Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis
CONCLUSIONS: This integrative analysis of muscle transcriptome and intramuscular FA profile revealed valuable information about key candidate genes and potential regulators for FA and lipid metabolism in pigs, among which some transcription factors are proposed to control gene expression and modulate FA composition differences.PMID:38347496 | PMC:PMC10860264 | DOI:10.1186/s12711-024-00882-x (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 12, 2024 Category: Genetics & Stem Cells Authors: Jes ús Valdés-Hernández Josep M Folch Daniel Crespo-Piazuelo Mag í Passols Cristina Sebasti à Lourdes Criado-Mesas Anna Castell ó Armand S ánchez Yuliaxis Ramayo-Caldas Source Type: research
Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis
CONCLUSIONS: This integrative analysis of muscle transcriptome and intramuscular FA profile revealed valuable information about key candidate genes and potential regulators for FA and lipid metabolism in pigs, among which some transcription factors are proposed to control gene expression and modulate FA composition differences.PMID:38347496 | PMC:PMC10860264 | DOI:10.1186/s12711-024-00882-x (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 12, 2024 Category: Genetics & Stem Cells Authors: Jes ús Valdés-Hernández Josep M Folch Daniel Crespo-Piazuelo Mag í Passols Cristina Sebasti à Lourdes Criado-Mesas Anna Castell ó Armand S ánchez Yuliaxis Ramayo-Caldas Source Type: research
Ancestral alleles defined for 70 million cattle variants using a population-based likelihood ratio test
CONCLUSIONS: Considering the high concordance of ancestral alleles across studies, the ancestral alleles determined in this study including those not previously listed, particularly those with high-probability estimates, may be used for further genetic analyses with reasonable accuracy. Our approach that used predetermined variants in species and the likelihood ratio test to determine ancestral alleles is applicable to other species for which sequence level genotypes are available.PMID:38321371 | PMC:PMC10848479 | DOI:10.1186/s12711-024-00879-6 (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 6, 2024 Category: Genetics & Stem Cells Authors: Jigme Dorji Antonio Reverter Pamela A Alexandre Amanda J Chamberlain Christy J Vander-Jagt James Kijas Laercio R Porto-Neto Source Type: research
Inbreeding depression is associated with recent homozygous-by-descent segments in Belgian Blue beef cattle
CONCLUSIONS: Overall, our results suggest that mutational load decreases with haplotype age, and that mating plans should consider mainly the levels of recent inbreeding.PMID:38297209 | PMC:PMC10832232 | DOI:10.1186/s12711-024-00878-7 (Source: Genet Sel Evol)
Source: Genet Sel Evol - January 31, 2024 Category: Genetics & Stem Cells Authors: Maulana Mughitz Naji Jos é Luis Gualdrón Duarte Natalia Soledad Forneris Tom Druet Source Type: research
Correction: Validation of reaction norm breeding values for robustness in Australian sheep
Genet Sel Evol. 2024 Jan 25;56(1):9. doi: 10.1186/s12711-024-00877-8.NO ABSTRACTPMID:38273358 | PMC:PMC10811839 | DOI:10.1186/s12711-024-00877-8 (Source: Genet Sel Evol)
Source: Genet Sel Evol - January 25, 2024 Category: Genetics & Stem Cells Authors: Dominic L Waters Sam A Clark Daniel J Brown Samuel F Walkom Julius H J van der Werf Source Type: research
The potential of microbiota information to better predict efficiency traits in growing pigs fed a conventional and a high-fiber diet
CONCLUSIONS: The microbiota is a relevant source of information to predict DE regardless of the diet, but not to predict growth and FE traits for which prediction accuracies were similar to those obtained with genomic information only. Further analyses on larger datasets and more diverse diets should be carried out to complement and consolidate these results.PMID:38243193 | PMC:PMC10797989 | DOI:10.1186/s12711-023-00865-4 (Source: Genet Sel Evol)
Source: Genet Sel Evol - January 19, 2024 Category: Genetics & Stem Cells Authors: Vanille D éru Francesco Tiezzi C éline Carillier-Jacquin Benoit Blanchet Laurent Cauquil Olivier Zemb Alban Bouquet Christian Maltecca H élène Gilbert Source Type: research
Simulation of dual-purpose chicken breeding programs implementing gene editing
CONCLUSIONS: This simulation demonstrates the potential of gene editing to accelerate the simultaneous improvement of negatively correlated traits. When the risk of negative consequences from gene editing persists, the number of SNPs to be edited should be chosen carefully to obtain the optimal genetic gain.PMID:38233762 | PMC:PMC10795215 | DOI:10.1186/s12711-023-00874-3 (Source: Genet Sel Evol)
Source: Genet Sel Evol - January 17, 2024 Category: Genetics & Stem Cells Authors: Edward Y S Chuang Robin Wellmann Franck L B Meijboom Jens Tetens J örn Bennewitz Source Type: research
A cautionary tale of low-pass sequencing and imputation with respect to haplotype accuracy
CONCLUSIONS: We demonstrate that saliva-derived canine DNA is suitable for whole-genome sequencing, highlighting the feasibility of client-based sampling. Low-pass sequencing and imputation require caution as incorrect allele assignments result when the subject possesses alleles that are absent in the reference panel. Larger panels have the capacity for greater allelic diversity, which should reduce the potential for imputation error. Although low-pass sequencing can accurately impute allele dosage, we highlight issues with phasing accuracy that impact haplotype-based analyses. Consequently, if accurately phased genotypes ...
