Approaching autozygosity in a small pedigree of Gochu Asturcelta pigs
CONCLUSIONS: Parameters characterizing homozygosity may not accurately depict losses of variability in small populations in which breeding policy prohibits matings between close relatives. After BP adjustment, the performance of FROH and FHRR was highly consistent. Assuming that an increase in homozygosity depends only on pedigree depth can lead to underestimating it in populations with shallow pedigrees. An increase in pairwise homozygosity computed from either FROH or FHRR is a promising approach for characterizing autozygosity.PMID:37880572 | PMC:PMC10601182 | DOI:10.1186/s12711-023-00846-7 (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 25, 2023 Category: Genetics & Stem Cells Authors: Katherine D Arias Juan Pablo Guti érrez Iv án Fernández Isabel Álvarez F élix Goyache Source Type: research
Combined single-step evaluation of functional longevity of dairy cows including correlated traits
CONCLUSIONS: A CSS evaluation is an efficient tool to improve FL. It allows a proper combination of information on functional traits that influence culling. In contrast, because of the strong selection intensity on young bulls for functional traits, the benefit of such a "combined" evaluation of functional traits is more modest for these males.PMID:37880580 | PMC:PMC10601146 | DOI:10.1186/s12711-023-00839-6 (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 25, 2023 Category: Genetics & Stem Cells Authors: Laure-H élène Maugan Roberta Rostellato Thierry Tribout Sophie Mattalia Vincent Ducrocq Source Type: research
Approaching autozygosity in a small pedigree of Gochu Asturcelta pigs
CONCLUSIONS: Parameters characterizing homozygosity may not accurately depict losses of variability in small populations in which breeding policy prohibits matings between close relatives. After BP adjustment, the performance of FROH and FHRR was highly consistent. Assuming that an increase in homozygosity depends only on pedigree depth can lead to underestimating it in populations with shallow pedigrees. An increase in pairwise homozygosity computed from either FROH or FHRR is a promising approach for characterizing autozygosity.PMID:37880572 | DOI:10.1186/s12711-023-00846-7 (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 25, 2023 Category: Genetics & Stem Cells Authors: Katherine D Arias Juan Pablo Guti érrez Iv án Fernández Isabel Álvarez F élix Goyache Source Type: research
Combined single-step evaluation of functional longevity of dairy cows including correlated traits
CONCLUSIONS: A CSS evaluation is an efficient tool to improve FL. It allows a proper combination of information on functional traits that influence culling. In contrast, because of the strong selection intensity on young bulls for functional traits, the benefit of such a "combined" evaluation of functional traits is more modest for these males.PMID:37880580 | DOI:10.1186/s12711-023-00839-6 (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 25, 2023 Category: Genetics & Stem Cells Authors: Laure-H élène Maugan Roberta Rostellato Thierry Tribout Sophie Mattalia Vincent Ducrocq Source Type: research
Comparative analyses of dynamic transcriptome profiles highlight key response genes and dominant isoforms for muscle development and growth in chicken
CONCLUSIONS: For the first time, we identified several key genes and dominant isoforms that may be responsible for differences in muscle mass between slow-growing indigenous chicken and fast-growing commercial broiler. These findings provide new insights into the regulatory mechanisms underlying breast muscle development in chicken.PMID:37872550 | DOI:10.1186/s12711-023-00849-4 (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 23, 2023 Category: Genetics & Stem Cells Authors: Zhang Wang Weihua Tian Dandan Wang Yulong Guo Zhimin Cheng Yanyan Zhang Xinyan Li Yihao Zhi Donghua Li Zhuanjian Li Ruirui Jiang Guoxi Li Yadong Tian Xiangtao Kang Hong Li Ian C Dunn Xiaojun Liu Source Type: research
Comparative analyses of dynamic transcriptome profiles highlight key response genes and dominant isoforms for muscle development and growth in chicken
