Searching for homozygous haplotype deficiency in Manech T ête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability
CONCLUSIONS: We identified five homozygous deficient haplotypes that are likely to harbor five independent deleterious recessive variants in sheep. One of these was detected in the MMUT gene, which is associated with lamb lethality in the homozygous state. A specific management of these haplotypes/variants in the MTR dairy sheep selection program would help enhance the overall fertility and lamb survival.PMID:38424485 | PMC:PMC10905913 | DOI:10.1186/s12711-024-00886-7 (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 29, 2024 Category: Genetics & Stem Cells Authors: Maxime Ben Braiek Carole Moreno-Romieux C éline André Jean-Michel Astruc Philippe Bardou Arnaud Bordes Fr édéric Debat Francis Fidelle Itsasne Granado-Tajada Chris Hoz é Florence Plisson-Petit Fran çois Rivemale Julien Sarry N émuel Tadi Florent Wo Source Type: research
Expected values for the accuracy of predicted breeding values accounting for genetic differences between reference and target populations
CONCLUSIONS: We defined an index of genetic correlation between reference and target populations, which summarizes the expected overall erosion due to differences in allele frequencies and LD patterns between populations. We used this correlation along with a trait's heritability to derive expected values for the accuracy ( R ) of PBV accounting for the erosion, and demonstrated that our derived E R | erosion is a reliable metric.PMID:38424504 | DOI:10.1186/s12711-024-00876-9 (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 29, 2024 Category: Genetics & Stem Cells Authors: Beatriz C D Cuyabano Didier Boichard Cedric Gondro Source Type: research
Searching for homozygous haplotype deficiency in Manech T ête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability
CONCLUSIONS: We identified five homozygous deficient haplotypes that are likely to harbor five independent deleterious recessive variants in sheep. One of these was detected in the MMUT gene, which is associated with lamb lethality in the homozygous state. A specific management of these haplotypes/variants in the MTR dairy sheep selection program would help enhance the overall fertility and lamb survival.PMID:38424485 | DOI:10.1186/s12711-024-00886-7 (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 29, 2024 Category: Genetics & Stem Cells Authors: Maxime Ben Braiek Carole Moreno-Romieux C éline André Jean-Michel Astruc Philippe Bardou Arnaud Bordes Fr édéric Debat Francis Fidelle Itsasne Granado-Tajada Chris Hoz é Florence Plisson-Petit Fran çois Rivemale Julien Sarry N émuel Tadi Florent Wo Source Type: research
Expected values for the accuracy of predicted breeding values accounting for genetic differences between reference and target populations
CONCLUSIONS: We defined an index of genetic correlation between reference and target populations, which summarizes the expected overall erosion due to differences in allele frequencies and LD patterns between populations. We used this correlation along with a trait's heritability to derive expected values for the accuracy ( R ) of PBV accounting for the erosion, and demonstrated that our derived E R | erosion is a reliable metric.PMID:38424504 | DOI:10.1186/s12711-024-00876-9 (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 29, 2024 Category: Genetics & Stem Cells Authors: Beatriz C D Cuyabano Didier Boichard Cedric Gondro Source Type: research
Correction: Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis
Genet Sel Evol. 2024 Feb 26;56(1):14. doi: 10.1186/s12711-024-00885-8.NO ABSTRACTPMID:38408927 | PMC:PMC10895761 | DOI:10.1186/s12711-024-00885-8 (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 26, 2024 Category: Genetics & Stem Cells Authors: Jes ús Valdés-Hernández Josep M Folch Daniel Crespo-Piazuelo Mag í Passols Cristina Sebasti à Lourdes Criado-Mesas Anna Castell ó Armand S ánchez Yuliaxis Ramayo-Caldas Source Type: research
Correction: Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis
Genet Sel Evol. 2024 Feb 26;56(1):14. doi: 10.1186/s12711-024-00885-8.NO ABSTRACTPMID:38408927 | PMC:PMC10895761 | DOI:10.1186/s12711-024-00885-8 (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 26, 2024 Category: Genetics & Stem Cells Authors: Jes ús Valdés-Hernández Josep M Folch Daniel Crespo-Piazuelo Mag í Passols Cristina Sebasti à Lourdes Criado-Mesas Anna Castell ó Armand S ánchez Yuliaxis Ramayo-Caldas Source Type: research
Correction: Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis
Genet Sel Evol. 2024 Feb 26;56(1):14. doi: 10.1186/s12711-024-00885-8.NO ABSTRACTPMID:38408927 | DOI:10.1186/s12711-024-00885-8 (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 26, 2024 Category: Genetics & Stem Cells Authors: Jes ús Valdés-Hernández Josep M Folch Daniel Crespo-Piazuelo Mag í Passols Cristina Sebasti à Lourdes Criado-Mesas Anna Castell ó Armand S ánchez Yuliaxis Ramayo-Caldas Source Type: research
Genome-wide detection of positive and balancing signatures of selection shared by four domesticated rainbow trout populations (Oncorhynchus mykiss)
CONCLUSIONS: Using material from disconnected populations of different origins allowed us to draw a genome-wide map of signatures of positive selection that are shared between these rainbow trout populations, and to identify several regions that are putatively under balancing selection. These results provide a valuable resource for future investigations of the dynamics of genetic diversity and genome evolution during domestication.PMID:38389056 | PMC:PMC10882880 | DOI:10.1186/s12711-024-00884-9 (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 23, 2024 Category: Genetics & Stem Cells Authors: Katy Paul Gwendal Restoux Florence Phocas Source Type: research