Source: Genet Sel Evol - January 12, 2024 Category: Genetics & Stem Cells Authors: David Wragg Wengang Zhang Sarah Peterson Murthy Yerramilli Richard Mellanby Jeffrey J Schoenebeck Dylan N Clements Source Type: research
Advances in understanding the genetic architecture of antibody response to paratuberculosis in sheep by heritability estimate and LDLA mapping analyses and investigation of candidate regions using sequence-based data
CONCLUSIONS: Our results confirm the involvement of the host's genetics in susceptibility to MAP in sheep and suggest that selective breeding may be an option to limit the infection. The estimated heritability is moderate with a relevant portion being due to a highly significant region on ovine chromosome 20. The results of the combined use of sequence-based data and functional analyses suggest several genes belonging to the MHC II as the most likely candidates, although no mutations in their coding regions showed a significant association. Nevertheless, information from genotypes of two highly significant polymorphisms in...
Source: Genet Sel Evol - January 10, 2024 Category: Genetics & Stem Cells Authors: Mario Graziano Usai Sara Casu Tiziana Sechi Sotero L Salaris Sabrina Miari Giuliana Mulas Maria Giovanna Cancedda Ciriaco Ligios Antonello Carta Source Type: research
Validation of reaction norm breeding values for robustness in Australian sheep
CONCLUSIONS: Slope estimated breeding values (EBV) obtained using reaction norm models were predictive of the phenotypic robustness of progeny across different environments and were consistent for sires with progeny in two different datasets. Selection based on reaction norm EBV could be used to increase the robustness of a population to environmental variation.PMID:38183016 | PMC:PMC10768286 | DOI:10.1186/s12711-023-00872-5 (Source: Genet Sel Evol)
Source: Genet Sel Evol - January 5, 2024 Category: Genetics & Stem Cells Authors: Dominic L Waters Sam A Clark Daniel J Brown Samuel F Walkom Julius H J van der Werf Source Type: research
Validation of reaction norm breeding values for robustness in Australian sheep
CONCLUSIONS: Slope estimated breeding values (EBV) obtained using reaction norm models were predictive of the phenotypic robustness of progeny across different environments and were consistent for sires with progeny in two different datasets. Selection based on reaction norm EBV could be used to increase the robustness of a population to environmental variation.PMID:38183016 | PMC:PMC10768286 | DOI:10.1186/s12711-023-00872-5 (Source: Genet Sel Evol)
Source: Genet Sel Evol - January 5, 2024 Category: Genetics & Stem Cells Authors: Dominic L Waters Sam A Clark Daniel J Brown Samuel F Walkom Julius H J van der Werf Source Type: research
Validation of reaction norm breeding values for robustness in Australian sheep
CONCLUSIONS: Slope estimated breeding values (EBV) obtained using reaction norm models were predictive of the phenotypic robustness of progeny across different environments and were consistent for sires with progeny in two different datasets. Selection based on reaction norm EBV could be used to increase the robustness of a population to environmental variation.PMID:38183016 | PMC:PMC10768286 | DOI:10.1186/s12711-023-00872-5 (Source: Genet Sel Evol)
Source: Genet Sel Evol - January 5, 2024 Category: Genetics & Stem Cells Authors: Dominic L Waters Sam A Clark Daniel J Brown Samuel F Walkom Julius H J van der Werf Source Type: research
Validation of reaction norm breeding values for robustness in Australian sheep
CONCLUSIONS: Slope estimated breeding values (EBV) obtained using reaction norm models were predictive of the phenotypic robustness of progeny across different environments and were consistent for sires with progeny in two different datasets. Selection based on reaction norm EBV could be used to increase the robustness of a population to environmental variation.PMID:38183016 | DOI:10.1186/s12711-023-00872-5 (Source: Genet Sel Evol)
Source: Genet Sel Evol - January 5, 2024 Category: Genetics & Stem Cells Authors: Dominic L Waters Sam A Clark Daniel J Brown Samuel F Walkom Julius H J van der Werf Source Type: research
Phenotype transition from wild mouflon to domestic sheep
Genet Sel Evol. 2024 Jan 2;56(1):1. doi: 10.1186/s12711-023-00871-6.ABSTRACTThe domestication of animals started around 12,000 years ago in the Near East region. This "endless process" is characterized by the gradual accumulation of changes that progressively marked the genetic, phenotypic and physiological differences between wild and domesticated species. The main distinctive phenotypic characteristics are not all directly attributable to the human-mediated selection of more productive traits. In the last decades, two main hypotheses have been proposed to clarify the emergence of such a set of phenotypic traits across a ...
Source: Genet Sel Evol - January 3, 2024 Category: Genetics & Stem Cells Authors: Paolo Mereu Monica Pirastru Daria Sanna Giovanni Bassu Salvatore Naitana Giovanni Giuseppe Leoni Source Type: research
The demographic history and adaptation of Canarian goat breeds to environmental conditions through the use of genome-wide SNP data
CONCLUSIONS: This genome-wide analysis sheds new light on the evolutionary history of the four breeds that inhabit the Canary Islands. Our findings suggest a North African origin of the Canarian goats. In addition, within the genomic regions highlighted by the ROH and FST approaches, several genes related to body size and heat tolerance were identified.PMID:38172652 | PMC:PMC10763158 | DOI:10.1186/s12711-023-00869-0 (Source: Genet Sel Evol)
Source: Genet Sel Evol - January 3, 2024 Category: Genetics & Stem Cells Authors: Gabriele Senczuk Martina Macr ì Marika Di Civita Salvatore Mastrangelo Maria Del Rosario Fresno Juan Capote Fabio Pilla Juan Vicente Delgado Marcel Amills Amparo Mart ínez Source Type: research
