Searching for homozygous haplotype deficiency in Manech T ête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability

CONCLUSIONS: We identified five homozygous deficient haplotypes that are likely to harbor five independent deleterious recessive variants in sheep. One of these was detected in the MMUT gene, which is associated with lamb lethality in the homozygous state. A specific management of these haplotypes/variants in the MTR dairy sheep selection program would help enhance the overall fertility and lamb survival.PMID:38424485 | PMC:PMC10905913 | DOI:10.1186/s12711-024-00886-7

Source: Genet Sel Evol - February 29, 2024 Category: Genetics & Stem Cells Authors: Maxime Ben Braiek Carole Moreno-Romieux C éline André Jean-Michel Astruc Philippe Bardou Arnaud Bordes Fr édéric Debat Francis Fidelle Itsasne Granado-Tajada Chris Hoz é Florence Plisson-Petit Fran çois Rivemale Julien Sarry N émuel Tadi Florent Wo Source Type: research