Recurrent seizures in an adolescent female-A daunting puzzle
Mohanasundaram Subashri, ND Srinivasa Prasad, Edwin Fernando, Yashwanth T RajIndian Journal of Nephrology 2021 31(1):67-70
Acute porphyrias are metabolic disorders resulting from deficiency of a specific enzyme involved in heme biosynthetic pathway. These deficiencies also affect normal renal physiology, as kidneys are also involved in heme synthesis. Sometimes, this could even lead to end stage renal disease. Acute Intermittent Porphyria, an autosomal dominant disorder arising from half-normal activity of hydroxymethylbilane synthase, is characterized by occurrence of vague neurovisceral attacks (abdominal pain, nausea, ...
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Mohanasundaram Subashri ND Srinivasa Prasad Edwin Fernando Yashwanth T Raj Source Type: research
A Case of Hearing Impairment with Renal Dysfunction
GK Prakash, Sagar C Kulkarni, SR Rashmi, V Mahesha, S Vishwanath, HS BallalIndian Journal of Nephrology 2021 31(1):64-66
Hearing impairment in a patient with renal failure is an important clue towards etiologic diagnosis of kidney disease. Variety of hereditary diseases, developmental defects, and toxins involve these two organs. However, additional retinopathy is seen in quite a few diseases which include Alport's syndrome and Muckle–Wells syndrome (MWS). We are reporting a case of middle-aged woman with childhood-onset of hearing impairment who presented with renal failure and was diagnosed to ha...
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: GK Prakash Sagar C Kulkarni SR Rashmi V Mahesha S Vishwanath HS Ballal Source Type: research
A Case of Joubert Syndrome with Chronic Kidney Disease
MP Shamsudheen, Uttara Das, Gangadhar Taduri, Swarnalatha Guditi, Raja Karthik, Rajani ThakurIndian Journal of Nephrology 2021 31(1):61-63
Joubert syndrome is a genetically heterogeneous disorder that belongs to the group of cerebello-oculo-renal syndromes. It is characterised by neurodevelopmental abnormalities and complex midbrain-hindbrain malformation, visible on brain imaging as a molar tooth sign. It is classified as a ciliopathy and has variable renal involvement. Herein, we report a case of a 9-year-old boy with developmental delay, presented as chronic kidney disease and evaluation showed features of Joubert synd...
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: MP Shamsudheen Uttara Das Gangadhar Taduri Swarnalatha Guditi Raja Karthik Rajani Thakur Source Type: research
A rare case of APRT deficiency with end-stage renal failure and successful renal transplant
Manish Sharma, Swarnalata Gowrishankar, Tarun K JelokaIndian Journal of Nephrology 2021 31(1):57-60
Renal calculus disease is a common cause of renal injury. However, crystal nephropathy (uric acid, oxalate, and dihydroxyadenine) can present as chronic kidney disease without any evidence of renal stones. If left undiagnosed, there is a potential chance of recurrence in the allograft leading to graft failure after transplantation. Pretransplant identification and management can avoid such complications. Here, we describe a case of APRT deficiency leading to crystal nephropathy and end-stage renal failure in a patient who u...
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Manish Sharma Swarnalata Gowrishankar Tarun K Jeloka Source Type: research
Fracture Embolism of In-situ Guidewire & #8211;Bewildering Aetiology of Protracted Pyrexia in a Patient with End Stage Renal Disease!
Vivek Sood, Vivek Kumar, Manish Rathi, Navin Pattanashetty, Raja RamachandranIndian Journal of Nephrology 2021 31(1):54-56
Guidewire embolism during venous access for haemodialysis is not uncommon yet potentially avoidable iatrogenic complication. Unrecognised, long-standing in-situ guidewire may predispose to thrombosis and become a nidus for infection. This entity should always be borne in mind and considered as one of the differentials of unexplained pyrexia in patient on maintenance haemodialysis. In this context, we report a patient on maintenance dialysis who presented with fever of 6 weeks duration with no localisi...
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Vivek Sood Vivek Kumar Manish Rathi Navin Pattanashetty Raja Ramachandran Source Type: research
Immune Complex Associated Glomerulonephritis in a Patient with Prefibrotic Primary Myelofibrosis: A Case Report
Mahendra Atlani, Tanya Sharma, Deepti Joshi, Aman KumarIndian Journal of Nephrology 2021 31(1):50-53
A case of prefibrotic myelofibrosis with immune complex-mediated glomerulonephritis is presented. A 45-year-old female, with history of right subclavian and axillary vein thrombosis, presented with abdominal distension, facial puffiness, and pedal edema. Evaluation revealed deranged renal functions with nephrotic range proteinuria and acute kidney injury. JAK2 mutation evaluated in view of portal vein thrombosis and splenomegaly was positive. Renal biopsy revealed mesangial proliferative glomerulonephritis with full house ...