CONCLUSIONS: For the first time, we identified several key genes and dominant isoforms that may be responsible for differences in muscle mass between slow-growing indigenous chicken and fast-growing commercial broiler. These findings provide new insights into the regulatory mechanisms underlying breast muscle development in chicken.PMID:37872550 | DOI:10.1186/s12711-023-00849-4 (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 23, 2023 Category: Genetics & Stem Cells Authors: Zhang Wang Weihua Tian Dandan Wang Yulong Guo Zhimin Cheng Yanyan Zhang Xinyan Li Yihao Zhi Donghua Li Zhuanjian Li Ruirui Jiang Guoxi Li Yadong Tian Xiangtao Kang Hong Li Ian C Dunn Xiaojun Liu Source Type: research
Genomic prediction based on selective linkage disequilibrium pruning of low-coverage whole-genome sequence variants in a pure Duroc population
CONCLUSIONS: The SLDP marker selection method can be incorporated into mainstream prediction models to yield accuracy improvements for traits with a relatively simple genetic architecture, however, it has no significant advantage for traits not controlled by major QTL. The main factors that affect its performance are the genetic architecture of traits and the reliability of GWAS prior information. Our findings can facilitate the application of WGS-based genomic selection.PMID:37853325 | PMC:PMC10583454 | DOI:10.1186/s12711-023-00843-w (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 18, 2023 Category: Genetics & Stem Cells Authors: Di Zhu Yiqiang Zhao Ran Zhang Hanyu Wu Gengyuan Cai Zhenfang Wu Yuzhe Wang Xiaoxiang Hu Source Type: research
Genomic prediction based on selective linkage disequilibrium pruning of low-coverage whole-genome sequence variants in a pure Duroc population
CONCLUSIONS: The SLDP marker selection method can be incorporated into mainstream prediction models to yield accuracy improvements for traits with a relatively simple genetic architecture, however, it has no significant advantage for traits not controlled by major QTL. The main factors that affect its performance are the genetic architecture of traits and the reliability of GWAS prior information. Our findings can facilitate the application of WGS-based genomic selection.PMID:37853325 | PMC:PMC10583454 | DOI:10.1186/s12711-023-00843-w (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 18, 2023 Category: Genetics & Stem Cells Authors: Di Zhu Yiqiang Zhao Ran Zhang Hanyu Wu Gengyuan Cai Zhenfang Wu Yuzhe Wang Xiaoxiang Hu Source Type: research
Genomic prediction based on selective linkage disequilibrium pruning of low-coverage whole-genome sequence variants in a pure Duroc population
CONCLUSIONS: The SLDP marker selection method can be incorporated into mainstream prediction models to yield accuracy improvements for traits with a relatively simple genetic architecture, however, it has no significant advantage for traits not controlled by major QTL. The main factors that affect its performance are the genetic architecture of traits and the reliability of GWAS prior information. Our findings can facilitate the application of WGS-based genomic selection.PMID:37853325 | PMC:PMC10583454 | DOI:10.1186/s12711-023-00843-w (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 18, 2023 Category: Genetics & Stem Cells Authors: Di Zhu Yiqiang Zhao Ran Zhang Hanyu Wu Gengyuan Cai Zhenfang Wu Yuzhe Wang Xiaoxiang Hu Source Type: research
Genomic prediction based on selective linkage disequilibrium pruning of low-coverage whole-genome sequence variants in a pure Duroc population
CONCLUSIONS: The SLDP marker selection method can be incorporated into mainstream prediction models to yield accuracy improvements for traits with a relatively simple genetic architecture, however, it has no significant advantage for traits not controlled by major QTL. The main factors that affect its performance are the genetic architecture of traits and the reliability of GWAS prior information. Our findings can facilitate the application of WGS-based genomic selection.PMID:37853325 | DOI:10.1186/s12711-023-00843-w (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 18, 2023 Category: Genetics & Stem Cells Authors: Di Zhu Yiqiang Zhao Ran Zhang Hanyu Wu Gengyuan Cai Zhenfang Wu Yuzhe Wang Xiaoxiang Hu Source Type: research