Genome-wide detection of positive and balancing signatures of selection shared by four domesticated rainbow trout populations (Oncorhynchus mykiss)
CONCLUSIONS: Using material from disconnected populations of different origins allowed us to draw a genome-wide map of signatures of positive selection that are shared between these rainbow trout populations, and to identify several regions that are putatively under balancing selection. These results provide a valuable resource for future investigations of the dynamics of genetic diversity and genome evolution during domestication.PMID:38389056 | PMC:PMC10882880 | DOI:10.1186/s12711-024-00884-9 (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 23, 2024 Category: Genetics & Stem Cells Authors: Katy Paul Gwendal Restoux Florence Phocas Source Type: research
Genome-wide detection of positive and balancing signatures of selection shared by four domesticated rainbow trout populations (Oncorhynchus mykiss)
CONCLUSIONS: Using material from disconnected populations of different origins allowed us to draw a genome-wide map of signatures of positive selection that are shared between these rainbow trout populations, and to identify several regions that are putatively under balancing selection. These results provide a valuable resource for future investigations of the dynamics of genetic diversity and genome evolution during domestication.PMID:38389056 | DOI:10.1186/s12711-024-00884-9 (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 23, 2024 Category: Genetics & Stem Cells Authors: Katy Paul Gwendal Restoux Florence Phocas Source Type: research
Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis
CONCLUSIONS: This integrative analysis of muscle transcriptome and intramuscular FA profile revealed valuable information about key candidate genes and potential regulators for FA and lipid metabolism in pigs, among which some transcription factors are proposed to control gene expression and modulate FA composition differences.PMID:38347496 | PMC:PMC10860264 | DOI:10.1186/s12711-024-00882-x (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 12, 2024 Category: Genetics & Stem Cells Authors: Jes ús Valdés-Hernández Josep M Folch Daniel Crespo-Piazuelo Mag í Passols Cristina Sebasti à Lourdes Criado-Mesas Anna Castell ó Armand S ánchez Yuliaxis Ramayo-Caldas Source Type: research
Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis
CONCLUSIONS: This integrative analysis of muscle transcriptome and intramuscular FA profile revealed valuable information about key candidate genes and potential regulators for FA and lipid metabolism in pigs, among which some transcription factors are proposed to control gene expression and modulate FA composition differences.PMID:38347496 | PMC:PMC10860264 | DOI:10.1186/s12711-024-00882-x (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 12, 2024 Category: Genetics & Stem Cells Authors: Jes ús Valdés-Hernández Josep M Folch Daniel Crespo-Piazuelo Mag í Passols Cristina Sebasti à Lourdes Criado-Mesas Anna Castell ó Armand S ánchez Yuliaxis Ramayo-Caldas Source Type: research
Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis
CONCLUSIONS: This integrative analysis of muscle transcriptome and intramuscular FA profile revealed valuable information about key candidate genes and potential regulators for FA and lipid metabolism in pigs, among which some transcription factors are proposed to control gene expression and modulate FA composition differences.PMID:38347496 | PMC:PMC10860264 | DOI:10.1186/s12711-024-00882-x (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 12, 2024 Category: Genetics & Stem Cells Authors: Jes ús Valdés-Hernández Josep M Folch Daniel Crespo-Piazuelo Mag í Passols Cristina Sebasti à Lourdes Criado-Mesas Anna Castell ó Armand S ánchez Yuliaxis Ramayo-Caldas Source Type: research
Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis
CONCLUSIONS: This integrative analysis of muscle transcriptome and intramuscular FA profile revealed valuable information about key candidate genes and potential regulators for FA and lipid metabolism in pigs, among which some transcription factors are proposed to control gene expression and modulate FA composition differences.PMID:38347496 | PMC:PMC10860264 | DOI:10.1186/s12711-024-00882-x (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 12, 2024 Category: Genetics & Stem Cells Authors: Jes ús Valdés-Hernández Josep M Folch Daniel Crespo-Piazuelo Mag í Passols Cristina Sebasti à Lourdes Criado-Mesas Anna Castell ó Armand S ánchez Yuliaxis Ramayo-Caldas Source Type: research
Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis
CONCLUSIONS: This integrative analysis of muscle transcriptome and intramuscular FA profile revealed valuable information about key candidate genes and potential regulators for FA and lipid metabolism in pigs, among which some transcription factors are proposed to control gene expression and modulate FA composition differences.PMID:38347496 | PMC:PMC10860264 | DOI:10.1186/s12711-024-00882-x (Source: Genet Sel Evol)
Source: Genet Sel Evol - February 12, 2024 Category: Genetics & Stem Cells Authors: Jes ús Valdés-Hernández Josep M Folch Daniel Crespo-Piazuelo Mag í Passols Cristina Sebasti à Lourdes Criado-Mesas Anna Castell ó Armand S ánchez Yuliaxis Ramayo-Caldas Source Type: research
