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Clinical Features of Wheat Allergy Are Significantly Different between Tri a 14 Sensitized Patients and Tri a 19 Sensitized Ones
Conclusions: Sensitization to Tri a 19 or Tri a 14 determines different clinical pictures. In particular, sensitization to Tri a 19 implies a higher probability of severe reactions, even dependent on daily triggers, while that to Tri a 14 implies a higher cross-reactivity with other foods but it ’s more frequently asymptomatic, making a food challenge necessary to prevent useless food avoidance.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 20, 2021 Category: Allergy & Immunology Source Type: research

Assessment of the Ovarian Reserve by Serum Anti-M üllerian Hormone in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis
Conclusion: The results indicated that there was an increased risk of ovarian failure in RA patients and which is not related to DMARD treatment.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 20, 2021 Category: Allergy & Immunology Source Type: research

Erratum
Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 20, 2021 Category: Allergy & Immunology Source Type: research

Impact of Penicillin Allergy Label on Length of Stay and Mortality in Hospitalized Patients through a Clinical Administrative National Dataset
Conclusion: In our study, the prevalence of a penicillin allergy label in hospitalized patients, using the MBDS, is low. Hospitalizations with an allergy label was associated with a longer LOHS. However, penicillin-allergic patients did not show higher mortality rates. Inaccurate reporting of penicillin allergies may have an impact on healthcare resources.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 17, 2021 Category: Allergy & Immunology Source Type: research

CircRNAPTK2 Promotes Cardiomyocyte Apoptosis in Septic Mice by Competitively Binding to miR-29b-3p with BAK1
Conclusion: CircPTK2 is overexpressed in the myocardium of septic mice. CircPTK2 competitively bound to miR-29b-3p to upregulate BAK1 mRNA level, to promote cardiomyocyte apoptosis, inflammatory response, and myocardial damage of the myocardium of septic mice.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 16, 2021 Category: Allergy & Immunology Source Type: research

A Simple and Rapid Light-Initiated Chemiluminescence Assay for Quantitation of < b > < i > Artemisia < /i > < /b > -Specific Immunoglobulin E
Conclusion: AnArtemisia-sIgE quantitation assay based on LICA was successfully established. Its performance satisfied the clinical requirements and could be widely used in clinical laboratories.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 16, 2021 Category: Allergy & Immunology Source Type: research

Mepolizumab Is an Effective Option in Severe Eosinophilic Asthma Regardless of Baseline Features: Single-Center Real-Life Data
Conclusion: Mepolizumab effectively reduced asthma exacerbations, steroid requirement, blood eosinophil counts and improved asthma control, pulmonary function, sinonasal symptoms and quality of life. Our data suggest that mepolizumab would be effective in selected patients in real-life settings.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 14, 2021 Category: Allergy & Immunology Source Type: research

Predictors of Airway Hyperresponsiveness in Symptomatic Children with Normal Spirometry and Suspicious of Possible Asthma
Conclusion: In children suspected of having asthma, but without an obstructive pattern in the spirometry, combining independent predictors, which can be easily obtained in clinical practice, might be used to identify children with AHR.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 10, 2021 Category: Allergy & Immunology Source Type: research

Food-Induced Anaphylaxis among Children Weighing & #x3c;15 kg: A Single-Center Case Series of the Pediatric Emergency Department
Conclusion: Food-induced anaphylaxis among children weighing #x3c;15 kg occurred as frequently and was as severe as that among children weighing 15 kg or more. However, the proportion of patients prescribed EAIs was very low in children weighing #x3c;15 kg with food-induced anaphylaxis. The potential need for EAIs is suggested among children weighing #x3c;15 kg, especially among children weighing 10 kg or more but #x3c;15 kg.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 9, 2021 Category: Allergy & Immunology Source Type: research

The Effect of COVID-19 Pandemic on the Infants ’ Microbiota and the Probability of Development of Allergic and Autoimmune Diseases
The human microbiota plays a significant role in various mechanisms of the body. The formation of a healthy microbiota, especially in early childhood, has a significant effect on maintaining human health. Since the onset of coronavirus disease 2019 (COVID-19), the disease has caused many changes in human life. According to the available information, many of these factors affect the composition and diversity of the body ’s microbiota, so this pandemic may alter and disrupt the microbiota and consequently increase the incidence of other diseases such as allergic and autoimmune disorders, especially in children and infants ...
Source: International Archives of Allergy and Immunology - December 3, 2021 Category: Allergy & Immunology Source Type: research

Depression, Anxiety, and Suicidal Ideation in Patients with Atopic Eczema in a Prospective Study in Leipzig, Germany
Conclusion: Patients with AE being currently under treatment in our department had significantly increased scores indicating depression and anxiety. Suicidal tendency was increased in patients with severe AE.Key Message: AE patients may develop depression, anxiety, and suicidal ideation. Patient-oriented scores may help identifying high-risk patients.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 3, 2021 Category: Allergy & Immunology Source Type: research

The Effects of the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin, Cannabinoid Agonist WIN 55,212-2, and Nitric Oxide Synthase Inhibitor N ω-Nitro-L-Arginine Methyl Ester Hydrochloride on the Serotonin and Dry Skin-Induced Itch
Conclusion: These results demonstrate that Hsp90 may play a role in the peripheral pathway of pruritus, and cannabinoid agonists and Hsp90 inhibitors can be used together in the treatment of pruritus.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 3, 2021 Category: Allergy & Immunology Source Type: research

Salidroside Attenuates Airway Inflammation and Remodeling via the miR-323-3p/SOCS5 Axis in Asthmatic Mice
Conclusion: Sal inhibited miR-323-3p expression to promote SOCS5 transcription, thereby attenuating airway inflammation and remodeling in asthmatic mice.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 2, 2021 Category: Allergy & Immunology Source Type: research

Contents Vol. 182, 2021
Int Arch Allergy Immunol 2021;182:I –X (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 2, 2021 Category: Allergy & Immunology Source Type: research

Acknowledgement to the Reviewers
Int Arch Allergy Immunol 2021;182:1255 –1256 (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 2, 2021 Category: Allergy & Immunology Source Type: research