Mendelian randomization analysis of 34,497 German Holstein cows to infer causal associations between milk production and health traits
CONCLUSIONS: Our results confirm the known negative genetic connection between health traits and MY in dairy cattle. In addition, they provide new information about causality, which for example points to the negative energy balance mediating the connection between these traits. This knowledge helps to better understand whether the negative genetic correlation is based on pleiotropy, linkage between causal variants for both trait complexes, or indeed on a causal association.PMID:38589805 | PMC:PMC11000328 | DOI:10.1186/s12711-024-00896-5 (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 8, 2024 Category: Genetics & Stem Cells Authors: Helen Schneider Valentin Haas Ana-Marija Krizanac Clemens Falker-Gieske Johannes Heise Jens Tetens Georg Thaller J örn Bennewitz Source Type: research
Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation
CONCLUSIONS: Analysis of the signatures of selection uncovered genes that are likely related to environmental adaptation and a SNP missense mutation in the TSHR gene that affects the protein structure and stability. It also provides information on the evolution of the phylogeographic structure of Chinese indigenous sheep populations. These results provide important genetic resources for future breeding studies and new perspectives on how animals can adapt to climate change.PMID:38565986 | PMC:PMC10988870 | DOI:10.1186/s12711-024-00880-z (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Meilin Jin Huihua Wang Gang Liu Jian Lu Zehu Yuan Taotao Li Engming Liu Zengkui Lu Lixin Du Caihong Wei Source Type: research
Microbiome composition as a potential predictor of longevity in rabbits
CONCLUSIONS: Our results indicate that the first parity gut microbiome profile differs between the two rabbit maternal lines (A and LP) and, to a lesser extent, between animals of line LP with different longevities (LLP and HLP). Several genera were able to discriminate animals from the two lines and animals with different longevities, which shows that the gut microbiome could be used as a predictive factor for longevity, or as a selection criterion for these traits.PMID:38565991 | PMC:PMC10986140 | DOI:10.1186/s12711-024-00895-6 (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Iliyass Biada Noelia Ib áñez-Escriche Agust ín Blasco Cristina Casto-Rebollo Maria A Santacreu Source Type: research
Genetic introgression from commercial European pigs to the indigenous Chinese Lijiang breed and associated changes in phenotypes
CONCLUSIONS: Our study provides evidence of introgressed European haplotypes in the LJP breed and describes the potential role of EP introgression on phenotypic changes of this indigenous breed.PMID:38566006 | PMC:PMC10985947 | DOI:10.1186/s12711-024-00893-8 (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Ruifei Yang Siqi Jin Suyun Fang Dawei Yan Hao Zhang Jingru Nie Jinqiao Liu Minjuan Lv Bo Zhang Xinxing Dong Source Type: research
Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation
CONCLUSIONS: Analysis of the signatures of selection uncovered genes that are likely related to environmental adaptation and a SNP missense mutation in the TSHR gene that affects the protein structure and stability. It also provides information on the evolution of the phylogeographic structure of Chinese indigenous sheep populations. These results provide important genetic resources for future breeding studies and new perspectives on how animals can adapt to climate change.PMID:38565986 | PMC:PMC10988870 | DOI:10.1186/s12711-024-00880-z (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Meilin Jin Huihua Wang Gang Liu Jian Lu Zehu Yuan Taotao Li Engming Liu Zengkui Lu Lixin Du Caihong Wei Source Type: research
Microbiome composition as a potential predictor of longevity in rabbits
CONCLUSIONS: Our results indicate that the first parity gut microbiome profile differs between the two rabbit maternal lines (A and LP) and, to a lesser extent, between animals of line LP with different longevities (LLP and HLP). Several genera were able to discriminate animals from the two lines and animals with different longevities, which shows that the gut microbiome could be used as a predictive factor for longevity, or as a selection criterion for these traits.PMID:38565991 | PMC:PMC10986140 | DOI:10.1186/s12711-024-00895-6 (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Iliyass Biada Noelia Ib áñez-Escriche Agust ín Blasco Cristina Casto-Rebollo Maria A Santacreu Source Type: research
Genetic introgression from commercial European pigs to the indigenous Chinese Lijiang breed and associated changes in phenotypes
CONCLUSIONS: Our study provides evidence of introgressed European haplotypes in the LJP breed and describes the potential role of EP introgression on phenotypic changes of this indigenous breed.PMID:38566006 | PMC:PMC10985947 | DOI:10.1186/s12711-024-00893-8 (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Ruifei Yang Siqi Jin Suyun Fang Dawei Yan Hao Zhang Jingru Nie Jinqiao Liu Minjuan Lv Bo Zhang Xinxing Dong Source Type: research
Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation
CONCLUSIONS: Analysis of the signatures of selection uncovered genes that are likely related to environmental adaptation and a SNP missense mutation in the TSHR gene that affects the protein structure and stability. It also provides information on the evolution of the phylogeographic structure of Chinese indigenous sheep populations. These results provide important genetic resources for future breeding studies and new perspectives on how animals can adapt to climate change.PMID:38565986 | PMC:PMC10988870 | DOI:10.1186/s12711-024-00880-z (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Meilin Jin Huihua Wang Gang Liu Jian Lu Zehu Yuan Taotao Li Engming Liu Zengkui Lu Lixin Du Caihong Wei Source Type: research
Microbiome composition as a potential predictor of longevity in rabbits
CONCLUSIONS: Our results indicate that the first parity gut microbiome profile differs between the two rabbit maternal lines (A and LP) and, to a lesser extent, between animals of line LP with different longevities (LLP and HLP). Several genera were able to discriminate animals from the two lines and animals with different longevities, which shows that the gut microbiome could be used as a predictive factor for longevity, or as a selection criterion for these traits.PMID:38565991 | PMC:PMC10986140 | DOI:10.1186/s12711-024-00895-6 (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Iliyass Biada Noelia Ib áñez-Escriche Agust ín Blasco Cristina Casto-Rebollo Maria A Santacreu Source Type: research
Genetic introgression from commercial European pigs to the indigenous Chinese Lijiang breed and associated changes in phenotypes
CONCLUSIONS: Our study provides evidence of introgressed European haplotypes in the LJP breed and describes the potential role of EP introgression on phenotypic changes of this indigenous breed.PMID:38566006 | PMC:PMC10985947 | DOI:10.1186/s12711-024-00893-8 (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Ruifei Yang Siqi Jin Suyun Fang Dawei Yan Hao Zhang Jingru Nie Jinqiao Liu Minjuan Lv Bo Zhang Xinxing Dong Source Type: research
Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation
CONCLUSIONS: Analysis of the signatures of selection uncovered genes that are likely related to environmental adaptation and a SNP missense mutation in the TSHR gene that affects the protein structure and stability. It also provides information on the evolution of the phylogeographic structure of Chinese indigenous sheep populations. These results provide important genetic resources for future breeding studies and new perspectives on how animals can adapt to climate change.PMID:38565986 | PMC:PMC10988870 | DOI:10.1186/s12711-024-00880-z (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Meilin Jin Huihua Wang Gang Liu Jian Lu Zehu Yuan Taotao Li Engming Liu Zengkui Lu Lixin Du Caihong Wei Source Type: research
Microbiome composition as a potential predictor of longevity in rabbits
CONCLUSIONS: Our results indicate that the first parity gut microbiome profile differs between the two rabbit maternal lines (A and LP) and, to a lesser extent, between animals of line LP with different longevities (LLP and HLP). Several genera were able to discriminate animals from the two lines and animals with different longevities, which shows that the gut microbiome could be used as a predictive factor for longevity, or as a selection criterion for these traits.PMID:38565991 | PMC:PMC10986140 | DOI:10.1186/s12711-024-00895-6 (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Iliyass Biada Noelia Ib áñez-Escriche Agust ín Blasco Cristina Casto-Rebollo Maria A Santacreu Source Type: research
Genetic introgression from commercial European pigs to the indigenous Chinese Lijiang breed and associated changes in phenotypes
CONCLUSIONS: Our study provides evidence of introgressed European haplotypes in the LJP breed and describes the potential role of EP introgression on phenotypic changes of this indigenous breed.PMID:38566006 | PMC:PMC10985947 | DOI:10.1186/s12711-024-00893-8 (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Ruifei Yang Siqi Jin Suyun Fang Dawei Yan Hao Zhang Jingru Nie Jinqiao Liu Minjuan Lv Bo Zhang Xinxing Dong Source Type: research
Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation
CONCLUSIONS: Analysis of the signatures of selection uncovered genes that are likely related to environmental adaptation and a SNP missense mutation in the TSHR gene that affects the protein structure and stability. It also provides information on the evolution of the phylogeographic structure of Chinese indigenous sheep populations. These results provide important genetic resources for future breeding studies and new perspectives on how animals can adapt to climate change.PMID:38565986 | DOI:10.1186/s12711-024-00880-z (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Meilin Jin Huihua Wang Gang Liu Jian Lu Zehu Yuan Taotao Li Engming Liu Zengkui Lu Lixin Du Caihong Wei Source Type: research
Microbiome composition as a potential predictor of longevity in rabbits
CONCLUSIONS: Our results indicate that the first parity gut microbiome profile differs between the two rabbit maternal lines (A and LP) and, to a lesser extent, between animals of line LP with different longevities (LLP and HLP). Several genera were able to discriminate animals from the two lines and animals with different longevities, which shows that the gut microbiome could be used as a predictive factor for longevity, or as a selection criterion for these traits.PMID:38565991 | DOI:10.1186/s12711-024-00895-6 (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 2, 2024 Category: Genetics & Stem Cells Authors: Iliyass Biada Noelia Ib áñez-Escriche Agust ín Blasco Cristina Casto-Rebollo Maria A Santacreu Source Type: research