Genomic prediction based on selective linkage disequilibrium pruning of low-coverage whole-genome sequence variants in a pure Duroc population
CONCLUSIONS: The SLDP marker selection method can be incorporated into mainstream prediction models to yield accuracy improvements for traits with a relatively simple genetic architecture, however, it has no significant advantage for traits not controlled by major QTL. The main factors that affect its performance are the genetic architecture of traits and the reliability of GWAS prior information. Our findings can facilitate the application of WGS-based genomic selection.PMID:37853325 | DOI:10.1186/s12711-023-00843-w (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 18, 2023 Category: Genetics & Stem Cells Authors: Di Zhu Yiqiang Zhao Ran Zhang Hanyu Wu Gengyuan Cai Zhenfang Wu Yuzhe Wang Xiaoxiang Hu Source Type: research
Multi-breed genomic evaluation for tropical beef cattle when no pedigree information is available
CONCLUSIONS: When no pedigree is available, breed composition and heterosis for inclusion in multi-breed genomic evaluation can be estimated from genotypes. When GEBV were predicted for herds with no data in the reference population, BayesR resulted in the highest accuracy.PMID:37845626 | PMC:PMC10578004 | DOI:10.1186/s12711-023-00847-6 (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 16, 2023 Category: Genetics & Stem Cells Authors: Ben J Hayes James Copley Elsie Dodd Elizabeth M Ross Shannon Speight Geoffry Fordyce Source Type: research
Multi-breed genomic evaluation for tropical beef cattle when no pedigree information is available
CONCLUSIONS: When no pedigree is available, breed composition and heterosis for inclusion in multi-breed genomic evaluation can be estimated from genotypes. When GEBV were predicted for herds with no data in the reference population, BayesR resulted in the highest accuracy.PMID:37845626 | DOI:10.1186/s12711-023-00847-6 (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 16, 2023 Category: Genetics & Stem Cells Authors: Ben J Hayes James Copley Elsie Dodd Elizabeth M Ross Shannon Speight Geoffry Fordyce Source Type: research
Sequence-based GWAS meta-analyses for beef production traits
CONCLUSIONS: By identifying candidate genes and potential causal variants associated with beef production traits in cattle, MA demonstrates great potential for investigating the biological mechanisms underlying these traits. As a complement to within-population GWAS, this approach can provide deeper insights into the genetic architecture of complex traits in beef cattle.PMID:37828440 | PMC:PMC10568825 | DOI:10.1186/s12711-023-00848-5 (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 12, 2023 Category: Genetics & Stem Cells Authors: Marie-Pierre Sanchez Thierry Tribout Naveen K Kadri Praveen K Chitneedi Steffen Maak Chris Hoz é Mekki Boussaha Pascal Croiseau Romain Philippe Mirjam Spengeler Christa K ühn Yining Wang Changxi Li Graham Plastow Hubert Pausch Didier Boichard Source Type: research
Sequence-based GWAS meta-analyses for beef production traits
CONCLUSIONS: By identifying candidate genes and potential causal variants associated with beef production traits in cattle, MA demonstrates great potential for investigating the biological mechanisms underlying these traits. As a complement to within-population GWAS, this approach can provide deeper insights into the genetic architecture of complex traits in beef cattle.PMID:37828440 | PMC:PMC10568825 | DOI:10.1186/s12711-023-00848-5 (Source: Genet Sel Evol)
Source: Genet Sel Evol - October 12, 2023 Category: Genetics & Stem Cells Authors: Marie-Pierre Sanchez Thierry Tribout Naveen K Kadri Praveen K Chitneedi Steffen Maak Chris Hoz é Mekki Boussaha Pascal Croiseau Romain Philippe Mirjam Spengeler Christa K ühn Yining Wang Changxi Li Graham Plastow Hubert Pausch Didier Boichard Source Type: research
