic diseases may contribute to the clinical picture of IEIs, particularly in patients with CID. Atopy in association with other warning signs of IEIs increases the possibility of an underlying IEI.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - May 31, 2021 Category: Allergy & Immunology Source Type: research