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Mahendra Atlani Tanya Sharma Deepti Joshi Aman Kumar Source Type: research
Does hemodialysis need to be initiated to improve platelet function in CKD G5 patients ? A pilot prospective, observational cohort study
Conclusion: HD for the sole purpose of improving platelet function is only of benefit in the subgroup of patients with an abnormal CADPCT at baseline, with close to 50% normalizing their platelet function after three sessions of low flow, short duration, counter-current HD. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Vinod B Murakonda Anjali Mohapatra Tulasi Geevar Ramya Vijayan Shailesh Kakde Shibu Jacob Suceena Alexander Vinoi G David Sukesh C Nair Santosh Varughese Anna T Valson Source Type: research
Body fat in children with chronic kidney disease - A comparative study of bio-impedance analysis with dual energy X-ray absorptiometry
Conclusion: In children with CKD, body fat is preserved in the majority. Among the two measures of fat, BF% estimated by BIA did not compare well with DXA while FMI measure was comparable with a lower bias. However, due to lack of reference values in Indian children for FMI obtained by BIA, BIA cannot be used to measure fat in this population. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Arpana Iyengar Rebecca Kuriyan Anura V Kurpad Anil Vasudevan Source Type: research
Immunoadsorption column reuse
Conclusion: IA column reuse up to two times showed efficacy in the successful reduction of antibody titers. Column reuse was not associated with any significant side effects. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Vaibhav Tiwari Anurag Gupta Smita Divyaveer Vinant Bhargava Manish Malik Ashwani Gupta Anil K Bhalla DS Rana Source Type: research
Is twice-weekly maintenance hemodialysis justified ?
Conclusion: Initiation at twice-weekly schedules for patients on maintenance hemodialysis is a viable option with increments in case of requirement, more so in patients with good urine output and residual renal function. The biochemical and hematological parameters were stable and within KDOQI guidelines and do not worsen with time. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Satish Mendonca Shweta Bhardwaj S Sreenivasan Devika Gupta Source Type: research
Etiological Spectrum and Histopathological Diagnosis of Rhabdomyolysis Associated Myoglobin Cast Nephropathy in South India
Conclusion: Clinicians should be aware of the wide spectrum of causes for rhabdomyolysis. The classical clinical and laboratory findings of rhabdomyolysis may not be present in many of the patients. The pathologist must have a high index of suspicion, and immunohistochemical stain should be used to confirm the diagnosis. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: KS Jansi Prema Anila Abraham Kurien Source Type: research
The Utility of Assessing CD68 & #43; Glomerular Macrophages in Assessing Endocapillary Hypercellularity in IgA Nephropathy
Conclusion: Glomerular CD68+ macrophage count seems to be a promising approach in assessing endocapillary hypercellularity. Further studies with emphasis on correlation with the clinical outcome are needed to validate its utility as an objective tool. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Neha Agrawal Swarnalata Gowrishankar Source Type: research
Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial
Conclusions: Bedtime administration of antihypertensives reverted non-dippers to dippers and slowed the decline in eGFR in CKD stages 3 and 4 compared to morning administration of antihypertensives. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Vaibhav Tiwari Arpita Ray Chaudhary Sanjay Dasgupta Smita Divyaveer Raju Kumar Sahu Atanu Pal Rajib Mondal Kapiljit Chakravarty Asit Kumar Mandal Dipankar Sircar Rajendra Pandey Source Type: research
Enamel renal syndrome: A systematic review
The objective is to characterize ERS by systematically literature reviewing, highlighting the main findings of the syndrome to increase knowledge about this condition in the health professionals. The study is a systematic review of the scientific literature, whose research was developed in the PubMed database in March 2018. A total of 69 articles were found. Two authors analyzed their abstracts and selected, according to the language and main subject, 30 articles to write this study. A total of 69 patients were cited in the studies and their data were analysed. There was gender equivalence and the ages ranged from 1 to 64 ...
Source: Indian Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Maria Luiza Morais Farias Gabriela Oliveira Ornela Rodrigo Soares de Andrade Daniella Reis B. Martelli Ver & #244;nica Oliveira Dias Herc & #237;lio Martelli J & #250;nior Source Type: research
Hypermanganesemia in patients with hyperintensity in basal ganglia with ongoing maintenance hemodialysis
Topoti Mukherjee, Ravi Shankar Bonu, Abha VermaIndian Journal of Nephrology 2020 30(6):440-441 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - December 4, 2020 Category: Urology & Nephrology Authors: Topoti Mukherjee Ravi Shankar Bonu Abha Verma Source Type: research
